SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fsg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		6 / 12 ILE A  83
ALA A  85
PHE A  88
ILE A 103
LEU A  90
ILE A  79
 None
 1.37A 1drbB-3fsgA:
undetectable		 1drbB-3fsgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		4 / 8 ALA A  78
GLU A  81
LEU A   5
HIS A  25
 None
 0.76A 1ereE-3fsgA:
undetectable		 1ereE-3fsgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		4 / 8 ALA A  78
GLU A  81
LEU A   5
HIS A  25
 None
 0.77A 1ereF-3fsgA:
undetectable		 1ereF-3fsgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.42A 1h1dA-3fsgA:
3.0		 1h1dA-3fsgA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		3 / 3 ASP A 259
LEU A 262
HIS A  93
 None
 0.67A 1qknA-3fsgA:
undetectable		 1qknA-3fsgA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 ILE A  83
THR A   6
ILE A  10
LEU A  52
ILE A  82
 None
 1.03A 1rd7B-3fsgA:
undetectable		 1rd7B-3fsgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.47A 1vidA-3fsgA:
3.4		 1vidA-3fsgA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.39A 2cl5B-3fsgA:
2.7		 2cl5B-3fsgA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 SER A  94
TYR A  95
VAL A 120
VAL A 219
HIS A 244
 SO4  A 406 (-3.6A)
None
SO4  A 406 (-4.7A)
None
None
 0.70A 2rguA-3fsgA:
8.8		 2rguA-3fsgA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 11 SER A  94
TYR A  95
VAL A 120
VAL A 219
HIS A 244
 SO4  A 406 (-3.6A)
None
SO4  A 406 (-4.7A)
None
None
 0.73A 2rguB-3fsgA:
15.4		 2rguB-3fsgA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.40A 2zvjA-3fsgA:
2.8		 2zvjA-3fsgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 SER A  94
TYR A  95
VAL A 120
VAL A 219
HIS A 244
 SO4  A 406 (-3.6A)
None
SO4  A 406 (-4.7A)
None
None
 0.76A 3bjmA-3fsgA:
8.4		 3bjmA-3fsgA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.36A 3bwmA-3fsgA:
2.9		 3bwmA-3fsgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 LEU A 187
LEU A  75
LEU A  99
GLY A  96
HIS A  25
 None
 1.34A 3g1uA-3fsgA:
5.5		 3g1uA-3fsgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 LEU A 187
LEU A  75
LEU A  99
GLY A  96
HIS A  25
 None
 1.36A 3g1uB-3fsgA:
5.6		 3g1uB-3fsgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		3 / 3 HIS A 257
PHE A  38
PHE A  37
 None
 0.78A 3lk0D-3fsgA:
undetectable		 3lk0D-3fsgA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 THR A  74
LEU A  52
LEU A  24
GLY A  96
PHE A 193
 None
 1.26A 3n58C-3fsgA:
undetectable		 3n58C-3fsgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		3 / 3 ASP A 216
GLU A 223
SER A 155
 None
 0.83A 3p2kA-3fsgA:
2.9		 3p2kA-3fsgA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 SER A  94
TYR A  95
VAL A 120
VAL A 219
HIS A 244
 SO4  A 406 (-3.6A)
None
SO4  A 406 (-4.7A)
None
None
 0.78A 3w2tA-3fsgA:
15.1		 3w2tA-3fsgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 SER A  94
TYR A  95
VAL A 120
VAL A 219
HIS A 244
 SO4  A 406 (-3.6A)
None
SO4  A 406 (-4.7A)
None
None
 0.78A 3w2tB-3fsgA:
11.5		 3w2tB-3fsgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 ILE A  83
THR A   6
ILE A  10
LEU A  52
ILE A  82
 None
 1.01A 4i13A-3fsgA:
undetectable		 4i13A-3fsgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		4 / 6 GLY A  58
ASP A  53
GLY A 175
SER A  94
 None
None
None
SO4  A 406 (-3.6A)
 1.03A 4z53A-3fsgA:
2.5
4z53B-3fsgA:
2.6		 4z53A-3fsgA:
16.84
4z53B-3fsgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		3 / 3 LYS A 127
ARG A 128
HIS A 125
 None
SO4  A 406 (-2.8A)
SO4  A 406 (-3.6A)
 1.18A 4zbrA-3fsgA:
undetectable		 4zbrA-3fsgA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		6 / 12 ILE A  83
ALA A  85
PHE A  88
ILE A 103
LEU A  90
ILE A  79
 None
 1.39A 5eajA-3fsgA:
2.3		 5eajA-3fsgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 LEU A  75
SER A  68
PRO A  55
SER A  33
GLY A 175
 None
 1.06A 5f9zB-3fsgA:
2.8		 5f9zB-3fsgA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.43A 5fhrA-3fsgA:
2.8		 5fhrA-3fsgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.36A 5fhrB-3fsgA:
2.8		 5fhrB-3fsgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		6 / 12 ILE A  83
ALA A  85
PHE A  88
ILE A 103
LEU A  90
ILE A  79
 None
 1.38A 5ujxA-3fsgA:
2.3		 5ujxA-3fsgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		4 / 7 ARG A  49
TYR A  51
GLU A  39
LEU A 262
 None
CSO  A  35 ( 3.6A)
None
None
 1.20A 5umwB-3fsgA:
undetectable
5umwE-3fsgA:
undetectable		 5umwB-3fsgA:
13.66
5umwE-3fsgA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		6 / 12 ILE A  83
ALA A  85
PHE A  88
ILE A 103
LEU A  90
ILE A  79
 None
 1.38A 5z6jA-3fsgA:
undetectable		 5z6jA-3fsgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		6 / 12 ILE A  83
ALA A  85
PHE A  88
ILE A 103
LEU A  90
ILE A  79
 None
 1.37A 5z6kA-3fsgA:
undetectable		 5z6kA-3fsgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 SER A  94
TYR A  95
VAL A 120
VAL A 219
HIS A 244
 SO4  A 406 (-3.6A)
None
SO4  A 406 (-4.7A)
None
None
 0.77A 6b1eB-3fsgA:
15.5		 6b1eB-3fsgA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		5 / 12 ILE A 210
PHE A 208
PHE A 261
ALA A 100
ILE A 121
 None
 1.10A 6dwnD-3fsgA:
undetectable		 6dwnD-3fsgA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		3 / 3 TRP A 165
GLU A 145
GLU A 148
 None
 1.01A 6fhwA-3fsgA:
undetectable		 6fhwA-3fsgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		4 / 4 ASP A 152
ILE A 173
PRO A 174
LEU A 176
 None
 1.20A 6mkeB-3fsgA:
undetectable		 6mkeB-3fsgA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE
(Oenococcus
oeni) 		4 / 4 ASP A 152
ILE A 173
PRO A 174
LEU A 176
 None
 1.17A 6mkeA-3fsgA:
undetectable		 6mkeA-3fsgA:
14.50