SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JOL_B_FFOB361_0 (DIHYDROFOLATE REDUCTASE)	3fp9	PROTEASOME-ASSOCIATE D ATPASE (Mycobacterium tuberculosis)	5 / 12	ILE A 193 ASP A 170 LEU A 168 LEU A 164 PRO A 216	None	1.09A	1jolB-3fp9A: undetectable	1jolB-3fp9A: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCN_B_CHDB2_0 (FERROCHELATASE, MITOCHONDRIAL)	3fp9	PROTEASOME-ASSOCIATE D ATPASE (Mycobacterium tuberculosis)	3 / 3	LEU A 188 LEU A 192 ARG A 212	None	0.61A	3hcnB-3fp9A: undetectable	3hcnB-3fp9A: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2D_F_LFXF102_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	3fp9	PROTEASOME-ASSOCIATE D ATPASE (Mycobacterium tuberculosis)	3 / 4	ARG A 184 GLY A 178 GLU A 160	None	0.68A	4z2dB-3fp9A: undetectable 4z2dC-3fp9A: undetectable	4z2dB-3fp9A: 15.60 4z2dC-3fp9A: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HNX_B_TA1B902_1 (TUBULIN BETA-2B CHAIN)	3fp9	PROTEASOME-ASSOCIATE D ATPASE (Mycobacterium tuberculosis)	5 / 12	VAL A 222 ASP A 223 GLU A 160 LEU A 175 SER A 162	None	1.40A	5hnxB-3fp9A: undetectable	5hnxB-3fp9A: 14.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JOL_B_FFOB361_0","DIHYDROFOLATE REDUCTASE","3fp9","PROTEASOME-ASSOCIATED ATPASE","Mycobacterium tuberculosis",5,"ILE A 193;ASP A 170;LEU A 168;LEU A 164;PRO A 216","None","1.09A","1jolB-3fp9A:undetectable","1jolB-3fp9A:24.18"],["3HCN_B_CHDB2_0","FERROCHELATASE, MITOCHONDRIAL","3fp9","PROTEASOME-ASSOCIATED ATPASE","Mycobacterium tuberculosis",3,"LEU A 188;LEU A 192;ARG A 212","None","0.61A","3hcnB-3fp9A:undetectable","3hcnB-3fp9A:18.39"],["4Z2D_F_LFXF102_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","3fp9","PROTEASOME-ASSOCIATED ATPASE","Mycobacterium tuberculosis",3,"ARG A 184;GLY A 178;GLU A 160","None","0.68A","4z2dB-3fp9A:undetectable;4z2dC-3fp9A:undetectable","4z2dB-3fp9A:15.60;4z2dC-3fp9A:21.11"],["5HNX_B_TA1B902_1","TUBULIN BETA-2B CHAIN","3fp9","PROTEASOME-ASSOCIATED ATPASE","Mycobacterium tuberculosis",5,"VAL A 222;ASP A 223;GLU A 160;LEU A 175;SER A 162","None","1.40A","5hnxB-3fp9A:undetectable","5hnxB-3fp9A:14.71"]]