SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fs1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 6 SER A 158
THR A 157
ASN A 238
LEU A 236
 None
None
None
MYR  A 500 (-3.7A)
 1.35A 1mxdA-3fs1A:
undetectable		 1mxdA-3fs1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 SER A 256
VAL A 178
ILE A 175
ILE A 349
ILE A 346
 MYR  A 500 ( 4.1A)
None
None
None
MYR  A 500 (-4.7A)
 0.97A 1qhsA-3fs1A:
undetectable		 1qhsA-3fs1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 SER A 256
VAL A 178
ILE A 175
ILE A 349
ILE A 346
 MYR  A 500 ( 4.1A)
None
None
None
MYR  A 500 (-4.7A)
 0.99A 1qhyA-3fs1A:
undetectable		 1qhyA-3fs1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 210
ILE A 196
SER A 309
SER A 139
ILE A 299
 None
 1.34A 1xotA-3fs1A:
undetectable		 1xotA-3fs1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 211
ALA A 209
LEU A 293
LEU A 202
PHE A 285
 None
 1.10A 2w9hA-3fs1A:
undetectable		 2w9hA-3fs1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 8 LEU A 332
ILE A 284
HIS A 214
GLY A 216
 None
 0.91A 3b9lA-3fs1A:
undetectable		 3b9lA-3fs1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.25A 3bexC-3fs1A:
undetectable
3bexD-3fs1A:
undetectable		 3bexC-3fs1A:
20.51
3bexD-3fs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 THR A 224
LEU A 263
THR A 334
ARG A 258
ILE A 338
 None
 1.25A 3bexE-3fs1A:
undetectable
3bexF-3fs1A:
undetectable		 3bexE-3fs1A:
20.51
3bexF-3fs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.27A 3bf1A-3fs1A:
undetectable
3bf1B-3fs1A:
undetectable		 3bf1A-3fs1A:
20.51
3bf1B-3fs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.29A 3bf1C-3fs1A:
undetectable
3bf1D-3fs1A:
undetectable		 3bf1C-3fs1A:
20.51
3bf1D-3fs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 THR A 224
LEU A 263
THR A 334
ARG A 258
ILE A 338
 None
 1.25A 3bf1C-3fs1A:
undetectable
3bf1D-3fs1A:
undetectable		 3bf1C-3fs1A:
20.51
3bf1D-3fs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.26A 3bf1E-3fs1A:
undetectable
3bf1F-3fs1A:
undetectable		 3bf1E-3fs1A:
20.51
3bf1F-3fs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 THR A 224
LEU A 263
THR A 334
ARG A 258
ILE A 338
 None
 1.28A 3bf1E-3fs1A:
undetectable
3bf1F-3fs1A:
undetectable		 3bf1E-3fs1A:
20.51
3bf1F-3fs1A:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 CYH A 179
GLN A 185
LEU A 219
ARG A 226
LEU A 236
 None
None
MYR  A 500 ( 4.0A)
MYR  A 500 (-2.8A)
MYR  A 500 (-3.7A)
 0.83A 3fc6C-3fs1A:
23.8		 3fc6C-3fs1A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		6 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 338
ILE A 259
 None
None
MYR  A 500 (-3.5A)
None
None
None
 0.97A 3s54A-3fs1A:
undetectable		 3s54A-3fs1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		6 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 338
ILE A 259
 None
None
MYR  A 500 (-3.5A)
None
None
None
 1.06A 3s54B-3fs1A:
undetectable		 3s54B-3fs1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 7 LEU A 263
ALA A 223
VAL A 178
ILE A 259
 None
MYR  A 500 (-3.5A)
None
None
 0.87A 3wsjB-3fs1A:
undetectable		 3wsjB-3fs1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 324
LEU A 328
GLU A 327
 None
 0.76A 4l3gF-3fs1A:
undetectable		 4l3gF-3fs1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 7 ALA A 173
LEU A 236
LEU A 235
ILE A 172
 None
MYR  A 500 (-3.7A)
None
None
 0.74A 4ubsA-3fs1A:
undetectable		 4ubsA-3fs1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 219
GLU A 184
LEU A 186
LEU A 361
LEU A 365
 MYR  A 500 ( 4.0A)
None
None
None
None
 1.10A 4wg0G-3fs1A:
undetectable
4wg0H-3fs1A:
undetectable
4wg0I-3fs1A:
undetectable		 4wg0G-3fs1A:
11.58
4wg0H-3fs1A:
11.58
4wg0I-3fs1A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 219
GLU A 184
LEU A 186
LEU A 361
LEU A 365
 MYR  A 500 ( 4.0A)
None
None
None
None
 1.04A 4wg0K-3fs1A:
undetectable
4wg0L-3fs1A:
undetectable
4wg0M-3fs1A:
undetectable		 4wg0K-3fs1A:
11.58
4wg0L-3fs1A:
11.58
4wg0M-3fs1A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		6 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 338
ILE A 259
 None
None
MYR  A 500 (-3.5A)
None
None
None
 1.03A 5e5jA-3fs1A:
undetectable		 5e5jA-3fs1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 9 LEU A 211
ILE A 196
GLU A 201
PHE A 199
GLU A 191
 None
 1.18A 5igzA-3fs1A:
undetectable		 5igzA-3fs1A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		3 / 3 LEU A 186
LEU A 189
TRP A 192
 None
 0.80A 5nwuA-3fs1A:
undetectable		 5nwuA-3fs1A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 259
 None
None
MYR  A 500 (-3.5A)
None
None
 0.87A 5t8hA-3fs1A:
undetectable		 5t8hA-3fs1A:
20.35