SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I9G_A_SAMA301_0 (HYPOTHETICAL PROTEIN RV2118C)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 54 GLY A 56 ALA A 59 LEU A 60 ASP A 99	None	0.50A	1i9gA-3futA: 13.4	1i9gA-3futA: 25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG2_A_ADNA500_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 54 GLY A 56 GLU A 75 LEU A 80 ASP A 99	None	0.57A	1jg2A-3futA: 9.5	1jg2A-3futA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG3_A_ADNA500_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 11	GLY A 54 GLY A 56 GLU A 75 LEU A 80 ASP A 99	None	0.52A	1jg3A-3futA: 9.2	1jg3A-3futA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG3_A_ADNA500_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 11	GLY A 54 GLY A 56 GLU A 75 LEU A 80 LEU A 118	None	0.75A	1jg3A-3futA: 9.2	1jg3A-3futA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG3_B_ADNB550_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 11	GLY A 54 GLY A 56 GLU A 75 LEU A 80 ASP A 99	None	0.51A	1jg3B-3futA: 8.9	1jg3B-3futA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG3_B_ADNB550_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 11	GLY A 54 GLY A 56 GLU A 75 LEU A 80 LEU A 118	None	0.76A	1jg3B-3futA: 8.9	1jg3B-3futA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG4_A_SAMA500_1 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 8	GLU A 52 GLY A 54 GLU A 75 LEU A 80 ASP A 99	None	0.65A	1jg4A-3futA: 9.5	1jg4A-3futA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JLB_A_NVPA999_1 (HIV-1 RT A-CHAIN)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 8	LEU A 227 GLY A 217 LEU A 211 TYR A 232	None	0.78A	1jlbA-3futA: undetectable	1jlbA-3futA: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 12	PHE A 29 GLU A 52 GLY A 54 GLY A 56 ASP A 77 LEU A 80 ASP A 99	None	0.74A	1qaoA-3futA: 21.3	1qaoA-3futA: 23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 12	PHE A 29 GLU A 52 GLY A 54 GLY A 56 ASP A 77 LEU A 80 PRO A 119	None	0.76A	1qaoA-3futA: 21.3	1qaoA-3futA: 23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	PHE A 29 GLU A 52 GLY A 56 LEU A 80 ASN A 117 PRO A 119	None	1.28A	1qaoA-3futA: 21.3	1qaoA-3futA: 23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	PHE A 29 GLU A 52 GLY A 56 LEU A 80 ILE A 74 ASN A 117	None	1.29A	1qaoA-3futA: 21.3	1qaoA-3futA: 23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ZQ9_A_SAMA4000_1 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	3 / 3	GLY A 54 GLU A 75 ASN A 117	None	0.65A	1zq9A-3futA: 24.8	1zq9A-3futA: 31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ZQ9_B_SAMB4001_0 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	GLY A 54 GLY A 56 ASP A 99 ASN A 117 LEU A 118 PHE A 184	None	1.13A	1zq9B-3futA: 24.1	1zq9B-3futA: 31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ZQ9_B_SAMB4001_0 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	GLY A 54 GLY A 56 LEU A 80 ASP A 99 ASN A 117 PHE A 184	None	0.63A	1zq9B-3futA: 24.1	1zq9B-3futA: 31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_B_SAMB301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 91 LEU A 65 GLU A 52 GLY A 58 ALA A 5	None	1.32A	2bm9B-3futA: 8.8	2bm9B-3futA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_A_1FLA2002_1 (SERUM ALBUMIN)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 10	PHE A 51 ALA A 43 LEU A 64 ALA A 67 VAL A 71	None	1.16A	2bxeA-3futA: undetectable	2bxeA-3futA: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_A_SAMA302_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 54 GLY A 56 LEU A 60 ASP A 77 LEU A 126	None	0.86A	2nxeA-3futA: 13.0	2nxeA-3futA: 27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_D_SAMD603_0 (HYPOTHETICAL PROTEIN)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 54 GLY A 56 ALA A 59 LEU A 60 ASP A 99	None	0.59A	2yvlD-3futA: 13.8	2yvlD-3futA: 24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9M_A_SALA1100_1 (SERUM ALBUMIN)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 4	LEU A 267 ARG A 242 LEU A 241 ALA A 235	None	1.17A	3b9mA-3futA: undetectable	3b9mA-3futA: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DXY_A_SAMA1_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 11	GLU A 52 GLY A 54 GLY A 56 ILE A 74 GLU A 75 ASP A 99 ALA A 100	None	0.76A	3dxyA-3futA: 9.3	3dxyA-3futA: 26.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FUU_A_ADNA0_1 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 12	VAL A 53 GLY A 54 GLY A 56 GLU A 75 ASP A 77 ASP A 99 ALA A 100	None	0.29A	3fuuA-3futA: 35.5	3fuuA-3futA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRV_A_ADNA300_1 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 11	GLY A 54 GLY A 56 GLU A 75 ASP A 77 LEU A 80 ASP A 99 ALA A 100	None	0.52A	3grvA-3futA: 24.5	3grvA-3futA: 29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRV_A_ADNA300_1 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 11	GLY A 54 GLY A 56 GLU A 75 LEU A 84 ASP A 99 ALA A 100	None	1.39A	3grvA-3futA: 24.5	3grvA-3futA: 29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRY_A_SAMA300_0 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	9 / 12	LEU A 30 GLU A 52 GLY A 54 GLY A 56 GLU A 75 ASP A 77 LEU A 80 ASP A 99 ALA A 100	None	0.69A	3gryA-3futA: 24.4	3gryA-3futA: 29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRY_A_SAMA300_0 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 12	LEU A 30 GLY A 54 GLY A 56 GLU A 75 LEU A 84 ASP A 99 ALA A 100	None	1.46A	3gryA-3futA: 24.4	3gryA-3futA: 29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRY_A_SAMA300_0 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	LEU A 30 GLY A 56 GLU A 75 ASP A 77 LEU A 80 PRO A 119	None	0.90A	3gryA-3futA: 24.4	3gryA-3futA: 29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRY_A_SAMA300_0 (DIMETHYLADENOSINE TRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	LEU A 60 GLY A 56 GLU A 75 ASP A 77 LEU A 80 ASP A 99	None	1.09A	3gryA-3futA: 24.4	3gryA-3futA: 29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 6	PHE A 209 ALA A 202 THR A 200 LEU A 257	None	0.99A	3t3zA-3futA: undetectable	3t3zA-3futA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 6	PHE A 209 ALA A 202 THR A 200 LEU A 257	None	0.98A	3t3zB-3futA: undetectable	3t3zB-3futA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_C_9PLC501_1 (CYTOCHROME P450 2E1)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 5	PHE A 209 ALA A 202 THR A 200 LEU A 257	None	1.00A	3t3zC-3futA: undetectable	3t3zC-3futA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 6	PHE A 209 ALA A 202 THR A 200 LEU A 257	None	0.96A	3t3zD-3futA: undetectable	3t3zD-3futA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_B_SAMB401_0 (MNMC2)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 54 GLY A 56 LEU A 57 LYS A 76 ALA A 100	None	0.77A	3vywB-3futA: 8.8	3vywB-3futA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_B_SAMB401_0 (MNMC2)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 54 GLY A 56 LEU A 57 LYS A 76 LEU A 118	None	0.97A	3vywB-3futA: 8.8	3vywB-3futA: 24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4GC9_A_SAMA401_1 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	3 / 3	GLU A 75 ASP A 77 ASP A 99	None	0.28A	4gc9A-3futA: 23.7	4gc9A-3futA: 31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1B_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 6	GLN A 144 PHE A 184 LEU A 179 PHE A 177	None	1.06A	5b1bC-3futA: undetectable 5b1bJ-3futA: undetectable	5b1bC-3futA: 22.11 5b1bJ-3futA: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CYM_A_T27A601_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 130 VAL A 108 TYR A 103 PHE A 51 LEU A 114	None	1.28A	5cymA-3futA: undetectable	5cymA-3futA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CYQ_A_T27A601_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 130 VAL A 108 TYR A 103 PHE A 51 LEU A 114	None	1.29A	5cyqA-3futA: undetectable	5cyqA-3futA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERG_B_SAMB401_1 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE CATALYTIC SUBUNIT TRM61)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 7	GLY A 54 GLY A 56 GLU A 75 ASP A 99	None	0.48A	5ergB-3futA: 12.4	5ergB-3futA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVS_A_ADNA401_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	4 / 7	GLY A 54 GLU A 75 LYS A 76 ASP A 99	None	0.85A	5mvsA-3futA: 10.9	5mvsA-3futA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5D_B_SAMB303_0 (METHYLTRANSFERASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 57 ALA A 59 GLU A 52 ILE A 74 GLU A 85	None	1.15A	5n5dB-3futA: 12.8	5n5dB-3futA: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA901_0 (MRNA CAPPING ENZYME P5)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 11	VAL A 53 GLY A 54 GLU A 75 LYS A 76 ASP A 99 ALA A 100 LEU A 126	None	0.96A	5x6yA-3futA: 8.1	5x6yA-3futA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA901_0 (MRNA CAPPING ENZYME P5)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 11	VAL A 53 GLY A 54 GLU A 75 LYS A 76 LEU A 118	None	1.04A	5x6yA-3futA: 8.1	5x6yA-3futA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_B_SAMB901_0 (MRNA CAPPING ENZYME P5)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 10	VAL A 53 GLY A 54 GLU A 75 LYS A 76 ASP A 99 ALA A 100 LEU A 126	None	0.95A	5x6yB-3futA: 3.3	5x6yB-3futA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_B_SAMB901_0 (MRNA CAPPING ENZYME P5)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 10	VAL A 53 GLY A 54 GLU A 75 LYS A 76 LEU A 118	None	0.93A	5x6yB-3futA: 3.3	5x6yB-3futA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_C_SAMC901_0 (MRNA CAPPING ENZYME P5)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 11	VAL A 53 GLY A 54 GLU A 75 LYS A 76 ASP A 99 ALA A 100 LEU A 126	None	0.88A	5x6yC-3futA: 4.3	5x6yC-3futA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_C_SAMC901_0 (MRNA CAPPING ENZYME P5)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 11	VAL A 53 GLY A 54 GLU A 75 LYS A 76 LEU A 118	None	0.90A	5x6yC-3futA: 4.3	5x6yC-3futA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ELI_A_T27A701_1 (REVERSE TRANSCRIPTASE)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 130 VAL A 108 TYR A 103 PHE A 51 LEU A 114	None	1.27A	6eliA-3futA: undetectable	6eliA-3futA: 14.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6IFT_A_SAMA301_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	7 / 12	LEU A 30 GLU A 52 GLY A 54 GLY A 56 ALA A 59 ASP A 77 LEU A 80	None	0.54A	6iftA-3futA: 29.0	6iftA-3futA: 37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6IFT_A_SAMA301_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	6 / 12	PHE A 29 LEU A 30 GLY A 54 GLY A 56 ASP A 77 LEU A 80	None	0.54A	6iftA-3futA: 29.0	6iftA-3futA: 37.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I9G_A_SAMA301_0","HYPOTHETICAL PROTEIN RV2118C","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;ALA A  59;LEU A  60;ASP A  99","None","0.50A","1i9gA-3futA:13.4","1i9gA-3futA:25.08"],["1JG2_A_ADNA500_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;GLU A  75;LEU A  80;ASP A  99","None","0.57A","1jg2A-3futA:9.5","1jg2A-3futA:22.92"],["1JG3_A_ADNA500_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;GLU A  75;LEU A  80;ASP A  99","None","0.52A","1jg3A-3futA:9.2","1jg3A-3futA:22.92"],["1JG3_A_ADNA500_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;GLU A  75;LEU A  80;LEU A 118","None","0.75A","1jg3A-3futA:9.2","1jg3A-3futA:22.92"],["1JG3_B_ADNB550_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;GLU A  75;LEU A  80;ASP A  99","None","0.51A","1jg3B-3futA:8.9","1jg3B-3futA:22.92"],["1JG3_B_ADNB550_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;GLU A  75;LEU A  80;LEU A 118","None","0.76A","1jg3B-3futA:8.9","1jg3B-3futA:22.92"],["1JG4_A_SAMA500_1","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLU A  52;GLY A  54;GLU A  75;LEU A  80;ASP A  99","None","0.65A","1jg4A-3futA:9.5","1jg4A-3futA:22.92"],["1JLB_A_NVPA999_1","HIV-1 RT A-CHAIN","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"LEU A 227;GLY A 217;LEU A 211;TYR A 232","None","0.78A","1jlbA-3futA:undetectable","1jlbA-3futA:20.07"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"PHE A  29;GLU A  52;GLY A  54;GLY A  56;ASP A  77;LEU A  80;ASP A  99","None","0.74A","1qaoA-3futA:21.3","1qaoA-3futA:23.93"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"PHE A  29;GLU A  52;GLY A  54;GLY A  56;ASP A  77;LEU A  80;PRO A 119","None","0.76A","1qaoA-3futA:21.3","1qaoA-3futA:23.93"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"PHE A  29;GLU A  52;GLY A  56;LEU A  80;ASN A 117;PRO A 119","None","1.28A","1qaoA-3futA:21.3","1qaoA-3futA:23.93"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"PHE A  29;GLU A  52;GLY A  56;LEU A  80;ILE A  74;ASN A 117","None","1.29A","1qaoA-3futA:21.3","1qaoA-3futA:23.93"],["1ZQ9_A_SAMA4000_1","PROBABLE DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",3,"GLY A  54;GLU A  75;ASN A 117","None","0.65A","1zq9A-3futA:24.8","1zq9A-3futA:31.15"],["1ZQ9_B_SAMB4001_0","PROBABLE DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"GLY A  54;GLY A  56;ASP A  99;ASN A 117;LEU A 118;PHE A 184","None","1.13A","1zq9B-3futA:24.1","1zq9B-3futA:31.15"],["1ZQ9_B_SAMB4001_0","PROBABLE DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"GLY A  54;GLY A  56;LEU A  80;ASP A  99;ASN A 117;PHE A 184","None","0.63A","1zq9B-3futA:24.1","1zq9B-3futA:31.15"],["2BM9_B_SAMB301_0","CEPHALOSPORIN HYDROXYLASE CMCI","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"LEU A  91;LEU A  65;GLU A  52;GLY A  58;ALA A   5","None","1.32A","2bm9B-3futA:8.8","2bm9B-3futA:21.15"],["2BXE_A_1FLA2002_1","SERUM ALBUMIN","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"PHE A  51;ALA A  43;LEU A  64;ALA A  67;VAL A  71","None","1.16A","2bxeA-3futA:undetectable","2bxeA-3futA:19.62"],["2NXE_A_SAMA302_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;LEU A  60;ASP A  77;LEU A 126","None","0.86A","2nxeA-3futA:13.0","2nxeA-3futA:27.30"],["2YVL_D_SAMD603_0","HYPOTHETICAL PROTEIN","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;ALA A  59;LEU A  60;ASP A  99","None","0.59A","2yvlD-3futA:13.8","2yvlD-3futA:24.66"],["3B9M_A_SALA1100_1","SERUM ALBUMIN","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"LEU A 267;ARG A 242;LEU A 241;ALA A 235","None","1.17A","3b9mA-3futA:undetectable","3b9mA-3futA:19.62"],["3DXY_A_SAMA1_0","TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"GLU A  52;GLY A  54;GLY A  56;ILE A  74;GLU A  75;ASP A  99;ALA A 100","None","0.76A","3dxyA-3futA:9.3","3dxyA-3futA:26.24"],["3FUU_A_ADNA0_1","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"VAL A  53;GLY A  54;GLY A  56;GLU A  75;ASP A  77;ASP A  99;ALA A 100","None","0.29A","3fuuA-3futA:35.5","3fuuA-3futA:100.00"],["3GRV_A_ADNA300_1","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"GLY A  54;GLY A  56;GLU A  75;ASP A  77;LEU A  80;ASP A  99;ALA A 100","None","0.52A","3grvA-3futA:24.5","3grvA-3futA:29.90"],["3GRV_A_ADNA300_1","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"GLY A  54;GLY A  56;GLU A  75;LEU A  84;ASP A  99;ALA A 100","None","1.39A","3grvA-3futA:24.5","3grvA-3futA:29.90"],["3GRY_A_SAMA300_0","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",9,"LEU A  30;GLU A  52;GLY A  54;GLY A  56;GLU A  75;ASP A  77;LEU A  80;ASP A  99;ALA A 100","None","0.69A","3gryA-3futA:24.4","3gryA-3futA:29.90"],["3GRY_A_SAMA300_0","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"LEU A  30;GLY A  54;GLY A  56;GLU A  75;LEU A  84;ASP A  99;ALA A 100","None","1.46A","3gryA-3futA:24.4","3gryA-3futA:29.90"],["3GRY_A_SAMA300_0","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"LEU A  30;GLY A  56;GLU A  75;ASP A  77;LEU A  80;PRO A 119","None","0.90A","3gryA-3futA:24.4","3gryA-3futA:29.90"],["3GRY_A_SAMA300_0","DIMETHYLADENOSINE TRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"LEU A  60;GLY A  56;GLU A  75;ASP A  77;LEU A  80;ASP A  99","None","1.09A","3gryA-3futA:24.4","3gryA-3futA:29.90"],["3T3Z_A_9PLA501_1","CYTOCHROME P450 2E1","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"PHE A 209;ALA A 202;THR A 200;LEU A 257","None","0.99A","3t3zA-3futA:undetectable","3t3zA-3futA:22.85"],["3T3Z_B_9PLB501_1","CYTOCHROME P450 2E1","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"PHE A 209;ALA A 202;THR A 200;LEU A 257","None","0.98A","3t3zB-3futA:undetectable","3t3zB-3futA:22.85"],["3T3Z_C_9PLC501_1","CYTOCHROME P450 2E1","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"PHE A 209;ALA A 202;THR A 200;LEU A 257","None","1.00A","3t3zC-3futA:undetectable","3t3zC-3futA:22.85"],["3T3Z_D_9PLD501_1","CYTOCHROME P450 2E1","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"PHE A 209;ALA A 202;THR A 200;LEU A 257","None","0.96A","3t3zD-3futA:undetectable","3t3zD-3futA:22.85"],["3VYW_B_SAMB401_0","MNMC2","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;LEU A  57;LYS A  76;ALA A 100","None","0.77A","3vywB-3futA:8.8","3vywB-3futA:24.14"],["3VYW_B_SAMB401_0","MNMC2","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"GLY A  54;GLY A  56;LEU A  57;LYS A  76;LEU A 118","None","0.97A","3vywB-3futA:8.8","3vywB-3futA:24.14"],["4GC9_A_SAMA401_1","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",3,"GLU A  75;ASP A  77;ASP A  99","None","0.28A","4gc9A-3futA:23.7","4gc9A-3futA:31.87"],["5B1B_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"GLN A 144;PHE A 184;LEU A 179;PHE A 177","None","1.06A","5b1bC-3futA:undetectable;5b1bJ-3futA:undetectable","5b1bC-3futA:22.11;5b1bJ-3futA:20.57"],["5CYM_A_T27A601_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"LEU A 130;VAL A 108;TYR A 103;PHE A  51;LEU A 114","None","1.28A","5cymA-3futA:undetectable","5cymA-3futA:20.50"],["5CYQ_A_T27A601_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"LEU A 130;VAL A 108;TYR A 103;PHE A  51;LEU A 114","None","1.29A","5cyqA-3futA:undetectable","5cyqA-3futA:20.50"],["5ERG_B_SAMB401_1","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRM61","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"GLY A  54;GLY A  56;GLU A  75;ASP A  99","None","0.48A","5ergB-3futA:12.4","5ergB-3futA:21.68"],["5MVS_A_ADNA401_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",4,"GLY A  54;GLU A  75;LYS A  76;ASP A  99","None","0.85A","5mvsA-3futA:10.9","5mvsA-3futA:20.87"],["5N5D_B_SAMB303_0","METHYLTRANSFERASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"LEU A  57;ALA A  59;GLU A  52;ILE A  74;GLU A  85","None","1.15A","5n5dB-3futA:12.8","5n5dB-3futA:23.70"],["5X6Y_A_SAMA901_0","MRNA CAPPING ENZYME P5","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"VAL A  53;GLY A  54;GLU A  75;LYS A  76;ASP A  99;ALA A 100;LEU A 126","None","0.96A","5x6yA-3futA:8.1","5x6yA-3futA:15.94"],["5X6Y_A_SAMA901_0","MRNA CAPPING ENZYME P5","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"VAL A  53;GLY A  54;GLU A  75;LYS A  76;LEU A 118","None","1.04A","5x6yA-3futA:8.1","5x6yA-3futA:15.94"],["5X6Y_B_SAMB901_0","MRNA CAPPING ENZYME P5","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"VAL A  53;GLY A  54;GLU A  75;LYS A  76;ASP A  99;ALA A 100;LEU A 126","None","0.95A","5x6yB-3futA:3.3","5x6yB-3futA:15.94"],["5X6Y_B_SAMB901_0","MRNA CAPPING ENZYME P5","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"VAL A  53;GLY A  54;GLU A  75;LYS A  76;LEU A 118","None","0.93A","5x6yB-3futA:3.3","5x6yB-3futA:15.94"],["5X6Y_C_SAMC901_0","MRNA CAPPING ENZYME P5","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"VAL A  53;GLY A  54;GLU A  75;LYS A  76;ASP A  99;ALA A 100;LEU A 126","None","0.88A","5x6yC-3futA:4.3","5x6yC-3futA:15.94"],["5X6Y_C_SAMC901_0","MRNA CAPPING ENZYME P5","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"VAL A  53;GLY A  54;GLU A  75;LYS A  76;LEU A 118","None","0.90A","5x6yC-3futA:4.3","5x6yC-3futA:15.94"],["6ELI_A_T27A701_1","REVERSE TRANSCRIPTASE","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",5,"LEU A 130;VAL A 108;TYR A 103;PHE A  51;LEU A 114","None","1.27A","6eliA-3futA:undetectable","6eliA-3futA:14.56"],["6IFT_A_SAMA301_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",7,"LEU A  30;GLU A  52;GLY A  54;GLY A  56;ALA A  59;ASP A  77;LEU A  80","None","0.54A","6iftA-3futA:29.0","6iftA-3futA:37.33"],["6IFT_A_SAMA301_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","3fut","DIMETHYLADENOSINE TRANSFERASE","Thermus thermophilus",6,"PHE A  29;LEU A  30;GLY A  54;GLY A  56;ASP A  77;LEU A  80","None","0.54A","6iftA-3futA:29.0","6iftA-3futA:37.33"]]