SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ALA A 195
VAL A 178
TRP A 239
 None
 0.96A 1av2A-3fscA:
undetectable
1av2B-3fscA:
undetectable		 1av2A-3fscA:
13.89
1av2B-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ALA A 195
VAL A 178
TRP A 239
 None
 0.88A 1gmkA-3fscA:
undetectable
1gmkB-3fscA:
undetectable		 1gmkA-3fscA:
13.89
1gmkB-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ALA A 195
VAL A 178
TRP A 239
 None
 0.95A 1gmkC-3fscA:
undetectable
1gmkD-3fscA:
undetectable		 1gmkC-3fscA:
13.89
1gmkD-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 GLY A  32
CYH A  33
PHE A  46
THR A  81
 None
 0.88A 1oc3A-3fscA:
undetectable		 1oc3A-3fscA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 PRO A 161
ILE A 173
GLY A 170
ILE A 189
VAL A 125
 None
 1.07A 1sg9A-3fscA:
undetectable		 1sg9A-3fscA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 PRO A 161
ILE A 173
GLY A 170
ILE A 189
VAL A 125
 None
 1.03A 1sg9B-3fscA:
undetectable		 1sg9B-3fscA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ALA A 195
VAL A 178
TRP A 239
 None
 0.94A 1w5uA-3fscA:
undetectable
1w5uB-3fscA:
undetectable		 1w5uA-3fscA:
13.89
1w5uB-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 239
ALA A 195
VAL A 178
 None
 0.98A 1w5uA-3fscA:
undetectable
1w5uB-3fscA:
undetectable		 1w5uA-3fscA:
13.89
1w5uB-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 239
ALA A 195
VAL A 178
 None
 0.98A 2izqC-3fscA:
undetectable
2izqD-3fscA:
undetectable		 2izqC-3fscA:
13.89
2izqD-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ILE A 144
SER A 143
ILE A 145
ASN A 192
VAL A 131
 None
 1.00A 2nnhA-3fscA:
undetectable		 2nnhA-3fscA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 239
VAL A 197
TRP A 150
 None
 1.20A 2xdcC-3fscA:
undetectable
2xdcD-3fscA:
undetectable		 2xdcC-3fscA:
13.89
2xdcD-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 239
VAL A 197
TRP A 150
 None
 1.20A 2y5mE-3fscA:
undetectable
2y5mF-3fscA:
undetectable		 2y5mE-3fscA:
13.89
2y5mF-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ILE A 121
ILE A 103
ILE A 115
PHE A  95
VAL A 149
 None
 0.91A 2ygoA-3fscA:
undetectable		 2ygoA-3fscA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 ILE A 191
ARG A 182
ILE A 179
THR A 211
 None
 1.17A 3ia4C-3fscA:
undetectable		 3ia4C-3fscA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 TRP A 239
ALA A 195
VAL A 178
 None
 0.98A 3l8lC-3fscA:
undetectable
3l8lD-3fscA:
undetectable		 3l8lC-3fscA:
13.89
3l8lD-3fscA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 10 PHE A  95
SER A 119
LEU A 151
VAL A 149
VAL A 139
 None
 1.37A 3u9fE-3fscA:
undetectable		 3u9fE-3fscA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		6 / 12 ALA A 180
ILE A 221
GLY A 215
ALA A 201
ALA A 195
VAL A 212
 COA  A 300 (-3.3A)
None
COA  A 300 ( 4.2A)
None
None
None
 1.46A 4nkxB-3fscA:
undetectable		 4nkxB-3fscA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 LYS A  68
ASP A  88
ILE A  65
 None
 0.85A 5kc4E-3fscA:
undetectable		 5kc4E-3fscA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 VAL A 139
ILE A 145
GLY A 128
LEU A 157
ILE A 121
 None
 1.04A 6dh6B-3fscA:
undetectable		 6dh6B-3fscA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3fsc QDTC
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ILE A 121
SER A 143
ASN A 136
ILE A 145
LEU A 151
 None
 1.11A 6dwnC-3fscA:
undetectable		 6dwnC-3fscA:
16.13