SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpv EXTRACELLULAR
HAEM-BINDING PROTEIN
(Streptomyces
reticuli) 		5 / 12 VAL A  56
VAL A  65
GLY A 131
ALA A 149
LEU A 154
 None
 1.04A 3ku1H-3fpvA:
undetectable		 3ku1H-3fpvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3fpv EXTRACELLULAR
HAEM-BINDING PROTEIN
(Streptomyces
reticuli) 		6 / 12 ALA A 151
ALA A 149
ALA A 152
VAL A 122
ALA A  84
GLY A 133
 None
 1.48A 3mg0Y-3fpvA:
undetectable
3mg0Z-3fpvA:
undetectable		 3mg0Y-3fpvA:
22.42
3mg0Z-3fpvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3fpv EXTRACELLULAR
HAEM-BINDING PROTEIN
(Streptomyces
reticuli) 		5 / 12 LEU A  31
LEU A  29
ALA A  33
LYS A  36
ALA A 130
 None
 1.12A 4x1kA-3fpvA:
undetectable
4x1kB-3fpvA:
undetectable		 4x1kA-3fpvA:
19.68
4x1kB-3fpvA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3fpv EXTRACELLULAR
HAEM-BINDING PROTEIN
(Streptomyces
reticuli) 		4 / 5 SER A  53
VAL A  52
GLY A 136
ALA A 135
 None
None
FE  A 157 ( 4.4A)
FE  A 157 (-3.6A)
 1.02A 5k50A-3fpvA:
undetectable		 5k50A-3fpvA:
22.90