SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.77A 1c9sT-3fpzA:
undetectable
1c9sU-3fpzA:
undetectable		 1c9sT-3fpzA:
16.03
1c9sU-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.75A 1c9sU-3fpzA:
undetectable
1c9sV-3fpzA:
undetectable		 1c9sU-3fpzA:
16.03
1c9sV-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.77A 1gtfL-3fpzA:
undetectable
1gtfM-3fpzA:
undetectable		 1gtfL-3fpzA:
16.03
1gtfM-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.77A 1gtfN-3fpzA:
undetectable
1gtfO-3fpzA:
undetectable		 1gtfN-3fpzA:
16.03
1gtfO-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.82A 1gtnA-3fpzA:
undetectable
1gtnK-3fpzA:
undetectable		 1gtnA-3fpzA:
16.03
1gtnK-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 SER A 277
GLY A  77
ALA A 316
THR A 234
 None
 0.78A 1gtnA-3fpzA:
undetectable
1gtnB-3fpzA:
undetectable		 1gtnA-3fpzA:
16.03
1gtnB-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.72A 1gtnP-3fpzA:
undetectable
1gtnQ-3fpzA:
undetectable		 1gtnP-3fpzA:
16.03
1gtnQ-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 165
TYR A  56
LEU A  60
THR A 168
 None
 1.23A 1rmtB-3fpzA:
undetectable		 1rmtB-3fpzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.81A 1utdB-3fpzA:
undetectable
1utdC-3fpzA:
undetectable		 1utdB-3fpzA:
16.03
1utdC-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.79A 1utdF-3fpzA:
undetectable
1utdG-3fpzA:
undetectable		 1utdF-3fpzA:
16.03
1utdG-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.78A 1utdJ-3fpzA:
undetectable
1utdK-3fpzA:
undetectable		 1utdJ-3fpzA:
16.03
1utdK-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 102
GLY A  74
ILE A  70
GLY A  72
 None
AHZ  A1100 (-3.6A)
None
AHZ  A1100 (-3.3A)
 0.86A 2jkjA-3fpzA:
undetectable		 2jkjA-3fpzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 102
GLY A  74
ILE A  70
GLY A  72
 None
AHZ  A1100 (-3.6A)
None
AHZ  A1100 (-3.3A)
 0.86A 2jkjB-3fpzA:
undetectable		 2jkjB-3fpzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 102
GLY A  74
ILE A  70
GLY A  72
 None
AHZ  A1100 (-3.6A)
None
AHZ  A1100 (-3.3A)
 0.87A 2jkjC-3fpzA:
undetectable		 2jkjC-3fpzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		3 / 3 SER A  79
HIS A 123
ASP A 138
 None
 0.75A 2oxtA-3fpzA:
undetectable		 2oxtA-3fpzA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 316
THR A 234
ALA A  80
GLY A 313
SER A 312
 None
 1.38A 2xfsB-3fpzA:
undetectable		 2xfsB-3fpzA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 SER A 312
THR A 234
ALA A 316
GLY A 313
ALA A  80
 None
 1.27A 2xh9A-3fpzA:
undetectable		 2xh9A-3fpzA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 10 SER A 312
THR A 234
ALA A 316
GLY A 313
ALA A  80
 None
 1.25A 2xh9B-3fpzA:
undetectable		 2xh9B-3fpzA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 4 SER A 277
GLY A 278
GLY A 290
GLY A 313
 None
None
AHZ  A1100 (-3.5A)
None
 0.93A 3bogB-3fpzA:
undetectable
3bogD-3fpzA:
undetectable		 3bogB-3fpzA:
undetectable
3bogD-3fpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  80
VAL A  68
ILE A 320
GLY A 278
VAL A  71
ILE A  70
 None
None
None
None
AHZ  A1100 ( 4.9A)
None
 1.40A 3bvbA-3fpzA:
undetectable		 3bvbA-3fpzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  80
GLY A 313
HIS A 315
LEU A  78
SER A  75
 None
None
None
None
AHZ  A1100 (-3.6A)
 1.41A 3bxoB-3fpzA:
2.3		 3bxoB-3fpzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 290
GLY A  74
SER A  75
MET A 309
ALA A 243
 AHZ  A1100 (-3.5A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
 1.07A 3ou6A-3fpzA:
undetectable		 3ou6A-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 290
GLY A  74
SER A  75
MET A 309
ALA A 243
 AHZ  A1100 (-3.5A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
 1.05A 3ou6B-3fpzA:
2.2		 3ou6B-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 289
GLY A  77
SER A  75
MET A 309
LEU A 232
 None
None
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
 1.23A 3ou7A-3fpzA:
2.1		 3ou7A-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 290
GLY A  74
SER A  75
MET A 309
ALA A 243
 AHZ  A1100 (-3.5A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
 1.05A 3ou7B-3fpzA:
2.1		 3ou7B-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 289
GLY A  77
SER A  75
MET A 309
LEU A 232
 None
None
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
 1.21A 3ou7C-3fpzA:
2.1		 3ou7C-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 289
GLY A  77
SER A  75
MET A 309
LEU A 232
 None
None
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
 1.19A 3ou7D-3fpzA:
undetectable		 3ou7D-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  80
GLY A 313
HIS A 315
LEU A  78
SER A  75
 None
None
None
None
AHZ  A1100 (-3.6A)
 1.38A 3pfgA-3fpzA:
undetectable		 3pfgA-3fpzA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 156
ALA A 317
PHE A 125
LEU A 147
PHE A 148
 None
 1.32A 4iaqA-3fpzA:
undetectable		 4iaqA-3fpzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 298
VAL A 273
ALA A 308
MET A 309
ASP A 265
 None
None
None
AHZ  A1100 (-3.3A)
None
 1.44A 4l9iB-3fpzA:
undetectable		 4l9iB-3fpzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qvlV-3fpzA:
undetectable
4qvlb-3fpzA:
undetectable		 4qvlV-3fpzA:
20.00
4qvlb-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qvlH-3fpzA:
undetectable
4qvlN-3fpzA:
undetectable		 4qvlH-3fpzA:
20.00
4qvlN-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.48A 4qvmV-3fpzA:
undetectable
4qvmb-3fpzA:
undetectable		 4qvmV-3fpzA:
20.00
4qvmb-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.49A 4qvpV-3fpzA:
undetectable
4qvpb-3fpzA:
undetectable		 4qvpV-3fpzA:
20.00
4qvpb-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.48A 4qvpH-3fpzA:
undetectable
4qvpN-3fpzA:
undetectable		 4qvpH-3fpzA:
20.00
4qvpN-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qvqV-3fpzA:
undetectable
4qvqb-3fpzA:
undetectable		 4qvqV-3fpzA:
20.00
4qvqb-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qvqH-3fpzA:
undetectable
4qvqN-3fpzA:
undetectable		 4qvqH-3fpzA:
20.00
4qvqN-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.46A 4qw3V-3fpzA:
undetectable
4qw3b-3fpzA:
undetectable		 4qw3V-3fpzA:
20.00
4qw3b-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qw3H-3fpzA:
undetectable
4qw3N-3fpzA:
undetectable		 4qw3H-3fpzA:
20.00
4qw3N-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qwuV-3fpzA:
undetectable
4qwub-3fpzA:
undetectable		 4qwuV-3fpzA:
20.00
4qwub-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 4qwuH-3fpzA:
undetectable
4qwuN-3fpzA:
undetectable		 4qwuH-3fpzA:
20.00
4qwuN-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 307
ALA A 308
SER A 277
ILE A 275
VAL A 314
 None
 1.05A 4r21B-3fpzA:
undetectable		 4r21B-3fpzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  77
GLY A 313
ALA A 317
ILE A  95
LEU A  78
 None
 1.22A 5bw4B-3fpzA:
4.0		 5bw4B-3fpzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.41A 5bxnV-3fpzA:
undetectable
5bxnb-3fpzA:
undetectable		 5bxnV-3fpzA:
20.00
5bxnb-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.41A 5bxnH-3fpzA:
undetectable
5bxnN-3fpzA:
undetectable		 5bxnH-3fpzA:
20.00
5bxnN-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.48A 5d0xH-3fpzA:
undetectable
5d0xN-3fpzA:
undetectable		 5d0xH-3fpzA:
20.00
5d0xN-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 SER A 277
GLY A  77
ALA A 316
THR A 234
 None
 0.78A 5eezL-3fpzA:
undetectable
5eezV-3fpzA:
undetectable		 5eezL-3fpzA:
16.03
5eezV-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 SER A 277
GLY A  77
ALA A 316
THR A 234
 None
 0.78A 5ef1L-3fpzA:
undetectable
5ef1V-3fpzA:
undetectable		 5ef1L-3fpzA:
16.03
5ef1V-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 SER A 277
GLY A  77
ALA A 316
THR A 234
 None
 0.78A 5ef2L-3fpzA:
undetectable
5ef2V-3fpzA:
undetectable		 5ef2L-3fpzA:
16.03
5ef2V-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 290
GLY A  74
SER A  75
MET A 309
HIS A 237
 AHZ  A1100 (-3.5A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
AHZ  A1100 (-4.4A)
 1.25A 5hikA-3fpzA:
undetectable		 5hikA-3fpzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 182
THR A 179
GLY A  72
LEU A 173
 None
None
AHZ  A1100 (-3.3A)
None
 0.78A 5jlcA-3fpzA:
undetectable		 5jlcA-3fpzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 9 ALA A  80
ILE A 320
GLY A 278
VAL A  71
ILE A  70
 None
None
None
AHZ  A1100 ( 4.9A)
None
 1.17A 5kr0A-3fpzA:
undetectable		 5kr0A-3fpzA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 5l66V-3fpzA:
undetectable
5l66b-3fpzA:
undetectable		 5l66V-3fpzA:
20.00
5l66b-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 315
SER A 277
GLY A  77
ALA A 289
THR A 234
 None
 1.47A 5l66H-3fpzA:
undetectable
5l66N-3fpzA:
undetectable		 5l66H-3fpzA:
20.00
5l66N-3fpzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  85
ILE A 320
ALA A 317
LEU A 321
 None
 0.84A 5te8B-3fpzA:
undetectable		 5te8B-3fpzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 289
GLY A  77
GLY A  74
ILE A 149
LEU A 126
 None
None
AHZ  A1100 (-3.6A)
None
None
 1.05A 5ul4A-3fpzA:
undetectable		 5ul4A-3fpzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 296
VAL A 250
ASP A 253
 None
 0.62A 5x23A-3fpzA:
undetectable		 5x23A-3fpzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 148
GLY A  77
GLY A 313
ALA A 316
ILE A  95
 None
 1.10A 6b3aA-3fpzA:
undetectable		 6b3aA-3fpzA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 148
GLY A  77
GLY A 313
ALA A 316
ILE A  95
 None
 1.11A 6b3bA-3fpzA:
undetectable		 6b3bA-3fpzA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3fpz THIAZOLE
BIOSYNTHETIC ENZYME
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 129
LEU A 126
LEU A  78
GLY A  74
 None
None
None
AHZ  A1100 (-3.6A)
 0.92A 6ce2A-3fpzA:
undetectable		 6ce2A-3fpzA:
18.80