SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FAP_A_RAPA108_2 (FK506-BINDING PROTEIN FRAP)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 8	LEU A 314 SER A 159 GLY A 175 TYR A 182	None	1.09A	1fapB-3fv3A: undetectable	1fapB-3fv3A: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I00_B_D16B409_1 (THYMIDYLATE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 9	ILE A 276 ASP A 306 LEU A 309 GLY A 305 TYR A 14	None	1.35A	1i00B-3fv3A: undetectable	1i00B-3fv3A: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SGU_B_MK1B2632_2 (POL POLYPROTEIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASP A 220 GLY A 222 GLY A 119 ILE A 120 ALA A 196	None	0.92A	1sguB-3fv3A: 7.7	1sguB-3fv3A: 11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SS4_A_ACTA411_0 (GLYOXALASE FAMILY PROTEIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 5	VAL A 278 THR A 277 GLN A 327 ILE A 325	None	1.01A	1ss4A-3fv3A: 1.9	1ss4A-3fv3A: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_A_RBFA300_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 11	GLY A 271 SER A 200 GLU A 189 ILE A 325 ALA A 274	None	1.25A	2a58A-3fv3A: undetectable 2a58E-3fv3A: undetectable	2a58A-3fv3A: 22.47 2a58E-3fv3A: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_B_RBFB301_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ILE A 325 ALA A 274 GLY A 271 SER A 200 GLU A 189	None	1.26A	2a58A-3fv3A: undetectable 2a58B-3fv3A: undetectable	2a58A-3fv3A: 22.47 2a58B-3fv3A: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_C_RBFC302_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ILE A 325 ALA A 274 GLY A 271 SER A 200 GLU A 189	None	1.26A	2a58B-3fv3A: undetectable 2a58C-3fv3A: undetectable	2a58B-3fv3A: 22.47 2a58C-3fv3A: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_D_RBFD303_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 11	ILE A 325 ALA A 274 GLY A 271 SER A 200 GLU A 189	None	1.26A	2a58C-3fv3A: undetectable 2a58D-3fv3A: undetectable	2a58C-3fv3A: 22.47 2a58D-3fv3A: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_E_RBFE304_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ILE A 325 ALA A 274 GLY A 271 SER A 200 GLU A 189	None	1.26A	2a58D-3fv3A: undetectable 2a58E-3fv3A: undetectable	2a58D-3fv3A: 22.47 2a58E-3fv3A: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B60_B_RITB100_2 (GAG-POL POLYPROTEIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 11	ASP A 220 GLY A 222 GLY A 119 ILE A 120 ALA A 196	None	0.97A	2b60B-3fv3A: 7.8	2b60B-3fv3A: 14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B7Z_B_MK1B200_1 (HIV-1 PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASP A 220 GLY A 222 GLY A 119 ILE A 120 ALA A 196	None	0.96A	2b7zA-3fv3A: 7.7	2b7zA-3fv3A: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B7Z_B_MK1B200_2 (HIV-1 PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASP A 220 GLY A 222 GLY A 119 ILE A 120 ALA A 196	None	0.95A	2b7zB-3fv3A: 7.7	2b7zB-3fv3A: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5Q_B_1UNB900_2 (PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 11	ASP A 32 GLY A 34 ASP A 37 ILE A 76 ILE A 117	None	0.84A	2r5qB-3fv3A: 7.4	2r5qB-3fv3A: 14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5Q_D_1UND900_2 (PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 10	ASP A 32 GLY A 34 ASP A 37 ILE A 76 ILE A 117	None	0.84A	2r5qD-3fv3A: 7.6	2r5qD-3fv3A: 14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	6 / 12	ASP A 32 GLY A 34 SER A 35 TYR A 78 ASP A 220 GLY A 222	None	0.33A	2v0zC-3fv3A: 36.0	2v0zC-3fv3A: 27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASP A 220 GLY A 222 ASP A 32 GLY A 34 SER A 36	None	0.88A	2v0zC-3fv3A: 36.0	2v0zC-3fv3A: 27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_1 (RENIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASP A 220 GLY A 222 ASP A 32 GLY A 34 SER A 36	None	0.90A	2v0zO-3fv3A: 35.4	2v0zO-3fv3A: 27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1375_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	3 / 3	LEU A 293 TYR A 285 GLN A 286	None	0.66A	2wekA-3fv3A: undetectable	2wekA-3fv3A: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BUF_A_AEGA394_0 (BETA-SECRETASE 1)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 5	LEU A 218 ASP A 220 ILE A 303 GLY A 34	None	0.45A	3bufA-3fv3A: 32.4	3bufA-3fv3A: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL0_A_1UNA201_1 (PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 8	ASP A 32 GLY A 34 ASP A 37 ILE A 117	None	0.54A	3el0A-3fv3A: 6.7	3el0A-3fv3A: 13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HAV_C_SRYC403_1 (AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASN A 307 ASP A 306 SER A 221 SER A 35 ASP A 32	None	1.44A	3havC-3fv3A: 0.0	3havC-3fv3A: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCN_B_CHDB2_0 (FERROCHELATASE, MITOCHONDRIAL)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	3 / 3	LEU A 314 LEU A 160 ARG A 310	None	0.64A	3hcnB-3fv3A: undetectable	3hcnB-3fv3A: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KK6_A_CELA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	TYR A 313 LEU A 186 SER A 334 ILE A 173 GLY A 175	None	1.02A	3kk6A-3fv3A: undetectable	3kk6A-3fv3A: 18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KK6_B_CELB1701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	TYR A 313 LEU A 186 SER A 334 ILE A 173 GLY A 175	None	1.02A	3kk6B-3fv3A: undetectable	3kk6B-3fv3A: 18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PRS_A_RITA1001_2 (ENDOTHIAPEPSIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	8 / 12	ASP A 32 GLY A 34 GLY A 79 ASP A 80 ASP A 220 THR A 223 TYR A 227 ILE A 303	None None GOL A 341 (-4.5A) None None None GOL A 341 ( 4.6A) None	0.46A	3prsA-3fv3A: 36.9	3prsA-3fv3A: 30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PRS_A_RITA1001_2 (ENDOTHIAPEPSIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	8 / 12	ASP A 32 GLY A 34 GLY A 79 ASP A 114 ASP A 220 THR A 223 TYR A 227 ILE A 303	None None GOL A 341 (-4.5A) None None None GOL A 341 ( 4.6A) None	0.87A	3prsA-3fv3A: 36.9	3prsA-3fv3A: 30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PWW_A_ROCA1001_1 (ENDOTHIAPEPSIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ASP A 32 GLY A 79 THR A 223 TYR A 227 ILE A 303	None GOL A 341 (-4.5A) None GOL A 341 ( 4.6A) None	0.44A	3pwwA-3fv3A: 36.8	3pwwA-3fv3A: 30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PWW_A_ROCA1001_2 (ENDOTHIAPEPSIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	8 / 8	GLY A 34 SER A 35 ILE A 76 TYR A 78 ASP A 80 SER A 82 ASP A 220 THR A 224	None	0.55A	3pwwA-3fv3A: 36.8	3pwwA-3fv3A: 30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q70_A_RITA2001_1 (CANDIDAPEPSIN-2)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	9 / 12	ILE A 30 ASP A 32 GLY A 34 GLY A 79 ASN A 125 ASP A 220 THR A 223 TYR A 227 ILE A 303	None None None GOL A 341 (-4.5A) None None None GOL A 341 ( 4.6A) None	0.37A	3q70A-3fv3A: 13.9	3q70A-3fv3A: 51.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q70_A_RITA2001_1 (CANDIDAPEPSIN-2)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	6 / 12	ILE A 30 ASP A 32 GLY A 34 SER A 84 ASN A 125 ASP A 220	None	1.43A	3q70A-3fv3A: 13.9	3q70A-3fv3A: 51.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q70_A_RITA2001_1 (CANDIDAPEPSIN-2)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	8 / 12	ILE A 117 ASP A 32 GLY A 34 GLY A 79 ASP A 220 THR A 223 TYR A 227 ILE A 303	None None None GOL A 341 (-4.5A) None None GOL A 341 ( 4.6A) None	1.20A	3q70A-3fv3A: 13.9	3q70A-3fv3A: 51.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q70_A_RITA2001_2 (CANDIDAPEPSIN-2)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 6	SER A 35 ILE A 76 TYR A 78 ASP A 114 THR A 224	None	0.45A	3q70A-3fv3A: 13.9	3q70A-3fv3A: 51.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROD_D_NCAD302_0 (NICOTINAMIDE N-METHYLTRANSFERASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 7	LEU A 318 ASP A 319 ALA A 320 TYR A 158	None	1.02A	3rodD-3fv3A: undetectable	3rodD-3fv3A: 21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TNE_A_RITA401_1 (SECRETED ASPARTIC PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	12 / 12	ILE A 30 ASP A 32 GLY A 34 ILE A 76 GLY A 79 ASP A 80 SER A 82 ASP A 114 ASN A 125 ASP A 220 TYR A 227 ILE A 303	None None None None GOL A 341 (-4.5A) None None None None None GOL A 341 ( 4.6A) None	0.42A	3tneA-3fv3A: 55.9	3tneA-3fv3A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TNE_A_RITA401_1 (SECRETED ASPARTIC PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	10 / 12	ILE A 117 ASP A 32 GLY A 34 GLY A 79 ASP A 80 SER A 82 ASP A 114 ASP A 220 TYR A 227 ILE A 303	None None None GOL A 341 (-4.5A) None None None None GOL A 341 ( 4.6A) None	1.29A	3tneA-3fv3A: 55.9	3tneA-3fv3A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TNE_A_RITA401_2 (SECRETED ASPARTIC PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	6 / 6	PRO A 12 SER A 35 TYR A 78 VAL A 113 THR A 223 THR A 224	None	0.29A	3tneA-3fv3A: 55.9	3tneA-3fv3A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TNE_B_RITB401_1 (SECRETED ASPARTIC PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	12 / 12	ILE A 30 ASP A 32 GLY A 34 ILE A 76 GLY A 79 ASP A 80 SER A 82 ASP A 114 ASN A 125 ASP A 220 ASP A 301 ILE A 303	None None None None GOL A 341 (-4.5A) None None None None None GOL A 341 (-3.6A) None	0.47A	3tneB-3fv3A: 56.2	3tneB-3fv3A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TNE_B_RITB401_1 (SECRETED ASPARTIC PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	9 / 12	ILE A 117 ASP A 32 GLY A 34 GLY A 79 ASP A 80 SER A 82 ASP A 220 ASP A 301 ILE A 303	None None None GOL A 341 (-4.5A) None None None GOL A 341 (-3.6A) None	1.25A	3tneB-3fv3A: 56.2	3tneB-3fv3A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TNE_B_RITB401_2 (SECRETED ASPARTIC PROTEASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	7 / 7	SER A 35 TYR A 78 VAL A 113 ILE A 117 THR A 223 THR A 224 TYR A 227	None None None None None None GOL A 341 ( 4.6A)	0.27A	3tneB-3fv3A: 56.2	3tneB-3fv3A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DA6_A_GA2A301_1 (PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 9	SER A 4 GLY A 176 VAL A 177 SER A 2 VAL A 339	None	1.41A	4da6A-3fv3A: undetectable	4da6A-3fv3A: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IQQ_D_D16D402_1 (THYMIDYLATE SYNTHASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 8	ILE A 276 ASP A 306 LEU A 309 GLY A 305 TYR A 14	None	1.33A	4iqqD-3fv3A: undetectable	4iqqD-3fv3A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LV9_A_20JA602_1 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 7	TYR A 158 VAL A 143 ILE A 95 ILE A 3	None	0.88A	4lv9A-3fv3A: undetectable	4lv9A-3fv3A: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QTU_D_SAMD301_0 (PUTATIVE METHYLTRANSFERASE BUD23)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	GLY A 271 GLY A 273 ILE A 199 SER A 203 ALA A 202	None	1.13A	4qtuD-3fv3A: undetectable	4qtuD-3fv3A: 20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	4 / 6	GLY A 119 ASP A 37 GLY A 34 SER A 82	None	1.00A	4z53A-3fv3A: undetectable 4z53B-3fv3A: undetectable	4z53A-3fv3A: 16.96 4z53B-3fv3A: 16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESH_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	ALA A 180 TYR A 14 ILE A 30 GLY A 34 LEU A 309	None	1.16A	5eshA-3fv3A: undetectable	5eshA-3fv3A: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUG_A_VIVA301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	5 / 12	VAL A 20 ILE A 8 ILE A 95 LEU A 5 ILE A 31	None	0.95A	5mugA-3fv3A: undetectable	5mugA-3fv3A: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHB_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	3 / 3	PHE A 308 ASP A 306 LEU A 253	None	0.76A	5uhbC-3fv3A: undetectable	5uhbC-3fv3A: 15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHC_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	3fv3	SAPP1P-SECRETED ASPARTIC PROTEASE 1 (Candida parapsilosis)	3 / 3	PHE A 308 ASP A 306 LEU A 253	None	0.75A	5uhcC-3fv3A: undetectable	5uhcC-3fv3A: 15.02

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FAP_A_RAPA108_2","FK506-BINDING PROTEIN;FRAP","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"LEU A 314;SER A 159;GLY A 175;TYR A 182","None","1.09A","1fapB-3fv3A:undetectable","1fapB-3fv3A:12.98"],["1I00_B_D16B409_1","THYMIDYLATE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ILE A 276;ASP A 306;LEU A 309;GLY A 305;TYR A  14","None","1.35A","1i00B-3fv3A:undetectable","1i00B-3fv3A:19.72"],["1SGU_B_MK1B2632_2","POL POLYPROTEIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A 220;GLY A 222;GLY A 119;ILE A 120;ALA A 196","None","0.92A","1sguB-3fv3A:7.7","1sguB-3fv3A:11.50"],["1SS4_A_ACTA411_0","GLYOXALASE FAMILY PROTEIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"VAL A 278;THR A 277;GLN A 327;ILE A 325","None","1.01A","1ss4A-3fv3A:1.9","1ss4A-3fv3A:16.72"],["2A58_A_RBFA300_1","6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE;6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"GLY A 271;SER A 200;GLU A 189;ILE A 325;ALA A 274","None","1.25A","2a58A-3fv3A:undetectable;2a58E-3fv3A:undetectable","2a58A-3fv3A:22.47;2a58E-3fv3A:22.47"],["2A58_B_RBFB301_1","6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE;6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ILE A 325;ALA A 274;GLY A 271;SER A 200;GLU A 189","None","1.26A","2a58A-3fv3A:undetectable;2a58B-3fv3A:undetectable","2a58A-3fv3A:22.47;2a58B-3fv3A:22.47"],["2A58_C_RBFC302_1","6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE;6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ILE A 325;ALA A 274;GLY A 271;SER A 200;GLU A 189","None","1.26A","2a58B-3fv3A:undetectable;2a58C-3fv3A:undetectable","2a58B-3fv3A:22.47;2a58C-3fv3A:22.47"],["2A58_D_RBFD303_1","6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE;6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ILE A 325;ALA A 274;GLY A 271;SER A 200;GLU A 189","None","1.26A","2a58C-3fv3A:undetectable;2a58D-3fv3A:undetectable","2a58C-3fv3A:22.47;2a58D-3fv3A:22.47"],["2A58_E_RBFE304_1","6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE;6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ILE A 325;ALA A 274;GLY A 271;SER A 200;GLU A 189","None","1.26A","2a58D-3fv3A:undetectable;2a58E-3fv3A:undetectable","2a58D-3fv3A:22.47;2a58E-3fv3A:22.47"],["2B60_B_RITB100_2","GAG-POL POLYPROTEIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A 220;GLY A 222;GLY A 119;ILE A 120;ALA A 196","None","0.97A","2b60B-3fv3A:7.8","2b60B-3fv3A:14.07"],["2B7Z_B_MK1B200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A 220;GLY A 222;GLY A 119;ILE A 120;ALA A 196","None","0.96A","2b7zA-3fv3A:7.7","2b7zA-3fv3A:12.98"],["2B7Z_B_MK1B200_2","HIV-1 PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A 220;GLY A 222;GLY A 119;ILE A 120;ALA A 196","None","0.95A","2b7zB-3fv3A:7.7","2b7zB-3fv3A:12.98"],["2R5Q_B_1UNB900_2","PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A  32;GLY A  34;ASP A  37;ILE A  76;ILE A 117","None","0.84A","2r5qB-3fv3A:7.4","2r5qB-3fv3A:14.37"],["2R5Q_D_1UND900_2","PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A  32;GLY A  34;ASP A  37;ILE A  76;ILE A 117","None","0.84A","2r5qD-3fv3A:7.6","2r5qD-3fv3A:14.37"],["2V0Z_C_C41C1328_1","RENIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",6,"ASP A  32;GLY A  34;SER A  35;TYR A  78;ASP A 220;GLY A 222","None","0.33A","2v0zC-3fv3A:36.0","2v0zC-3fv3A:27.30"],["2V0Z_C_C41C1328_1","RENIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A 220;GLY A 222;ASP A  32;GLY A  34;SER A  36","None","0.88A","2v0zC-3fv3A:36.0","2v0zC-3fv3A:27.30"],["2V0Z_O_C41O1327_1","RENIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A 220;GLY A 222;ASP A  32;GLY A  34;SER A  36","None","0.90A","2v0zO-3fv3A:35.4","2v0zO-3fv3A:27.30"],["2WEK_A_DIFA1375_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",3,"LEU A 293;TYR A 285;GLN A 286","None","0.66A","2wekA-3fv3A:undetectable","2wekA-3fv3A:22.63"],["3BUF_A_AEGA394_0","BETA-SECRETASE 1","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"LEU A 218;ASP A 220;ILE A 303;GLY A  34","None","0.45A","3bufA-3fv3A:32.4","3bufA-3fv3A:24.41"],["3EL0_A_1UNA201_1","PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"ASP A  32;GLY A  34;ASP A  37;ILE A 117","None","0.54A","3el0A-3fv3A:6.7","3el0A-3fv3A:13.47"],["3HAV_C_SRYC403_1","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASN A 307;ASP A 306;SER A 221;SER A  35;ASP A  32","None","1.44A","3havC-3fv3A:0.0","3havC-3fv3A:19.05"],["3HCN_B_CHDB2_0","FERROCHELATASE, MITOCHONDRIAL","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",3,"LEU A 314;LEU A 160;ARG A 310","None","0.64A","3hcnB-3fv3A:undetectable","3hcnB-3fv3A:18.65"],["3KK6_A_CELA701_1","PROSTAGLANDIN G\/H SYNTHASE 1","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"TYR A 313;LEU A 186;SER A 334;ILE A 173;GLY A 175","None","1.02A","3kk6A-3fv3A:undetectable","3kk6A-3fv3A:18.27"],["3KK6_B_CELB1701_1","PROSTAGLANDIN G\/H SYNTHASE 1","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"TYR A 313;LEU A 186;SER A 334;ILE A 173;GLY A 175","None","1.02A","3kk6B-3fv3A:undetectable","3kk6B-3fv3A:18.27"],["3PRS_A_RITA1001_2","ENDOTHIAPEPSIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",8,"ASP A  32;GLY A  34;GLY A  79;ASP A  80;ASP A 220;THR A 223;TYR A 227;ILE A 303","None;None;GOL A 341 (-4.5A);None;None;None;GOL A 341 ( 4.6A);None","0.46A","3prsA-3fv3A:36.9","3prsA-3fv3A:30.77"],["3PRS_A_RITA1001_2","ENDOTHIAPEPSIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",8,"ASP A  32;GLY A  34;GLY A  79;ASP A 114;ASP A 220;THR A 223;TYR A 227;ILE A 303","None;None;GOL A 341 (-4.5A);None;None;None;GOL A 341 ( 4.6A);None","0.87A","3prsA-3fv3A:36.9","3prsA-3fv3A:30.77"],["3PWW_A_ROCA1001_1","ENDOTHIAPEPSIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ASP A  32;GLY A  79;THR A 223;TYR A 227;ILE A 303","None;GOL A 341 (-4.5A);None;GOL A 341 ( 4.6A);None","0.44A","3pwwA-3fv3A:36.8","3pwwA-3fv3A:30.77"],["3PWW_A_ROCA1001_2","ENDOTHIAPEPSIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",8,"GLY A  34;SER A  35;ILE A  76;TYR A  78;ASP A  80;SER A  82;ASP A 220;THR A 224","None","0.55A","3pwwA-3fv3A:36.8","3pwwA-3fv3A:30.77"],["3Q70_A_RITA2001_1","CANDIDAPEPSIN-2","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",9,"ILE A  30;ASP A  32;GLY A  34;GLY A  79;ASN A 125;ASP A 220;THR A 223;TYR A 227;ILE A 303","None;None;None;GOL A 341 (-4.5A);None;None;None;GOL A 341 ( 4.6A);None","0.37A","3q70A-3fv3A:13.9","3q70A-3fv3A:51.99"],["3Q70_A_RITA2001_1","CANDIDAPEPSIN-2","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",6,"ILE A  30;ASP A  32;GLY A  34;SER A  84;ASN A 125;ASP A 220","None","1.43A","3q70A-3fv3A:13.9","3q70A-3fv3A:51.99"],["3Q70_A_RITA2001_1","CANDIDAPEPSIN-2","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",8,"ILE A 117;ASP A  32;GLY A  34;GLY A  79;ASP A 220;THR A 223;TYR A 227;ILE A 303","None;None;None;GOL A 341 (-4.5A);None;None;GOL A 341 ( 4.6A);None","1.20A","3q70A-3fv3A:13.9","3q70A-3fv3A:51.99"],["3Q70_A_RITA2001_2","CANDIDAPEPSIN-2","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"SER A  35;ILE A  76;TYR A  78;ASP A 114;THR A 224","None","0.45A","3q70A-3fv3A:13.9","3q70A-3fv3A:51.99"],["3ROD_D_NCAD302_0","NICOTINAMIDE N-METHYLTRANSFERASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"LEU A 318;ASP A 319;ALA A 320;TYR A 158","None","1.02A","3rodD-3fv3A:undetectable","3rodD-3fv3A:21.90"],["3TNE_A_RITA401_1","SECRETED ASPARTIC PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",12,"ILE A  30;ASP A  32;GLY A  34;ILE A  76;GLY A  79;ASP A  80;SER A  82;ASP A 114;ASN A 125;ASP A 220;TYR A 227;ILE A 303","None;None;None;None;GOL A 341 (-4.5A);None;None;None;None;None;GOL A 341 ( 4.6A);None","0.42A","3tneA-3fv3A:55.9","3tneA-3fv3A:100.00"],["3TNE_A_RITA401_1","SECRETED ASPARTIC PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",10,"ILE A 117;ASP A  32;GLY A  34;GLY A  79;ASP A  80;SER A  82;ASP A 114;ASP A 220;TYR A 227;ILE A 303","None;None;None;GOL A 341 (-4.5A);None;None;None;None;GOL A 341 ( 4.6A);None","1.29A","3tneA-3fv3A:55.9","3tneA-3fv3A:100.00"],["3TNE_A_RITA401_2","SECRETED ASPARTIC PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",6,"PRO A  12;SER A  35;TYR A  78;VAL A 113;THR A 223;THR A 224","None","0.29A","3tneA-3fv3A:55.9","3tneA-3fv3A:100.00"],["3TNE_B_RITB401_1","SECRETED ASPARTIC PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",12,"ILE A  30;ASP A  32;GLY A  34;ILE A  76;GLY A  79;ASP A  80;SER A  82;ASP A 114;ASN A 125;ASP A 220;ASP A 301;ILE A 303","None;None;None;None;GOL A 341 (-4.5A);None;None;None;None;None;GOL A 341 (-3.6A);None","0.47A","3tneB-3fv3A:56.2","3tneB-3fv3A:100.00"],["3TNE_B_RITB401_1","SECRETED ASPARTIC PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",9,"ILE A 117;ASP A  32;GLY A  34;GLY A  79;ASP A  80;SER A  82;ASP A 220;ASP A 301;ILE A 303","None;None;None;GOL A 341 (-4.5A);None;None;None;GOL A 341 (-3.6A);None","1.25A","3tneB-3fv3A:56.2","3tneB-3fv3A:100.00"],["3TNE_B_RITB401_2","SECRETED ASPARTIC PROTEASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",7,"SER A  35;TYR A  78;VAL A 113;ILE A 117;THR A 223;THR A 224;TYR A 227","None;None;None;None;None;None;GOL A 341 ( 4.6A)","0.27A","3tneB-3fv3A:56.2","3tneB-3fv3A:100.00"],["4DA6_A_GA2A301_1","PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"SER A   4;GLY A 176;VAL A 177;SER A   2;VAL A 339","None","1.41A","4da6A-3fv3A:undetectable","4da6A-3fv3A:23.71"],["4IQQ_D_D16D402_1","THYMIDYLATE SYNTHASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ILE A 276;ASP A 306;LEU A 309;GLY A 305;TYR A  14","None","1.33A","4iqqD-3fv3A:undetectable","4iqqD-3fv3A:21.98"],["4LV9_A_20JA602_1","NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"TYR A 158;VAL A 143;ILE A  95;ILE A   3","None","0.88A","4lv9A-3fv3A:undetectable","4lv9A-3fv3A:20.89"],["4QTU_D_SAMD301_0","PUTATIVE METHYLTRANSFERASE BUD23","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"GLY A 271;GLY A 273;ILE A 199;SER A 203;ALA A 202","None","1.13A","4qtuD-3fv3A:undetectable","4qtuD-3fv3A:20.23"],["4Z53_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",4,"GLY A 119;ASP A  37;GLY A  34;SER A  82","None","1.00A","4z53A-3fv3A:undetectable;4z53B-3fv3A:undetectable","4z53A-3fv3A:16.96;4z53B-3fv3A:16.96"],["5ESH_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"ALA A 180;TYR A  14;ILE A  30;GLY A  34;LEU A 309","None","1.16A","5eshA-3fv3A:undetectable","5eshA-3fv3A:19.07"],["5MUG_A_VIVA301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",5,"VAL A  20;ILE A   8;ILE A  95;LEU A   5;ILE A  31","None","0.95A","5mugA-3fv3A:undetectable","5mugA-3fv3A:20.45"],["5UHB_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",3,"PHE A 308;ASP A 306;LEU A 253","None","0.76A","5uhbC-3fv3A:undetectable","5uhbC-3fv3A:15.02"],["5UHC_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","3fv3","SAPP1P-SECRETED ASPARTIC PROTEASE 1","Candida parapsilosis",3,"PHE A 308;ASP A 306;LEU A 253","None","0.75A","5uhcC-3fv3A:undetectable","5uhcC-3fv3A:15.02"]]