SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fsn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 12 GLY A  46
PRO A  47
HIS A  59
PHE A  50
PHE A 526
 None
 1.41A 1fdsA-3fsnA:
undetectable		 1fdsA-3fsnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 11 SER A 488
GLU A 469
GLY A 436
LEU A 447
PRO A 444
 None
 1.35A 1i9jH-3fsnA:
undetectable
1i9jL-3fsnA:
undetectable		 1i9jH-3fsnA:
16.14
1i9jL-3fsnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 12 LEU A 160
LEU A  66
LEU A  22
ARG A  85
TYR A  89
 None
 1.15A 1kt5A-3fsnA:
undetectable		 1kt5A-3fsnA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 PHE A  61
PHE A 526
PHE A 418
 None
 0.69A 2od9A-3fsnA:
undetectable		 2od9A-3fsnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 PHE A  61
PHE A 526
PHE A 418
 None
 0.69A 2qqgA-3fsnA:
undetectable		 2qqgA-3fsnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 4 HIS A 313
HIS A 180
HIS A 241
HIS A 527
 FE2  A 534 (-3.4A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
FE2  A 534 (-3.3A)
 1.12A 2wkoA-3fsnA:
undetectable		 2wkoA-3fsnA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 7 GLU A 462
TYR A 501
ARG A 515
GLU A 512
 None
 1.14A 2zt7A-3fsnA:
undetectable		 2zt7A-3fsnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 5 LYS A 455
TYR A 426
ASP A 327
GLU A 406
 None
 1.45A 3dh0B-3fsnA:
undetectable		 3dh0B-3fsnA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 5 ILE A 100
THR A 147
PHE A 103
TYR A 275
 None
 1.26A 3em0A-3fsnA:
2.2		 3em0A-3fsnA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 12 GLY A  46
CYH A  45
HIS A 180
VAL A 155
ILE A  84
 None
None
FE2  A 534 (-3.4A)
None
None
 1.25A 3g9eA-3fsnA:
undetectable		 3g9eA-3fsnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 7 TYR A 137
LEU A 529
ASN A 135
THR A 153
 None
 0.90A 3lm8A-3fsnA:
undetectable
3lm8C-3fsnA:
undetectable		 3lm8A-3fsnA:
17.42
3lm8C-3fsnA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 6 GLU A 141
ASP A 142
TYR A 143
LYS A 154
 None
 1.27A 3pocB-3fsnA:
undetectable		 3pocB-3fsnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 HIS A 527
HIS A 180
HIS A 313
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.4A)
 0.58A 3qpkA-3fsnA:
undetectable		 3qpkA-3fsnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 HIS A 527
HIS A 180
HIS A 313
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.4A)
 0.59A 3qpkB-3fsnA:
undetectable		 3qpkB-3fsnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 HIS A 313
GLU A 469
ASN A 135
 FE2  A 534 (-3.4A)
None
None
 1.03A 4bupB-3fsnA:
undetectable		 4bupB-3fsnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 10 PHE A 526
ALA A 132
LEU A 133
GLY A  46
ALA A 273
 None
 1.43A 4fe1A-3fsnA:
undetectable
4fe1J-3fsnA:
undetectable		 4fe1A-3fsnA:
20.08
4fe1J-3fsnA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 12 LEU A 383
ILE A 401
LEU A 395
TYR A 304
ILE A 300
 None
 0.98A 4odrA-3fsnA:
undetectable
4odrB-3fsnA:
undetectable		 4odrA-3fsnA:
12.84
4odrB-3fsnA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 11 LEU A 383
ILE A 401
LEU A 395
TYR A 304
ILE A 300
 None
 0.97A 4odrA-3fsnA:
undetectable
4odrB-3fsnA:
undetectable		 4odrA-3fsnA:
12.84
4odrB-3fsnA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 6 THR A 147
THR A 149
THR A 105
LEU A 133
 None
 1.03A 4pgfA-3fsnA:
undetectable		 4pgfA-3fsnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 5 LEU A 439
GLU A 469
LEU A  15
HIS A   7
 None
 1.32A 4xi3B-3fsnA:
undetectable		 4xi3B-3fsnA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 7 GLU A 254
ILE A 202
LEU A 265
ILE A 259
 None
 0.98A 4xumA-3fsnA:
undetectable		 4xumA-3fsnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 7 ASN A 156
TYR A 144
TYR A 137
LEU A 529
 None
 1.05A 4yv5B-3fsnA:
undetectable		 4yv5B-3fsnA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 8 TYR A 190
LYS A 208
THR A 246
ARG A 296
 None
None
None
PG4  A 535 ( 3.3A)
 1.09A 5jhdE-3fsnA:
undetectable
5jhdG-3fsnA:
undetectable		 5jhdE-3fsnA:
19.11
5jhdG-3fsnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 HIS A 527
HIS A 180
HIS A 313
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.4A)
 0.54A 5migA-3fsnA:
undetectable		 5migA-3fsnA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		5 / 10 HIS A 527
HIS A 180
TYR A 239
THR A 149
HIS A 241
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
None
None
FE2  A 534 (-3.3A)
 1.13A 5nzwA-3fsnA:
undetectable		 5nzwA-3fsnA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 5 HIS A 313
HIS A 527
HIS A 180
HIS A 241
 FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
 1.07A 5zrdB-3fsnA:
undetectable		 5zrdB-3fsnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 4 HIS A 313
HIS A 527
HIS A 180
HIS A 241
 FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
 1.05A 5zrdC-3fsnA:
undetectable		 5zrdC-3fsnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 4 HIS A 313
HIS A 527
HIS A 180
HIS A 241
 FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
 1.05A 5zrdD-3fsnA:
undetectable		 5zrdD-3fsnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 7 ILE A 225
VAL A 174
ALA A 177
THR A 178
 None
 0.77A 6cduC-3fsnA:
undetectable
6cduD-3fsnA:
undetectable		 6cduC-3fsnA:
19.67
6cduD-3fsnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 8 ILE A 225
VAL A 174
ALA A 177
THR A 178
 None
 0.81A 6cduD-3fsnA:
undetectable
6cduE-3fsnA:
undetectable		 6cduD-3fsnA:
19.67
6cduE-3fsnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		4 / 7 ALA A 177
THR A 178
ILE A 225
VAL A 174
 None
 0.80A 6cduF-3fsnA:
undetectable
6cduJ-3fsnA:
undetectable		 6cduF-3fsnA:
19.67
6cduJ-3fsnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 TYR A 338
HIS A  59
PHE A 103
 None
 0.85A 6esmA-3fsnA:
undetectable		 6esmA-3fsnA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN
(Bos
taurus) 		3 / 3 ARG A 367
LEU A 408
PHE A 409
 None
 0.80A 6nknP-3fsnA:
undetectable		 6nknP-3fsnA:
16.98