SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 11 ILE A 241
ALA A 162
ILE A 256
ILE A 227
ILE A 173
 None
 1.05A 1dyrA-3fpcA:
undetectable		 1dyrA-3fpcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 9 LEU A 189
ILE A 164
ARG A 301
VAL A 240
GLY A 263
 None
 1.23A 1e7aB-3fpcA:
undetectable		 1e7aB-3fpcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 ASP A  89
ASP A 128
LYS A 111
 None
 1.09A 1lqtB-3fpcA:
3.8		 1lqtB-3fpcA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 ASP A  89
ASP A 128
LYS A 111
 None
 1.12A 1lquB-3fpcA:
undetectable		 1lquB-3fpcA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 11 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.89A 1ohrA-3fpcA:
undetectable		 1ohrA-3fpcA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
 0.77A 1q23C-3fpcA:
undetectable		 1q23C-3fpcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
 0.75A 1q23H-3fpcA:
undetectable		 1q23H-3fpcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
 0.75A 1q23J-3fpcA:
undetectable		 1q23J-3fpcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 ILE A 216
ILE A 256
VAL A 236
ILE A 173
ILE A 262
 None
 1.25A 1r5lA-3fpcA:
undetectable		 1r5lA-3fpcA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 0.99A 1sdtB-3fpcA:
undetectable		 1sdtB-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 10 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.90A 1t3rA-3fpcA:
undetectable		 1t3rA-3fpcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.69A 1wmqA-3fpcA:
undetectable		 1wmqA-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.70A 1wmqB-3fpcA:
undetectable		 1wmqB-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.70A 1wpuA-3fpcA:
undetectable		 1wpuA-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.69A 1wpuB-3fpcA:
undetectable		 1wpuB-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.66A 1wrqA-3fpcA:
undetectable		 1wrqA-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.66A 1wrqB-3fpcA:
undetectable		 1wrqB-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.83A 2bpxB-3fpcA:
undetectable		 2bpxB-3fpcA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		6 / 12 GLY A 155
ASN A 264
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.18A 2q64B-3fpcA:
undetectable		 2q64B-3fpcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
ASN A 264
GLY A 174
ILE A 175
VAL A 170
 None
 0.95A 2qakB-3fpcA:
undetectable		 2qakB-3fpcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 9 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.82A 2qmmA-3fpcA:
undetectable		 2qmmA-3fpcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 11 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.84A 2qmmA-3fpcA:
undetectable
2qmmB-3fpcA:
undetectable		 2qmmA-3fpcA:
20.65
2qmmB-3fpcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.86A 2r5pB-3fpcA:
undetectable		 2r5pB-3fpcA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.87A 2r5pD-3fpcA:
undetectable		 2r5pD-3fpcA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 11 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.88A 2r5qB-3fpcA:
undetectable		 2r5qB-3fpcA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 ILE A  49
THR A  43
LEU A 107
VAL A 115
ILE A  86
 None
 1.18A 2vn0A-3fpcA:
undetectable		 2vn0A-3fpcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 7 VAL A 178
ASN A 264
GLY A 263
VAL A 172
ASP A 261
 None
 1.41A 2y05A-3fpcA:
25.2
2y05B-3fpcA:
25.2		 2y05A-3fpcA:
26.81
2y05B-3fpcA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.88A 3bvbB-3fpcA:
undetectable		 3bvbB-3fpcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.84A 3d1xA-3fpcA:
undetectable		 3d1xA-3fpcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.82A 3d1yA-3fpcA:
undetectable		 3d1yA-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.01A 3d1zA-3fpcA:
undetectable		 3d1zA-3fpcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.86A 3k4vA-3fpcA:
undetectable		 3k4vA-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.86A 3k4vB-3fpcA:
undetectable		 3k4vB-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 10 GLY A 155
ASN A 264
GLY A 174
ILE A 175
VAL A 170
 None
 0.88A 3lzvA-3fpcA:
undetectable		 3lzvA-3fpcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 4 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.38A 3n65A-3fpcA:
0.0		 3n65A-3fpcA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.85A 3ndtA-3fpcA:
undetectable		 3ndtA-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.85A 3ndtB-3fpcA:
undetectable		 3ndtB-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.81A 3ndtD-3fpcA:
undetectable		 3ndtD-3fpcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 9 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.88A 3oxvA-3fpcA:
undetectable		 3oxvA-3fpcA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 10 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.92A 3oxwA-3fpcA:
undetectable		 3oxwA-3fpcA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 10 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.94A 3oy4B-3fpcA:
undetectable		 3oy4B-3fpcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 GLY A 158
VAL A 178
SER A 182
THR A 154
 None
None
None
CAC  A 354 (-3.2A)
 0.94A 3tj7A-3fpcA:
undetectable
3tj7B-3fpcA:
undetectable		 3tj7A-3fpcA:
19.94
3tj7B-3fpcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 GLY A 158
VAL A 178
SER A 182
THR A 154
 None
None
None
CAC  A 354 (-3.2A)
 0.94A 3tj7C-3fpcA:
undetectable
3tj7D-3fpcA:
undetectable		 3tj7C-3fpcA:
19.94
3tj7D-3fpcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 6 VAL A 178
SER A 182
THR A 154
GLY A 158
 None
None
CAC  A 354 (-3.2A)
None
 0.96A 3tj7C-3fpcA:
undetectable
3tj7D-3fpcA:
undetectable		 3tj7C-3fpcA:
19.94
3tj7D-3fpcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.85A 3tl9A-3fpcA:
undetectable		 3tl9A-3fpcA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
ASN A 264
GLY A 174
ILE A 175
VAL A 170
 None
 0.85A 3ucbA-3fpcA:
undetectable		 3ucbA-3fpcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 4 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.32A 4d39A-3fpcA:
0.0		 4d39A-3fpcA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 9 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.92A 4q1wA-3fpcA:
undetectable		 4q1wA-3fpcA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 10 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.92A 4q1yA-3fpcA:
undetectable		 4q1yA-3fpcA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 11 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.82A 4qgiA-3fpcA:
undetectable		 4qgiA-3fpcA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		4 / 8 MET A 335
PHE A 334
ALA A   5
LEU A  57
 None
 1.04A 4rkuA-3fpcA:
undetectable
4rkuJ-3fpcA:
undetectable		 4rkuA-3fpcA:
19.13
4rkuJ-3fpcA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 ARG A 301
LEU A 305
VAL A 314
VAL A 178
GLY A 158
 None
 1.07A 5i8fA-3fpcA:
undetectable		 5i8fA-3fpcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 GLY A  23
ASP A  26
ASN A 132
 None
 0.50A 5jglA-3fpcA:
8.1		 5jglA-3fpcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 0.85A 5kqxA-3fpcA:
undetectable		 5kqxA-3fpcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 9 GLY A 211
ALA A 212
ASP A 214
GLY A 192
VAL A 240
 None
 1.00A 5kr0B-3fpcA:
undetectable		 5kr0B-3fpcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		3 / 3 GLY A 263
LEU A 161
HIS A 291
 None
 0.68A 5u63B-3fpcA:
4.3		 5u63B-3fpcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica;
Thermoanaerobact
er
brockii) 		5 / 12 PHE A 120
ASP A  40
ILE A 345
ALA A  33
GLU A  60
 None
None
None
None
ZN  A 353 ( 4.4A)
 1.24A 5vcgA-3fpcA:
undetectable		 5vcgA-3fpcA:
21.00