SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ftb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.79A 11gsA-3ftbA:
undetectable		 11gsA-3ftbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.79A 11gsB-3ftbA:
undetectable		 11gsB-3ftbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 LEU A 316
LEU A 304
CYH A 326
VAL A 300
ILE A 323
 None
 0.95A 1ee2A-3ftbA:
4.8		 1ee2A-3ftbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 LEU A 316
LEU A 304
CYH A 326
VAL A 300
ILE A 323
 None
 0.99A 1ee2B-3ftbA:
4.6		 1ee2B-3ftbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 ASP A 183
PHE A 208
ASN A 114
 None
 0.70A 1sg9B-3ftbA:
4.4		 1sg9B-3ftbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 TYR A 111
ILE A  95
ILE A 181
ASP A 183
 None
 0.92A 1upfB-3ftbA:
3.4		 1upfB-3ftbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A  83
GLU A  89
GLY A  86
ALA A  87
ALA A 185
 None
None
PO4  A 362 (-3.4A)
PO4  A 362 (-3.2A)
None
 1.23A 2br4B-3ftbA:
3.4		 2br4B-3ftbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.81A 2gssA-3ftbA:
undetectable		 2gssA-3ftbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.80A 2gssB-3ftbA:
undetectable		 2gssB-3ftbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 ILE A  95
ILE A  91
ILE A 101
ALA A 185
 None
 0.54A 2nniA-3ftbA:
undetectable		 2nniA-3ftbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 PRO A 153
ILE A 150
ASN A 157
LEU A 127
 None
 1.15A 2wekB-3ftbA:
4.8		 2wekB-3ftbA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 PHE A 216
PHE A 299
ASN A 152
GLY A 151
LEU A 160
 None
 1.34A 3aodC-3ftbA:
undetectable		 3aodC-3ftbA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.87A 3axzA-3ftbA:
undetectable		 3axzA-3ftbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.85A 3gssA-3ftbA:
undetectable		 3gssA-3ftbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.82A 3gssB-3ftbA:
undetectable		 3gssB-3ftbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A 173
VAL A 148
ILE A 138
ILE A 167
ILE A 180
 None
 0.99A 3k4vC-3ftbA:
undetectable		 3k4vC-3ftbA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 LEU A  45
PHE A  44
ILE A  40
PHE A 216
 None
 0.88A 3ko0S-3ftbA:
undetectable		 3ko0S-3ftbA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 ASN A  47
ASN A  54
GLU A 252
 None
 0.89A 3kpdC-3ftbA:
undetectable		 3kpdC-3ftbA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 PHE A 186
ILE A  91
TYR A 111
GLY A 151
 None
 0.89A 3n9jA-3ftbA:
undetectable		 3n9jA-3ftbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 TYR A  73
ASN A 152
GLU A 188
GLU A 184
 PO4  A 364 (-4.1A)
None
PO4  A 364 ( 4.4A)
None
 1.25A 4mi4A-3ftbA:
undetectable
4mi4C-3ftbA:
undetectable		 4mi4A-3ftbA:
20.61
4mi4C-3ftbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.90A 4yvgA-3ftbA:
undetectable		 4yvgA-3ftbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 151
ALA A 212
SER A  96
ILE A  95
PHE A  98
 None
PO4  A 362 ( 4.0A)
None
None
None
 1.23A 5igyA-3ftbA:
1.0		 5igyA-3ftbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 ILE A 150
LYS A 141
ILE A 142
VAL A 169
 None
 0.90A 5jmnA-3ftbA:
undetectable		 5jmnA-3ftbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 GLU A 200
LYS A 163
GLU A 184
PHE A 197
 None
 1.39A 5onlA-3ftbA:
1.6		 5onlA-3ftbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 GLY A 159
LEU A 160
HIS A 296
 None
 0.43A 5u63A-3ftbA:
2.3		 5u63A-3ftbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 GLY A 159
LEU A 160
HIS A 296
 None
 0.41A 5u63B-3ftbA:
2.1		 5u63B-3ftbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.95A 5wyqA-3ftbA:
undetectable		 5wyqA-3ftbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.92A 5wyqB-3ftbA:
undetectable		 5wyqB-3ftbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A 207
ALA A 173
VAL A 148
ILE A 182
ILE A 180
 None
 0.92A 6dh3A-3ftbA:
undetectable		 6dh3A-3ftbA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 GLU A 200
LYS A 163
GLU A 184
PHE A 197
 None
 1.39A 6hrjA-3ftbA:
undetectable		 6hrjA-3ftbA:
20.65