SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		4 / 6 CYH A 132
THR A 133
CYH A 151
GLY A 156
 FES  A 204 (-2.3A)
None
FES  A 204 (-2.4A)
FES  A 204 (-3.9A)
 1.37A 3w9tE-3fouA:
1.7		 3w9tE-3fouA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		4 / 7 GLY A  55
ASP A  56
GLY A 191
GLU A 192
 None
 0.85A 4koeA-3fouA:
undetectable
4koeB-3fouA:
undetectable
4koeD-3fouA:
undetectable		 4koeA-3fouA:
15.23
4koeB-3fouA:
15.23
4koeD-3fouA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		5 / 10 VAL A 126
ALA A 121
GLY A  78
PHE A 108
GLY A 124
 None
 1.36A 4mmdA-3fouA:
undetectable		 4mmdA-3fouA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		5 / 9 VAL A 126
ALA A 121
GLY A  78
PHE A 108
GLY A 124
 None
 1.39A 4mmfB-3fouA:
undetectable		 4mmfB-3fouA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		4 / 7 GLY A  55
ASP A  56
GLY A 191
GLU A 192
 None
 0.91A 4z53A-3fouA:
undetectable
4z53B-3fouA:
undetectable		 4z53A-3fouA:
13.97
4z53B-3fouA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		4 / 5 VAL A 188
ASP A  56
PRO A  89
ALA A 189
 None
 1.10A 5otrA-3fouA:
undetectable		 5otrA-3fouA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT
(Thermus
thermophilus) 		5 / 12 LEU A 178
ALA A 189
ASN A 101
ALA A  84
ALA A 127
 None
 1.21A 5xiwD-3fouA:
undetectable		 5xiwD-3fouA:
21.85