SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fsr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 ASP A  89
ASP A 128
LYS A 111
 None
 1.04A 1lqtB-3fsrA:
3.5		 1lqtB-3fsrA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 ASP A  89
ASP A 128
LYS A 111
 None
 1.07A 1lquB-3fsrA:
3.4		 1lquB-3fsrA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 158
GLY A 182
ILE A 164
ALA A 186
SER A 263
 None
 1.02A 1ri4A-3fsrA:
7.7		 1ri4A-3fsrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 4 THR A  43
GLY A 118
ASP A 117
ALA A   5
 None
 1.19A 1sg9A-3fsrA:
5.9		 1sg9A-3fsrA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.65A 1wmqA-3fsrA:
undetectable		 1wmqA-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.67A 1wmqB-3fsrA:
undetectable		 1wmqB-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.66A 1wpuA-3fsrA:
undetectable		 1wpuA-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.66A 1wpuB-3fsrA:
undetectable		 1wpuB-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.63A 1wrqA-3fsrA:
undetectable		 1wrqA-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.63A 1wrqB-3fsrA:
undetectable		 1wrqB-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ALA A 191
ILE A 194
ILE A 164
PHE A 156
ILE A 265
 None
 1.01A 1xozA-3fsrA:
undetectable		 1xozA-3fsrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.82A 2qmmA-3fsrA:
2.4		 2qmmA-3fsrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 11 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.87A 2qmmA-3fsrA:
undetectable
2qmmB-3fsrA:
2.6		 2qmmA-3fsrA:
20.22
2qmmB-3fsrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 4 GLY A 176
GLY A 174
GLY A 243
GLY A 179
 None
 0.65A 3bogC-3fsrA:
undetectable		 3bogC-3fsrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 182
GLY A 158
ALA A 177
GLY A 176
ILE A 265
 None
 0.95A 3ku1A-3fsrA:
5.7		 3ku1A-3fsrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 8 ILE A 164
ALA A 184
VAL A 172
VAL A 170
 None
 0.84A 3me6B-3fsrA:
undetectable		 3me6B-3fsrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 9 GLY A 211
ALA A 212
ASP A 214
GLY A 192
ILE A 240
 None
 0.90A 3s53A-3fsrA:
undetectable		 3s53A-3fsrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
ILE A 240
 None
 0.86A 3s54A-3fsrA:
undetectable		 3s54A-3fsrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
ILE A 240
 None
 0.85A 3s54B-3fsrA:
undetectable		 3s54B-3fsrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 GLY A 211
ALA A 212
ASP A 214
GLY A 192
ILE A 240
 None
 0.85A 3s56A-3fsrA:
undetectable		 3s56A-3fsrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 5 ILE A 306
ALA A 145
HIS A 135
ARG A  80
 None
 0.97A 4ac9B-3fsrA:
undetectable
4ac9C-3fsrA:
2.9		 4ac9B-3fsrA:
22.72
4ac9C-3fsrA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 5 ILE A 306
ALA A 145
HIS A 135
ARG A  80
 None
 0.97A 4acaB-3fsrA:
2.5
4acaC-3fsrA:
2.6		 4acaB-3fsrA:
22.72
4acaC-3fsrA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 6 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 ZN  A 354 (-4.3A)
None
None
None
None
 1.26A 4dxuA-3fsrA:
undetectable		 4dxuA-3fsrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 GLY A 260
VAL A 256
PRO A 258
GLY A 282
 ZN  A 354 (-4.3A)
None
None
None
 0.74A 4forA-3fsrA:
undetectable		 4forA-3fsrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 LYS A 340
GLY A 176
ILE A 240
GLY A 155
ASN A 266
 None
 1.16A 4obwD-3fsrA:
7.0		 4obwD-3fsrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 THR A 248
TYR A 218
GLY A 174
GLY A 243
 None
 0.89A 4rdxA-3fsrA:
2.0		 4rdxA-3fsrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ARG A 301
LEU A 305
VAL A 314
VAL A 178
GLY A 158
 None
 1.18A 5i8fA-3fsrA:
undetectable		 5i8fA-3fsrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 GLY A 244
GLY A 245
GLN A 251
 None
 0.30A 5imsA-3fsrA:
2.2		 5imsA-3fsrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		3 / 3 GLY A  23
ASP A  26
ASN A 132
 None
 0.48A 5jglA-3fsrA:
8.4		 5jglA-3fsrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		4 / 7 VAL A 348
ILE A 350
VAL A  62
ALA A  33
 None
 0.74A 5ospA-3fsrA:
undetectable		 5ospA-3fsrA:
23.12