SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 GLY A   9
HIS A  90
THR A  39
THR A  70
ALA A  13
 None
 1.34A 1gtnO-3fsxA:
undetectable
1gtnP-3fsxA:
undetectable		 1gtnO-3fsxA:
14.29
1gtnP-3fsxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 202
GLY A 215
VAL A 198
ALA A 258
LEU A 288
 None
 1.02A 1kiaC-3fsxA:
undetectable		 1kiaC-3fsxA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 202
GLY A 215
VAL A 198
ALA A 258
LEU A 288
 None
 1.02A 1nbhB-3fsxA:
undetectable		 1nbhB-3fsxA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  29
GLY A   9
THR A  24
GLY A  11
 None
 0.83A 1usqA-3fsxA:
undetectable		 1usqA-3fsxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  29
GLY A   9
THR A  24
GLY A  11
 None
 0.83A 1usqF-3fsxA:
undetectable		 1usqF-3fsxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  29
GLY A   9
THR A  24
GLY A  11
 None
 0.86A 2jklA-3fsxA:
undetectable		 2jklA-3fsxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  29
GLY A   9
THR A  24
GLY A  11
 None
 0.88A 2jklC-3fsxA:
undetectable		 2jklC-3fsxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 4 ALA A  28
HIS A  94
HIS A  90
PRO A  29
 None
MPD  A 340 (-4.7A)
None
None
 1.44A 3mbgA-3fsxA:
undetectable		 3mbgA-3fsxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 4 ALA A  28
HIS A  94
HIS A  90
PRO A  29
 None
MPD  A 340 (-4.7A)
None
None
 1.42A 3mbgC-3fsxA:
undetectable		 3mbgC-3fsxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		6 / 11 ARG A  95
ALA A 165
ASP A 166
ASP A 164
VAL A 160
ILE A 162
 MPD  A 340 (-3.9A)
None
NA  A 334 ( 3.7A)
NA  A 334 (-3.3A)
None
None
 1.46A 3ndxB-3fsxA:
undetectable		 3ndxB-3fsxA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  26
THR A  39
ALA A   7
ALA A   8
 None
 1.20A 3ns1C-3fsxA:
undetectable		 3ns1C-3fsxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 247
GLY A 245
SER A 219
MET A 221
LEU A 260
 None
None
ACY  A 331 (-2.6A)
None
None
 1.18A 3ou7A-3fsxA:
undetectable		 3ou7A-3fsxA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 247
GLY A 245
SER A 219
MET A 221
LEU A 260
 None
None
ACY  A 331 (-2.6A)
None
None
 1.19A 3ou7D-3fsxA:
undetectable		 3ou7D-3fsxA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 9 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.34A 3p4wA-3fsxA:
undetectable		 3p4wA-3fsxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 101
VAL A  97
PRO A  99
GLY A 171
 None
 0.75A 4dxuA-3fsxA:
undetectable		 4dxuA-3fsxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 248
GLY A 247
ALA A 278
LEU A 281
VAL A 276
 None
 1.29A 5hw4B-3fsxA:
undetectable		 5hw4B-3fsxA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 9 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.33A 5mvnC-3fsxA:
undetectable		 5mvnC-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.34A 5mvnD-3fsxA:
undetectable		 5mvnD-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.49A 5mzrA-3fsxA:
undetectable		 5mzrA-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.47A 5mzrC-3fsxA:
undetectable		 5mzrC-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 256
LEU A 240
VAL A 262
GLY A 247
ILE A 248
 None
 1.04A 5vopA-3fsxA:
undetectable		 5vopA-3fsxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 155
ILE A 162
GLY A 211
ALA A 175
 None
 0.89A 6hd6B-3fsxA:
undetectable		 6hd6B-3fsxA:
13.21