SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER B 192
LEU B 194
LEU B 338
LEU B 316
ILE B 323
 None
 1.21A 1ee2A-3fqdB:
undetectable		 1ee2A-3fqdB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER B 192
LEU B 194
LEU B 338
LEU B 316
ILE B 323
 None
 1.21A 1ee2B-3fqdB:
undetectable		 1ee2B-3fqdB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.92A 1grmA-3fqdA:
undetectable		 1grmA-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.92A 1grmB-3fqdA:
undetectable		 1grmB-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 684
PRO A 685
LEU A 688
 None
 0.53A 1hrkA-3fqdA:
undetectable		 1hrkA-3fqdA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A 627
HIS A 208
GLU A 205
LEU A 241
 None
 1.03A 1j96B-3fqdA:
undetectable		 1j96B-3fqdA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.89A 1jnoA-3fqdA:
undetectable		 1jnoA-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.89A 1jnoB-3fqdA:
undetectable		 1jnoB-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.93A 1jo3A-3fqdA:
undetectable		 1jo3A-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.92A 1jo3B-3fqdA:
undetectable		 1jo3B-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.87A 1jo4A-3fqdA:
undetectable		 1jo4A-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.87A 1jo4B-3fqdA:
undetectable		 1jo4B-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.88A 1magA-3fqdA:
undetectable		 1magA-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.88A 1magB-3fqdA:
undetectable		 1magB-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.91A 1ng8A-3fqdA:
undetectable		 1ng8A-3fqdA:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.91A 1ng8B-3fqdA:
undetectable		 1ng8B-3fqdA:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.91A 1nrmA-3fqdA:
undetectable		 1nrmA-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.91A 1nrmB-3fqdA:
undetectable		 1nrmB-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.93A 1nruA-3fqdA:
undetectable		 1nruA-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  81
VAL A  60
TRP A 157
 None
 0.92A 1nruB-3fqdA:
undetectable		 1nruB-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		4 / 6 TRP B 322
PHE B   5
GLU B 321
ILE B 323
 None
 1.46A 1nsiA-3fqdB:
undetectable
1nsiB-3fqdB:
undetectable		 1nsiA-3fqdB:
21.96
1nsiB-3fqdB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		4 / 6 TRP B 322
PHE B   5
GLU B 321
ILE B 323
 None
 1.49A 1nsiC-3fqdB:
undetectable
1nsiD-3fqdB:
undetectable		 1nsiC-3fqdB:
21.96
1nsiD-3fqdB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 585
TYR A 587
LYS A 399
 None
 0.98A 1uujB-3fqdA:
undetectable		 1uujB-3fqdA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 6 ILE A 239
VAL A 252
VAL A  60
ILE A 162
ASP A  55
 None
 1.35A 1uwhB-3fqdA:
undetectable		 1uwhB-3fqdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE A 394
TYR A 617
VAL A 387
GLY A 388
LEU A 344
 None
 1.39A 2bxeA-3fqdA:
undetectable		 2bxeA-3fqdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.41A 2dysA-3fqdA:
undetectable
2dysC-3fqdA:
undetectable		 2dysA-3fqdA:
18.36
2dysC-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.39A 2eikA-3fqdA:
undetectable
2eikC-3fqdA:
undetectable		 2eikA-3fqdA:
18.36
2eikC-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.41A 2eilA-3fqdA:
undetectable
2eilC-3fqdA:
undetectable		 2eilA-3fqdA:
18.36
2eilC-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.37A 2eimA-3fqdA:
undetectable
2eimC-3fqdA:
undetectable		 2eimA-3fqdA:
18.36
2eimC-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.32A 2eimN-3fqdA:
undetectable
2eimP-3fqdA:
undetectable		 2eimN-3fqdA:
18.36
2eimP-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 214
TRP B 159
LEU A 852
TYR A 223
GLU A 247
 None
 1.46A 2no0B-3fqdA:
undetectable		 2no0B-3fqdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE B 323
TRP B 322
PHE B   5
GLU B 321
 None
 1.48A 2nsiA-3fqdB:
undetectable
2nsiB-3fqdB:
undetectable		 2nsiA-3fqdB:
21.96
2nsiB-3fqdB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  50
ASN A  51
THR A 245
 None
 0.55A 2pymB-3fqdA:
undetectable		 2pymB-3fqdA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  50
ASN A  51
THR A 245
 None
 0.62A 2q63B-3fqdA:
undetectable		 2q63B-3fqdA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 319
ARG A 301
ILE A 346
LEU A 354
 None
 0.90A 2xkwB-3fqdA:
undetectable		 2xkwB-3fqdA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.43A 3abkA-3fqdA:
undetectable
3abkC-3fqdA:
undetectable		 3abkA-3fqdA:
18.36
3abkC-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.40A 3abkN-3fqdA:
undetectable
3abkP-3fqdA:
undetectable		 3abkN-3fqdA:
18.36
3abkP-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.42A 3ag1A-3fqdA:
undetectable
3ag1C-3fqdA:
undetectable		 3ag1A-3fqdA:
18.36
3ag1C-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.41A 3ag2A-3fqdA:
undetectable
3ag2C-3fqdA:
undetectable		 3ag2A-3fqdA:
18.36
3ag2C-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.42A 3ag3A-3fqdA:
undetectable
3ag3C-3fqdA:
undetectable		 3ag3A-3fqdA:
18.36
3ag3C-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.42A 3ag3N-3fqdA:
undetectable
3ag3P-3fqdA:
undetectable		 3ag3N-3fqdA:
18.36
3ag3P-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 246
THR A 370
TYR A 368
HIS A 847
 None
 1.41A 3ag4A-3fqdA:
undetectable
3ag4C-3fqdA:
undetectable		 3ag4A-3fqdA:
18.36
3ag4C-3fqdA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO B 177
PHE B  58
LYS B 148
 None
 1.01A 3bjwG-3fqdB:
undetectable		 3bjwG-3fqdB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE B 184
ILE B  72
SER B  73
LYS B  76
ILE B 195
 None
 0.87A 3cd2A-3fqdB:
undetectable		 3cd2A-3fqdB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 332
LEU A 384
ALA A 380
VAL A 624
VAL A 375
 None
 1.26A 3cwkA-3fqdA:
undetectable		 3cwkA-3fqdA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 11 ASP A 237
ILE A 346
GLY A 334
LEU A 338
VAL A 327
 None
 0.87A 3em4U-3fqdA:
undetectable		 3em4U-3fqdA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 133
GLU A 132
LYS A 268
LEU A 272
 None
 0.92A 3h5gA-3fqdA:
undetectable
3h5gC-3fqdA:
undetectable		 3h5gA-3fqdA:
2.90
3h5gC-3fqdA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 11 LYS A 599
GLY A 720
PHE A 716
ASP A 710
ILE A 709
 None
 1.29A 3id5B-3fqdA:
3.0		 3id5B-3fqdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 11 LYS A 599
GLY A 720
PHE A 716
ASP A 710
ILE A 709
 None
 1.30A 3id5F-3fqdA:
undetectable		 3id5F-3fqdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A 639
GLY A 620
PHE A 337
HIS A 642
PHE A 726
 None
 1.47A 3s8pB-3fqdA:
0.1		 3s8pB-3fqdA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 8 TRP A 326
LEU A   9
ILE A 346
GLY A 334
 None
 0.91A 3wxoA-3fqdA:
undetectable		 3wxoA-3fqdA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 229
ASN A  51
TYR A  53
LEU A  98
 None
 1.14A 4awuA-3fqdA:
undetectable		 4awuA-3fqdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 238
LEU A 241
GLY A 242
THR A 245
 None
 0.73A 4c9nA-3fqdA:
undetectable		 4c9nA-3fqdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 ALA A 380
PHE A 332
LEU A 369
THR A 370
 None
 0.64A 4du2A-3fqdA:
undetectable		 4du2A-3fqdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 ALA A 380
PHE A 332
LEU A 369
THR A 370
 None
 0.61A 4du2B-3fqdA:
undetectable		 4du2B-3fqdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 691
LEU A 688
LEU A 743
ILE A 699
SER A 748
 None
 1.11A 4f4dB-3fqdA:
2.7		 4f4dB-3fqdA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 582
ASP A 403
ARG A 405
GLU A 588
 None
 1.18A 4gkhF-3fqdA:
undetectable		 4gkhF-3fqdA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU A 762
ASP A 830
GLN A 832
ILE A 181
 None
 1.16A 4ii8A-3fqdA:
undetectable		 4ii8A-3fqdA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 388
ALA A 647
TYR A 617
LEU A 344
ILE A 357
 None
 1.30A 4pb1A-3fqdA:
undetectable		 4pb1A-3fqdA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B  53
GLY B 281
ASP B 278
 None
 0.68A 4xdtA-3fqdB:
undetectable		 4xdtA-3fqdB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 243
VAL A 327
ILE A 330
LEU A 295
LEU A  10
 None
 1.32A 4yvpB-3fqdA:
undetectable		 4yvpB-3fqdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 621
TYR A 617
VAL A 375
LEU A 344
LEU A 354
 None
 1.25A 4yvpB-3fqdA:
undetectable		 4yvpB-3fqdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A 368
MET A 240
LEU A 300
TRP A 358
PHE A 329
 None
 1.47A 4yvxB-3fqdA:
undetectable		 4yvxB-3fqdA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE B 294
TRP B 261
LEU B 312
CYH B 102
TYR B 251
 None
 1.12A 5fctB-3fqdB:
undetectable		 5fctB-3fqdB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE B 167
ARG B 170
CYH B 162
GLU B 157
 None
 1.39A 5fseC-3fqdB:
undetectable		 5fseC-3fqdB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 LYS A 111
ALA A 110
VAL A 624
TYR A 627
 None
 0.81A 5i8fA-3fqdA:
undetectable		 5i8fA-3fqdA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 387
SER A 343
GLY A 349
ALA A 350
LEU A 354
 None
 1.13A 5jvzB-3fqdA:
undetectable		 5jvzB-3fqdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 ARG A 194
LEU A  98
PHE A 213
ARG A 218
HIS A 847
 None
 1.17A 5k7uA-3fqdA:
undetectable		 5k7uA-3fqdA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B 118
ASN B  87
GLN B  85
 None
 0.82A 5k7uA-3fqdB:
undetectable		 5k7uA-3fqdB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG A 218
GLU A 247
GLY A 854
TRP B 159
 None
 1.03A 5kgpA-3fqdA:
undetectable		 5kgpA-3fqdA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3fqd 5'-3'
EXORIBONUCLEASE 2
PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG A 218
GLU A 247
GLY A 854
TRP B 159
 None
 1.02A 5kgpB-3fqdA:
undetectable		 5kgpB-3fqdA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 196
THR A 756
PHE A 100
GLN A 217
SER A 216
 None
 1.24A 5l8oB-3fqdA:
undetectable		 5l8oB-3fqdA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A  54
ILE A  59
GLY A  58
VAL A 252
LEU A 253
 None
 0.97A 5o96C-3fqdA:
2.1
5o96D-3fqdA:
2.2		 5o96C-3fqdA:
13.95
5o96D-3fqdA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A 179
LEU A 758
PHE A 195
LEU A 197
 None
 0.96A 5tl8A-3fqdA:
undetectable		 5tl8A-3fqdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 328
ASP A 324
LEU A 238
 None
 0.73A 5uhcC-3fqdA:
undetectable		 5uhcC-3fqdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A   3
PHE A   7
ILE A 239
LEU A 295
VAL A 257
 None
 0.90A 5uvmB-3fqdA:
undetectable		 5uvmB-3fqdA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 9 ILE A 101
LYS A 209
ILE A 210
ILE A 214
 None
 0.76A 5vkqB-3fqdA:
undetectable
5vkqC-3fqdA:
undetectable		 5vkqB-3fqdA:
19.94
5vkqC-3fqdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 6 SER A 159
ALA A 679
SER A 680
ALA A 126
SER A 123
 None
 1.32A 6bocA-3fqdA:
undetectable
6bocB-3fqdA:
undetectable
6bocC-3fqdA:
undetectable
6bocD-3fqdA:
undetectable		 6bocA-3fqdA:
2.72
6bocB-3fqdA:
2.72
6bocC-3fqdA:
2.72
6bocD-3fqdA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3fqd 5'-3'
EXORIBONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 327
VAL A 624
GLY A 620
ASN A 335
VAL A 333
 None
 1.18A 6bqgA-3fqdA:
undetectable		 6bqgA-3fqdA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3fqd PROTEIN DIN1
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU B 235
ASP B 201
ILE B 273
 None
MG  B1000 (-2.8A)
None
 0.48A 6dh0B-3fqdB:
undetectable		 6dh0B-3fqdB:
11.01