SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3frq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		3 / 3 LEU A  55
PHE A  28
ARG A  47
 None
 0.84A 1xdkB-3frqA:
undetectable		 1xdkB-3frqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		3 / 3 LEU A 115
TYR A 108
GLN A 111
 None
 0.74A 2wekA-3frqA:
undetectable		 2wekA-3frqA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		11 / 12 THR A  17
LYS A  21
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
TYR A 103
VAL A 126
ILE A 150
THR A 154
 ERY  A 195 (-4.4A)
CL  A 198 ( 4.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
ERY  A 195 ( 4.1A)
 0.02A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		11 / 12 THR A  17
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
TYR A 103
SER A 106
VAL A 126
ILE A 150
THR A 154
 ERY  A 195 (-4.4A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.9A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
ERY  A 195 ( 4.1A)
 0.44A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		5 / 5 ASN A 102
ARG A 122
ASN A 123
HIS A 147
ALA A 151
 ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
 0.00A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		12 / 12 THR A  17
LEU A  20
GLY A  62
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
ILE A 105
SER A 106
VAL A 126
ILE A 150
 ERY  A 195 (-4.4A)
None
ERY  A 195 ( 4.1A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 ( 4.3A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
 0.50A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		7 / 7 LYS A  21
ASN A 102
TYR A 103
ARG A 122
ASN A 123
HIS A 147
ALA A 151
 CL  A 198 ( 4.7A)
ERY  A 195 (-3.9A)
ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
 0.53A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		5 / 12 HIS A 147
MET A  93
SER A  92
LEU A  70
PHE A  85
 ERY  A 195 (-4.2A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.6A)
None
None
 1.14A 4qdcA-3frqA:
undetectable		 4qdcA-3frqA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		4 / 4 ARG A  51
GLN A 111
PHE A  28
LEU A 110
 None
 1.36A 5uhgC-3frqA:
0.7		 5uhgC-3frqA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		4 / 7 ARG A 133
ILE A 130
LEU A 177
PHE A 181
 None
 1.03A 5vc0A-3frqA:
undetectable		 5vc0A-3frqA:
17.50