SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3frk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 THR A 199
GLU A  42
ASP A  36
 None
 0.68A 1nt2A-3frkA:
2.1		 1nt2A-3frkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 10 LEU A 307
SER A 342
PHE A   5
THR A 284
ALA A 185
 TQP  A 374 (-4.8A)
None
None
None
TQP  A 374 (-3.3A)
 1.37A 1wygA-3frkA:
undetectable		 1wygA-3frkA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 GLY A 194
GLY A 179
PHE A  45
PHE A  41
 None
 0.91A 2qx6A-3frkA:
undetectable
2qx6B-3frkA:
undetectable		 2qx6A-3frkA:
21.01
2qx6B-3frkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 GLY A 179
VAL A 197
LEU A 174
MET A 140
LEU A 154
 None
 1.35A 3h52D-3frkA:
undetectable		 3h52D-3frkA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TYR A 277
ASP A 113
ASP A 139
 None
 0.84A 3r24A-3frkA:
undetectable		 3r24A-3frkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 11 PHE A 285
ASN A 362
ILE A 361
GLY A 263
ALA A 262
 None
 1.19A 3rukD-3frkA:
undetectable		 3rukD-3frkA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 ASP A 106
TYR A 110
PRO A 105
ARG A 288
 None
 0.93A 3s3oA-3frkA:
undetectable		 3s3oA-3frkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 PHE A 285
ASN A 362
ILE A 361
GLY A 263
ALA A 262
 None
 1.06A 4nkxA-3frkA:
undetectable		 4nkxA-3frkA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 PHE A 285
ASN A 362
ILE A 361
GLY A 263
ALA A 262
 None
 1.05A 4nkxC-3frkA:
undetectable		 4nkxC-3frkA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 PHE A 285
ASN A 362
ILE A 361
GLY A 263
ALA A 262
 None
 1.10A 4nkxD-3frkA:
undetectable		 4nkxD-3frkA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NMY_A_VIBA401_1
(ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 11 TYR A 283
SER A 342
PHE A   5
TYR A 134
THR A 284
 None
 1.47A 4nmyA-3frkA:
0.0		 4nmyA-3frkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ASP A 157
LEU A  61
GLY A  60
 TQP  A 374 (-2.8A)
TQP  A 374 (-4.0A)
TQP  A 374 (-3.2A)
 0.55A 4xmfA-3frkA:
undetectable		 4xmfA-3frkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 ILE A 358
LEU A 295
LEU A 341
ILE A 343
 None
 0.73A 4xtaB-3frkA:
undetectable		 4xtaB-3frkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 5 PRO A 331
GLY A 328
THR A 327
ASN A 329
 None
 0.89A 5x23A-3frkA:
undetectable		 5x23A-3frkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 PRO A 331
GLY A 328
THR A 327
ASN A 329
 None
 0.95A 5x24A-3frkA:
undetectable		 5x24A-3frkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 PRO A 331
GLY A 328
THR A 327
ASN A 329
 None
 1.06A 5xxiA-3frkA:
undetectable		 5xxiA-3frkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3frk QDTB
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 GLY A  60
GLY A 179
SER A 212
LEU A 231
GLY A 195
GLY A  58
 TQP  A 374 (-3.2A)
None
None
None
None
None
 1.40A 5zhmB-3frkA:
undetectable		 5zhmB-3frkA:
21.99