SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 VAL A 256
GLY A 235
ALA A 171
THR A 231
ILE A 255
 None
 1.13A 1gtnL-3fplA:
undetectable
1gtnM-3fplA:
undetectable		 1gtnL-3fplA:
15.35
1gtnM-3fplA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ASN A 264
HIS A  42
TYR A 267
GLY A 243
 None
 1.40A 1mxdA-3fplA:
undetectable		 1mxdA-3fplA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 ASN A 264
HIS A  42
TYR A 267
GLY A 243
 None
 1.32A 1mxgA-3fplA:
undetectable		 1mxgA-3fplA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 LEU A 305
GLY A 185
ALA A 184
LEU A 319
LEU A 316
 None
 0.95A 1nr6A-3fplA:
undetectable		 1nr6A-3fplA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 5 LEU A 351
GLY A 326
HIS A 329
ILE A 330
 None
 0.82A 1xf1A-3fplA:
2.5		 1xf1A-3fplA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 LEU A 351
GLY A 326
HIS A 329
ILE A 330
 None
 0.81A 1xf1B-3fplA:
3.8		 1xf1B-3fplA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ALA A 263
ILE A 262
ILE A 240
VAL A 170
ILE A 227
 None
 0.88A 1xozA-3fplA:
undetectable		 1xozA-3fplA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 11 ASN A 266
VAL A 265
ILE A 262
ALA A 162
ASP A 247
 None
 1.23A 2iyfA-3fplA:
2.3		 2iyfA-3fplA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		6 / 12 GLY A 155
ASN A 264
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.22A 2q64B-3fplA:
undetectable		 2q64B-3fplA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.83A 2qmmA-3fplA:
2.7		 2qmmA-3fplA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 11 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.86A 2qmmA-3fplA:
2.7
2qmmB-3fplA:
2.8		 2qmmA-3fplA:
21.92
2qmmB-3fplA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 ARG A 299
GLY A 298
SER A  92
 None
 0.63A 2xctB-3fplA:
undetectable		 2xctB-3fplA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.03A 3d1zA-3fplA:
undetectable		 3d1zA-3fplA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 VAL A 320
LYS A 346
HIS A 329
 None
 0.93A 3elzA-3fplA:
undetectable		 3elzA-3fplA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
GLY A 158
ALA A 162
ALA A 242
PRO A 177
 None
None
None
None
CL  A 354 (-3.6A)
 1.00A 3jb2A-3fplA:
2.8		 3jb2A-3fplA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 10 GLY A 155
ASN A 264
GLY A 174
ILE A 175
VAL A 170
 None
 0.96A 3lzvA-3fplA:
undetectable		 3lzvA-3fplA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 GLY A 211
ALA A 212
ASP A 214
GLY A 192
ILE A 240
 None
 0.95A 3s53A-3fplA:
undetectable		 3s53A-3fplA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 PRO A 296
VAL A  95
THR A  87
THR A  86
 None
 1.14A 3tneA-3fplA:
undetectable		 3tneA-3fplA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 6 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 None
None
None
None
PGE  A 357 (-4.5A)
 1.23A 4dxuA-3fplA:
undetectable		 4dxuA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 GLY A 260
VAL A 256
PRO A 258
GLY A 282
 None
 0.69A 4forA-3fplA:
undetectable		 4forA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
 None
 1.24A 4obwA-3fplA:
7.7		 4obwA-3fplA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
 None
 1.20A 4obwD-3fplA:
6.8		 4obwD-3fplA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ARG A 301
LEU A 305
VAL A 314
VAL A 178
GLY A 158
 None
None
None
CL  A 354 (-4.0A)
None
 1.18A 5i8fA-3fplA:
undetectable		 5i8fA-3fplA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
None
PGE  A 357 (-4.5A)
None
None
 1.18A 5ih0A-3fplA:
undetectable		 5ih0A-3fplA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 GLY A  23
ASP A  26
ASN A 132
 None
 0.51A 5jglA-3fplA:
8.2		 5jglA-3fplA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 VAL A 348
ILE A 350
VAL A  62
ALA A  33
 None
 0.63A 5ospA-3fplA:
undetectable		 5ospA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 VAL A 348
ILE A 350
VAL A  62
ALA A  33
 None
 0.65A 5osrA-3fplA:
undetectable		 5osrA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 PHE A 120
ASP A  40
ILE A 345
ALA A  33
GLU A  60
 None
None
None
None
ZN  A 352 ( 4.4A)
 1.26A 5vcgA-3fplA:
undetectable		 5vcgA-3fplA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 179
VAL A 204
ILE A 262
GLY A 158
ALA A 171
 None
 1.10A 6c2mA-3fplA:
undetectable		 6c2mA-3fplA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 179
VAL A 204
ILE A 262
GLY A 158
ALA A 171
 None
 1.08A 6c2mB-3fplA:
undetectable		 6c2mB-3fplA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 VAL A 202
LEU A 336
ALA A 347
VAL A 348
SER A  35
 None
 1.11A 6c2mB-3fplA:
undetectable		 6c2mB-3fplA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 ILE A 240
VAL A 183
ALA A 212
THR A 213
 None
 0.95A 6cduC-3fplA:
undetectable
6cduD-3fplA:
undetectable		 6cduC-3fplA:
21.99
6cduD-3fplA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 MET A 140
ALA A 134
LEU A 136
VAL A 323
THR A 149
 None
 1.08A 6djzC-3fplA:
undetectable		 6djzC-3fplA:
21.45