SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 9 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ALA A  86
ILE A  90
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.7A)
 0.69A 1aj6A-3fv5A:
26.7		 1aj6A-3fv5A:
47.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 6 PHE A 167
PHE A 179
GLU A  38
GLY A  36
 None
 0.89A 1icuA-3fv5A:
undetectable
1icuB-3fv5A:
undetectable		 1icuA-3fv5A:
20.09
1icuB-3fv5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 ASP A  45
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ILE A  90
ARG A 132
THR A 163
 None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.56A 1kijA-3fv5A:
27.2		 1kijA-3fv5A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.95A 1kijA-3fv5A:
27.2		 1kijA-3fv5A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.91A 1kijB-3fv5A:
27.6		 1kijB-3fv5A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 6 PHE A 179
GLU A  38
GLY A  36
PHE A 167
 None
 0.93A 1kqbC-3fv5A:
undetectable
1kqbD-3fv5A:
undetectable		 1kqbC-3fv5A:
20.85
1kqbD-3fv5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 6 PHE A 179
GLU A  38
GLY A  36
THR A  27
 None
 1.16A 1kqbC-3fv5A:
undetectable
1kqbD-3fv5A:
undetectable		 1kqbC-3fv5A:
20.85
1kqbD-3fv5A:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		11 / 12 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.38A 1s14A-3fv5A:
29.5		 1s14A-3fv5A:
88.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		11 / 12 ASN A  42
SER A  43
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ASP A  77
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.72A 1s14A-3fv5A:
29.5		 1s14A-3fv5A:
88.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		11 / 12 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ALA A  86
ILE A  90
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
 0.45A 1s14B-3fv5A:
32.1		 1s14B-3fv5A:
88.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		11 / 12 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ASP A  77
ILE A  90
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
 0.77A 1s14B-3fv5A:
32.1		 1s14B-3fv5A:
88.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 7 VAL A 126
GLY A 144
ALA A 121
LEU A 122
 None
 0.91A 2wekB-3fv5A:
undetectable		 2wekB-3fv5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 4 LEU A  35
ALA A 121
VAL A  19
PRO A  23
 None
 1.00A 3gv1B-3fv5A:
undetectable		 3gv1B-3fv5A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		11 / 12 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.54A 3lpsA-3fv5A:
31.0		 3lpsA-3fv5A:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		9 / 12 SER A  43
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ASP A  77
ARG A 132
THR A 163
 1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 1.01A 3lpsA-3fv5A:
31.0		 3lpsA-3fv5A:
40.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 12 ALA A 140
GLY A 144
ASN A 143
THR A  27
LEU A  35
 None
 1.01A 4n49A-3fv5A:
undetectable		 4n49A-3fv5A:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		9 / 11 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.81A 4urnA-3fv5A:
28.1		 4urnA-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		10 / 11 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.66A 4urnA-3fv5A:
28.1		 4urnA-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 11 ASP A  45
GLU A  46
ASP A  69
ILE A 116
THR A 163
 None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
None
1EU  A   2 (-3.7A)
 1.31A 4urnA-3fv5A:
28.1		 4urnA-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		10 / 11 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.57A 4urnB-3fv5A:
26.5		 4urnB-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		10 / 11 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.69A 4urnB-3fv5A:
26.5		 4urnB-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 11 ASP A  45
GLU A  46
ASP A  69
ILE A 116
THR A 163
 None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
None
1EU  A   2 (-3.7A)
 1.44A 4urnB-3fv5A:
26.5		 4urnB-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		11 / 11 ASN A  42
SER A  43
ASP A  45
GLU A  46
ASP A  69
ARG A  72
MET A  74
PRO A  75
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.4A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.64A 4urnC-3fv5A:
28.5		 4urnC-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 11 ASP A  45
GLU A  46
ASP A  69
ILE A 116
THR A 163
 None
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
None
1EU  A   2 (-3.7A)
 1.42A 4urnC-3fv5A:
28.5		 4urnC-3fv5A:
45.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  42
SER A  43
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-3.9A)
 1.05A 4uroA-3fv5A:
28.0		 4uroA-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  42
SER A  43
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ILE A  90
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
 0.69A 4uroA-3fv5A:
28.0		 4uroA-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  42
SER A  43
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-3.9A)
 1.03A 4uroB-3fv5A:
28.3		 4uroB-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  42
SER A  43
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ILE A  90
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
 0.64A 4uroB-3fv5A:
28.3		 4uroB-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ALA A  86
ILE A  90
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
 0.63A 4uroC-3fv5A:
28.5		 4uroC-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		7 / 12 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-3.9A)
 1.16A 4uroC-3fv5A:
28.5		 4uroC-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  42
SER A  43
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.62A 4uroD-3fv5A:
27.8		 4uroD-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		8 / 12 SER A  43
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ARG A 132
THR A 163
 1EU  A   2 (-3.0A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.97A 4uroD-3fv5A:
27.8		 4uroD-3fv5A:
46.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A 123
PRO A 169
PHE A 179
HIS A 166
VAL A 126
 None
 1.31A 4yfbC-3fv5A:
undetectable		 4yfbC-3fv5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A 123
PRO A 169
PHE A 179
HIS A 166
VAL A 126
 None
 1.30A 4yfbF-3fv5A:
undetectable		 4yfbF-3fv5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A 123
PRO A 169
PHE A 179
HIS A 166
VAL A 126
 None
 1.30A 4yfbI-3fv5A:
undetectable		 4yfbI-3fv5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		5 / 12 SER A 123
PRO A 169
PHE A 179
HIS A 166
VAL A 126
 None
 1.31A 4yfbL-3fv5A:
undetectable		 4yfbL-3fv5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		3 / 3 GLU A 171
TRP A 168
ASN A 143
 None
 1.04A 5dv4A-3fv5A:
undetectable		 5dv4A-3fv5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 6 ARG A  72
PRO A  75
THR A 163
GLU A  46
 1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
1EU  A   2 (-3.7A)
1EU  A   2 (-3.4A)
 1.07A 5ny7A-3fv5A:
2.0		 5ny7A-3fv5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		4 / 6 GLU A  82
ARG A  93
GLU A  88
ALA A  86
 None
 1.21A 6an0A-3fv5A:
undetectable		 6an0A-3fv5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		3 / 3 ARG A  21
LYS A  15
TYR A  26
 None
 1.17A 6gnaA-3fv5A:
undetectable		 6gnaA-3fv5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3fv5 DNA TOPOISOMERASE 4
SUBUNIT B
(Escherichia
coli) 		3 / 3 ARG A  21
LYS A  15
TYR A  26
 None
 1.17A 6gnbA-3fv5A:
undetectable		 6gnbA-3fv5A:
20.55