SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 256
HIS A 251
ALA A 237
LEU A 248
THR A 249
 None
 1.19A 3mdzA-3fveA:
undetectable		 3mdzA-3fveA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A 113
ARG A 118
PRO A 119
VAL A 110
 None
None
None
GOL  A 291 (-3.5A)
 1.33A 3sufC-3fveA:
undetectable		 3sufC-3fveA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 229
GLY A 227
VAL A 161
VAL A 259
 None
 0.85A 4c5nC-3fveA:
undetectable		 4c5nC-3fveA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 156
GLY A 143
ALA A 167
LEU A 157
HIS A 165
 None
 1.07A 4l8fB-3fveA:
undetectable		 4l8fB-3fveA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 156
GLY A 143
ALA A 167
LEU A 157
HIS A 165
 None
 1.08A 4l8fD-3fveA:
undetectable		 4l8fD-3fveA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 199
GLU A 217
GLU A 222
GLU A 201
 None
 1.34A 4mj8C-3fveA:
undetectable		 4mj8C-3fveA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 141
VAL A 257
VAL A 261
GLY A 246
 None
 1.00A 4mk4A-3fveA:
undetectable		 4mk4A-3fveA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A 262
THR A 265
THR A 121
HIS A 123
 None
None
None
GOL  A 292 (-4.2A)
 1.15A 4pgfA-3fveA:
undetectable		 4pgfA-3fveA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 5 THR A 262
THR A 265
THR A 121
HIS A 123
 None
None
None
GOL  A 292 (-4.2A)
 1.17A 4pgfB-3fveA:
undetectable		 4pgfB-3fveA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 199
GLU A 217
GLU A 222
GLU A 201
 None
 1.25A 4r87I-3fveA:
undetectable		 4r87I-3fveA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3fve DIAMINOPIMELATE
EPIMERASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 134
GLY A 270
SER A 272
GLY A   8
 None
None
None
DTT  A 290 (-3.6A)
 0.90A 5e26C-3fveA:
undetectable
5e26D-3fveA:
undetectable		 5e26C-3fveA:
20.05
5e26D-3fveA:
20.05