SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ftj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 6 LEU A 461
ALA A 377
LEU A 379
SER A 363
None
0.83A 1tz8C-3ftjA:
undetectable
1tz8D-3ftjA:
undetectable
1tz8C-3ftjA:
18.61
1tz8D-3ftjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 11 GLY A 317
SER A 491
ILE A 513
VAL A 483
ILE A 354
None
1.07A 2nnhA-3ftjA:
undetectable
2nnhA-3ftjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 12 THR A 361
GLY A 479
ASN A 325
GLY A 383
LEU A 340
None
1.12A 3eeyA-3ftjA:
undetectable
3eeyA-3ftjA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 12 THR A 361
GLY A 479
ASN A 325
GLY A 383
LEU A 340
None
1.13A 3eeyB-3ftjA:
undetectable
3eeyB-3ftjA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 5 TYR A 380
PRO A 464
THR A 401
THR A 482
None
1.42A 3q07A-3ftjA:
undetectable
3q07A-3ftjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 5 TYR A 380
PRO A 464
THR A 401
THR A 482
None
1.42A 3q07B-3ftjA:
undetectable
3q07B-3ftjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
3 / 3 ASP A 344
ARG A 477
LYS A 341
None
1.06A 3wipG-3ftjA:
undetectable
3wipG-3ftjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 6 LYS A 419
ILE A 422
VAL A 369
LYS A 431
None
1.02A 4em2A-3ftjA:
undetectable
4em2A-3ftjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 6 LEU A 461
ALA A 377
LEU A 379
SER A 363
None
0.94A 4i89A-3ftjA:
undetectable
4i89A-3ftjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 8 VAL A 412
VAL A 468
TYR A 380
TYR A 462
None
1.00A 4puoC-3ftjA:
3.5
4puoC-3ftjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 6 LEU A 461
ALA A 377
LEU A 379
SER A 363
None
0.90A 5bojA-3ftjA:
undetectable
5bojA-3ftjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 4 VAL A 413
GLY A 444
ARG A 398
VAL A 411
None
1.45A 5d4nA-3ftjA:
4.1
5d4nB-3ftjA:
4.3
5d4nA-3ftjA:
18.01
5d4nB-3ftjA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 6 LEU A 461
ALA A 377
LEU A 379
SER A 363
None
0.94A 5l4iA-3ftjA:
undetectable
5l4iA-3ftjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 12 ILE A 481
LEU A 502
SER A 334
HIS A 336
GLY A 479
None
1.17A 5l6eA-3ftjA:
undetectable
5l6eA-3ftjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
4 / 5 ASN A 490
VAL A 483
LEU A 348
SER A 497
None
1.20A 6a7pA-3ftjA:
undetectable
6a7pA-3ftjA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 10 PRO A 439
LEU A 379
SER A 463
ASP A 404
ILE A 472
None
1.43A 6dlzA-3ftjA:
undetectable
6dlzD-3ftjA:
undetectable
6dlzA-3ftjA:
18.91
6dlzD-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 10 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
None
1.42A 6dlzB-3ftjA:
undetectable
6dlzC-3ftjA:
undetectable
6dlzB-3ftjA:
18.91
6dlzC-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 11 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
None
1.45A 6dlzA-3ftjA:
undetectable
6dlzD-3ftjA:
undetectable
6dlzA-3ftjA:
18.91
6dlzD-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 9 PRO A 439
LEU A 379
SER A 463
ASP A 404
ILE A 472
None
1.41A 6dm0A-3ftjA:
undetectable
6dm0D-3ftjA:
undetectable
6dm0A-3ftjA:
18.91
6dm0D-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 9 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
None
1.41A 6dm0B-3ftjA:
undetectable
6dm0C-3ftjA:
undetectable
6dm0B-3ftjA:
18.91
6dm0C-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 10 PRO A 439
LEU A 379
SER A 463
ASP A 404
ILE A 472
None
1.42A 6dm1A-3ftjA:
undetectable
6dm1D-3ftjA:
undetectable
6dm1A-3ftjA:
18.91
6dm1D-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 10 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
None
1.43A 6dm1B-3ftjA:
undetectable
6dm1C-3ftjA:
undetectable
6dm1B-3ftjA:
18.91
6dm1C-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 11 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
None
1.45A 6dm1A-3ftjA:
undetectable
6dm1D-3ftjA:
undetectable
6dm1A-3ftjA:
18.91
6dm1D-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 9 PRO A 439
LEU A 379
SER A 463
ASP A 404
ILE A 472
None
1.43A 6dm2A-3ftjA:
undetectable
6dm2D-3ftjA:
undetectable
6dm2A-3ftjA:
18.91
6dm2D-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcom
itans)
5 / 9 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
None
1.43A 6dm2B-3ftjA:
undetectable
6dm2C-3ftjA:
undetectable
6dm2B-3ftjA:
18.91
6dm2C-3ftjA:
18.91