SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 4 ALA A1345
ARG A1427
GLN A1348
GLU A1349
 None
 1.29A 1lqtB-3fq8A:
undetectable		 1lqtB-3fq8A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 4 ALA A1345
ARG A1427
GLN A1348
GLU A1349
 None
 1.28A 1lquB-3fq8A:
undetectable		 1lquB-3fq8A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 ILE A1275
PHE A1119
ALA A1312
VAL A1111
ILE A1114
 None
 1.07A 3e00A-3fq8A:
undetectable		 3e00A-3fq8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 10 ILE A1275
PHE A1119
ALA A1312
VAL A1111
ILE A1114
 None
 1.06A 3falA-3fq8A:
undetectable		 3falA-3fq8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		3 / 3 SER A1122
GLY A1123
THR A1124
 PMP  A5000 (-3.8A)
PMP  A5000 (-3.3A)
PMP  A5000 (-3.5A)
 0.12A 3k9wA-3fq8A:
undetectable		 3k9wA-3fq8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.44A 3p97A-3fq8A:
undetectable		 3p97A-3fq8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 7 LEU A1332
SER A1411
GLU A1416
HIS A1414
 None
 1.27A 4aq7A-3fq8A:
undetectable		 4aq7A-3fq8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.43A 4ctjA-3fq8A:
undetectable		 4ctjA-3fq8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 8 GLY A1068
GLY A1278
LEU A1279
VAL A1281
 None
 0.84A 4fgzA-3fq8A:
undetectable		 4fgzA-3fq8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 8 GLY A1068
GLY A1278
LEU A1279
VAL A1281
 None
 0.82A 4fgzB-3fq8A:
undetectable		 4fgzB-3fq8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 ALA A1161
PHE A1157
ILE A1143
ARG A1135
LEU A1131
 None
 1.01A 4kjkA-3fq8A:
undetectable		 4kjkA-3fq8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 ALA A1161
PHE A1157
ILE A1143
ARG A1135
LEU A1131
 None
 1.02A 4x5hA-3fq8A:
undetectable		 4x5hA-3fq8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.42A 5e9qA-3fq8A:
undetectable		 5e9qA-3fq8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.48A 5ec8C-3fq8A:
undetectable		 5ec8C-3fq8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.43A 5eifA-3fq8A:
undetectable		 5eifA-3fq8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 5 PHE A1220
ILE A1214
MET A1362
GLN A1358
 None
 1.41A 5jm4A-3fq8A:
undetectable		 5jm4A-3fq8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.48A 5njvA-3fq8A:
undetectable		 5njvA-3fq8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 10 PRO A1069
GLY A1282
GLY A1123
LEU A1279
ALA A1312
 None
None
PMP  A5000 (-3.3A)
None
None
 0.99A 5o96E-3fq8A:
undetectable
5o96F-3fq8A:
undetectable		 5o96E-3fq8A:
20.37
5o96F-3fq8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A1282
GLY A1316
GLY A1277
GLY A1272
THR A1319
ILE A1317
 None
 1.46A 5wz2B-3fq8A:
undetectable		 5wz2B-3fq8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 ALA A1283
VAL A1107
MET A1106
GLY A1316
ALA A1315
 None
 1.25A 5x23A-3fq8A:
undetectable		 5x23A-3fq8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 LEU A1320
GLY A1257
ALA A1110
PHE A1262
THR A1249
 None
 1.33A 5x6yA-3fq8A:
undetectable		 5x6yA-3fq8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 6 GLY A1164
LEU A1168
PHE A1034
PHE A1044
 None
 0.87A 6h7lA-3fq8A:
undetectable		 6h7lA-3fq8A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 6 GLY A1164
LEU A1168
VAL A1064
PHE A1034
 None
 0.79A 6h7lA-3fq8A:
undetectable		 6h7lA-3fq8A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 6 GLY A1164
LEU A1168
PHE A1034
PHE A1044
 None
 0.86A 6h7lB-3fq8A:
undetectable		 6h7lB-3fq8A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 6 GLY A1164
LEU A1168
VAL A1064
PHE A1034
 None
 0.79A 6h7lB-3fq8A:
undetectable		 6h7lB-3fq8A:
13.05