SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 7 LEU A 292
ALA A 291
PHE A 277
VAL A 279
 None
 0.90A 1epbA-3fr8A:
undetectable		 1epbA-3fr8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 LEU A 323
LEU A 479
ILE A 490
GLU A 496
 None
None
None
MG  A   1 ( 3.0A)
 1.00A 1mt1A-3fr8A:
undetectable
1mt1F-3fr8A:
undetectable		 1mt1A-3fr8A:
7.47
1mt1F-3fr8A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 ILE A 490
GLU A 496
LEU A 323
LEU A 479
 None
MG  A   1 ( 3.0A)
None
None
 0.93A 1mt1B-3fr8A:
undetectable
1mt1C-3fr8A:
undetectable		 1mt1B-3fr8A:
11.83
1mt1C-3fr8A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 7 LEU A 323
LEU A 479
ILE A 490
GLU A 496
 None
None
None
MG  A   1 ( 3.0A)
 1.01A 1n13I-3fr8A:
undetectable
1n13L-3fr8A:
undetectable		 1n13I-3fr8A:
7.47
1n13L-3fr8A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 12 ILE A 360
GLY A 368
VAL A 372
ALA A 566
TYR A 468
 None
 1.38A 1nbhA-3fr8A:
4.1		 1nbhA-3fr8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 12 ILE A 360
GLY A 368
VAL A 372
ALA A 566
TYR A 468
 None
 1.38A 1nbhD-3fr8A:
3.8		 1nbhD-3fr8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 8 GLY A 231
PHE A 228
ASP A 315
THR A 520
 None
None
MG  A   1 ( 3.5A)
None
 0.93A 2aouA-3fr8A:
undetectable		 2aouA-3fr8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 7 GLY A 231
PHE A 228
ASP A 315
THR A 520
 None
None
MG  A   1 ( 3.5A)
None
 1.02A 2aouB-3fr8A:
4.2		 2aouB-3fr8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 12 GLY A 272
GLY A 299
GLY A 110
ARG A 259
ILE A 579
 None
 1.01A 2b25A-3fr8A:
3.0		 2b25A-3fr8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		3 / 3 ASN A 516
ILE A 436
MET A 433
 None
 0.76A 2h42C-3fr8A:
undetectable		 2h42C-3fr8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 7 LEU A 323
LEU A 479
ILE A 490
GLU A 496
 None
None
None
MG  A   1 ( 3.0A)
 1.03A 2qqdA-3fr8A:
undetectable
2qqdE-3fr8A:
undetectable		 2qqdA-3fr8A:
11.20
2qqdE-3fr8A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 8 VAL A 469
TYR A 388
VAL A 563
VAL A 494
 None
 1.00A 2y05A-3fr8A:
5.0
2y05B-3fr8A:
5.1		 2y05A-3fr8A:
23.70
2y05B-3fr8A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		3 / 3 PHE A 302
ASN A 274
PHE A 304
 None
 1.01A 2zbuD-3fr8A:
undetectable		 2zbuD-3fr8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 8 LEU A 298
SER A 300
THR A 303
ALA A 291
 None
 0.98A 3ax9A-3fr8A:
undetectable		 3ax9A-3fr8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 8 LEU A 298
SER A 300
THR A 303
ALA A 291
 None
 1.01A 3ax9B-3fr8A:
undetectable		 3ax9B-3fr8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 12 GLY A 318
VAL A 478
LEU A 399
LEU A 323
LEU A 501
 None
 1.39A 3cjtK-3fr8A:
undetectable		 3cjtK-3fr8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 PHE A 463
ALA A 387
ALA A 540
THR A 543
 SO4  A 597 (-3.6A)
None
None
None
 1.02A 4dtzA-3fr8A:
undetectable		 4dtzA-3fr8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 12 GLN A 205
LEU A 198
VAL A 130
ILE A 131
LEU A 161
 NDP  A 601 (-3.7A)
None
None
None
None
 1.49A 4k38A-3fr8A:
undetectable
4k38D-3fr8A:
undetectable		 4k38A-3fr8A:
21.40
4k38D-3fr8A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 9 LEU A 479
ASN A 491
GLU A 492
GLN A 310
SER A 314
 None
None
MG  A   1 (-3.3A)
None
None
 1.27A 4omwD-3fr8A:
undetectable		 4omwD-3fr8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 11 LEU A 224
ILE A 412
GLY A 231
HIS A 232
LEU A 233
 None
 1.20A 4pxmB-3fr8A:
undetectable		 4pxmB-3fr8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		3 / 3 PRO A 394
MET A 396
TYR A 393
 None
 0.95A 4qa2B-3fr8A:
2.0		 4qa2B-3fr8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 ASN A 491
GLU A 488
TYR A 486
GLU A 105
 None
 1.45A 4r87H-3fr8A:
undetectable		 4r87H-3fr8A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 10 GLY A 223
ALA A 297
ILE A 128
LEU A 197
LEU A 195
 None
 0.98A 4xj7A-3fr8A:
2.3
4xj7B-3fr8A:
2.2		 4xj7A-3fr8A:
19.58
4xj7B-3fr8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 10 LEU A 197
LEU A 195
GLY A 223
ALA A 297
ILE A 128
 None
 1.04A 4xj7C-3fr8A:
2.4
4xj7D-3fr8A:
2.3		 4xj7C-3fr8A:
19.58
4xj7D-3fr8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 7 VAL A 258
ILE A 273
LEU A 324
LEU A 501
 None
 1.03A 4xo7A-3fr8A:
undetectable		 4xo7A-3fr8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 LEU A 144
SER A 295
PRO A 251
GLU A 311
 None
 1.26A 5b8iA-3fr8A:
undetectable		 5b8iA-3fr8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 8 LEU A 118
LEU A 298
ILE A 107
THR A 303
 None
 0.99A 5ljbA-3fr8A:
undetectable		 5ljbA-3fr8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 PHE A 504
ASN A 502
ARG A 508
GLY A 509
 None
 0.87A 5o4yA-3fr8A:
undetectable		 5o4yA-3fr8A:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		5 / 12 LEU A 199
GLY A 137
GLY A 134
GLN A 136
LEU A 298
 NDP  A 601 (-4.7A)
None
NDP  A 601 (-3.7A)
NDP  A 601 (-4.1A)
None
 1.18A 5uc1A-3fr8A:
undetectable		 5uc1A-3fr8A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)
(Oryza
sativa) 		4 / 6 PHE A 122
LEU A 118
ALA A 121
THR A 303
 None
 0.95A 6f88A-3fr8A:
undetectable		 6f88A-3fr8A:
10.77