SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 11 GLU A 175
HIS A 141
LEU A 149
ALA A 143
PHE A 145
 None
 1.16A 1cmaA-3fpkA:
undetectable
1cmaB-3fpkA:
undetectable		 1cmaA-3fpkA:
18.80
1cmaB-3fpkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 10 ALA A 143
PHE A 145
GLU A 175
HIS A 141
LEU A 149
 None
 1.22A 1cmcA-3fpkA:
undetectable
1cmcB-3fpkA:
undetectable		 1cmcA-3fpkA:
18.80
1cmcB-3fpkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 10 GLU A 175
HIS A 141
LEU A 149
ALA A 143
PHE A 145
 None
 1.23A 1cmcA-3fpkA:
undetectable
1cmcB-3fpkA:
undetectable		 1cmcA-3fpkA:
18.80
1cmcB-3fpkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		4 / 8 LEU A  67
ASN A  14
LEU A  82
LEU A  22
 FAD  A 301 (-4.1A)
None
None
None
 0.91A 1e7cA-3fpkA:
undetectable		 1e7cA-3fpkA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		4 / 6 TYR A 121
VAL A 185
ILE A 189
LEU A 109
 None
 1.27A 1j96A-3fpkA:
undetectable		 1j96A-3fpkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A 143
PHE A 145
GLU A 175
HIS A 141
LEU A 149
 None
 1.23A 1mj2A-3fpkA:
undetectable
1mj2B-3fpkA:
undetectable		 1mj2A-3fpkA:
15.94
1mj2B-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A 143
PHE A 145
GLU A 175
HIS A 141
LEU A 149
 None
 1.23A 1mj2C-3fpkA:
undetectable
1mj2D-3fpkA:
undetectable		 1mj2C-3fpkA:
15.94
1mj2D-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A 143
PHE A 145
GLU A 175
HIS A 141
LEU A 149
 None
 1.20A 1mjoC-3fpkA:
undetectable
1mjoD-3fpkA:
undetectable		 1mjoC-3fpkA:
15.94
1mjoD-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 11 GLU A 175
HIS A 141
LEU A 149
ALA A 143
PHE A 145
 None
 1.14A 1mjqA-3fpkA:
undetectable
1mjqB-3fpkA:
undetectable		 1mjqA-3fpkA:
15.94
1mjqB-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 10 GLU A 175
HIS A 141
LEU A 149
ALA A 143
PHE A 145
 None
 1.17A 1mjqC-3fpkA:
undetectable
1mjqD-3fpkA:
undetectable		 1mjqC-3fpkA:
15.94
1mjqD-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 10 GLU A 175
HIS A 141
LEU A 149
ALA A 143
PHE A 145
 None
 1.15A 1mjqG-3fpkA:
undetectable
1mjqH-3fpkA:
undetectable		 1mjqG-3fpkA:
15.94
1mjqH-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 11 GLU A 175
HIS A 141
LEU A 149
ALA A 143
PHE A 145
 None
 1.16A 1mjqI-3fpkA:
undetectable
1mjqJ-3fpkA:
undetectable		 1mjqI-3fpkA:
15.94
1mjqJ-3fpkA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 THR A  69
LEU A  39
LEU A  41
TYR A  52
LEU A  22
 None
None
None
FAD  A 301 (-4.4A)
None
 1.43A 3fsuA-3fpkA:
1.7		 3fsuA-3fpkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 11 ALA A 117
GLY A 213
ALA A  51
LEU A  19
TYR A  52
 None
None
FAD  A 301 (-3.5A)
None
FAD  A 301 (-4.4A)
 1.22A 3rc0A-3fpkA:
undetectable		 3rc0A-3fpkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		3 / 3 SER A  95
GLY A  96
GLN A  35
 None
 0.62A 3v4tH-3fpkA:
undetectable		 3v4tH-3fpkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A  19
GLU A 245
GLY A 115
ALA A 143
LEU A 122
 None
FAD  A 301 ( 4.3A)
None
None
None
 1.19A 4retA-3fpkA:
undetectable		 4retA-3fpkA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A  19
GLU A 245
GLY A 115
ALA A 143
LEU A 122
 None
FAD  A 301 ( 4.3A)
None
None
None
 1.20A 4retC-3fpkA:
undetectable		 4retC-3fpkA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		4 / 7 TYR A 121
VAL A 185
ILE A 189
LEU A 109
 None
 1.00A 4xo7A-3fpkA:
undetectable		 4xo7A-3fpkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 12 GLY A  73
LEU A  82
GLY A   7
LEU A  39
PHE A  20
 FAD  A 301 (-3.2A)
None
None
None
None
 1.27A 4ze1A-3fpkA:
undetectable		 4ze1A-3fpkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 9 SER A  53
THR A 116
CYH A 212
GLY A 213
GLU A 245
 FAD  A 301 (-3.6A)
FAD  A 301 (-3.4A)
None
None
FAD  A 301 ( 4.3A)
 0.80A 5vw4A-3fpkA:
21.8		 5vw4A-3fpkA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		4 / 8 SER A  53
THR A 116
CYH A 212
GLU A 245
 FAD  A 301 (-3.6A)
FAD  A 301 (-3.4A)
None
FAD  A 301 ( 4.3A)
 0.73A 5vw5A-3fpkA:
21.9		 5vw5A-3fpkA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 8 SER A  53
THR A 116
CYH A 212
GLY A 213
GLU A 245
 FAD  A 301 (-3.6A)
FAD  A 301 (-3.4A)
None
None
FAD  A 301 ( 4.3A)
 0.79A 5vw9A-3fpkA:
22.1		 5vw9A-3fpkA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		4 / 4 PRO A 201
MET A 231
GLY A 240
VAL A 209
 None
 1.32A 6ak3A-3fpkA:
undetectable		 6ak3A-3fpkA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3fpk FERREDOXIN-NADP
REDUCTASE
(Salmonella
enterica) 		5 / 11 SER A  53
VAL A 140
LEU A 139
ALA A  33
TYR A 247
 FAD  A 301 (-3.6A)
None
None
None
FAD  A 301 (-3.3A)
 1.28A 6dryA-3fpkA:
undetectable		 6dryA-3fpkA:
22.17