SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJF_A_ADNA2001_1 (235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA- CARBOXYLASE] LIGASE)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 7	ARG A 228 GLU A 225 ALA A 236 ALA A 235	None	1.05A	2ejfA-3fvqA: undetectable	2ejfA-3fvqA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYR_B_SVRB401_2 (NAD-DEPENDENT DEACETYLASE SIRTUIN-5)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 6	PHE A 53 GLN A 55 ASN A 74 ASN A 21	None	1.17A	2nyrA-3fvqA: undetectable	2nyrA-3fvqA: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_A_SAMA201_0 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	5 / 12	GLY A 274 ALA A 248 GLY A 271 ALA A 270 LEU A 233	None	1.03A	2nyuA-3fvqA: undetectable	2nyuA-3fvqA: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_A_ACTA141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	3 / 3	VAL A 86 ASP A 163 GLU A 88	None CA A 360 ( 4.0A) None	0.70A	2qeuA-3fvqA: undetectable	2qeuA-3fvqA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_C_ACTC141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	3 / 3	VAL A 86 ASP A 163 GLU A 88	None CA A 360 ( 4.0A) None	0.68A	2qeuC-3fvqA: undetectable	2qeuC-3fvqA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_C_CHDC151_0 (ILEAL BILE ACID-BINDING PROTEIN)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	5 / 10	ILE A 7 ILE A 61 GLY A 52 VAL A 193 LEU A 20	None	1.23A	3elzC-3fvqA: undetectable	3elzC-3fvqA: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_A_CHDA151_0 (ILEAL BILE ACID-BINDING PROTEIN)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	5 / 10	ILE A 7 ILE A 61 GLY A 52 VAL A 193 LEU A 20	None	1.19A	3em0A-3fvqA: undetectable	3em0A-3fvqA: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q1E_C_T44C128_1 (5-HYDROXYISOURATE HYDROLASE)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 6	LEU A 82 PRO A 157 LEU A 159 LEU A 162	None	0.85A	3q1eA-3fvqA: undetectable 3q1eC-3fvqA: undetectable	3q1eA-3fvqA: 16.42 3q1eC-3fvqA: 16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q1E_C_T44C128_1 (5-HYDROXYISOURATE HYDROLASE)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 6	LEU A 162 LEU A 82 PRO A 157 LEU A 159	None	0.87A	3q1eA-3fvqA: undetectable 3q1eC-3fvqA: undetectable	3q1eA-3fvqA: 16.42 3q1eC-3fvqA: 16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW1_B_CVIB301_0 (PUTATIVE REGULATORY PROTEIN)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	5 / 12	LEU A 185 ILE A 160 ALA A 152 PHE A 166 LEU A 169	None	1.09A	3vw1B-3fvqA: undetectable	3vw1B-3fvqA: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 6	LEU A 33 LEU A 25 ILE A 23 MET A 212	None	0.98A	4do3B-3fvqA: undetectable	4do3B-3fvqA: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EQ4_A_SALA601_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 7	LEU A 173 THR A 126 ILE A 128 GLY A 142	None	0.97A	4eq4A-3fvqA: 0.7	4eq4A-3fvqA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNV_D_QI9D602_0 (CYTOCHROME P450 2D6)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 7	LEU A 47 THR A 220 VAL A 193 PHE A 34	None	1.04A	4wnvD-3fvqA: undetectable	4wnvD-3fvqA: 23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWX_A_SAMA301_1 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	3 / 3	ARG A 80 ASN A 74 ASP A 57	None	0.85A	5gwxA-3fvqA: 2.2	5gwxA-3fvqA: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HS6_A_J3ZA302_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE 14)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 8	GLN A 282 TYR A 283 LEU A 259 LEU A 262	None	1.13A	5hs6A-3fvqA: undetectable	5hs6A-3fvqA: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGP_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	5 / 12	VAL A 86 ALA A 147 ALA A 148 VAL A 90 GLY A 142	None	1.42A	5igpA-3fvqA: undetectable	5igpA-3fvqA: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IY5_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 5	ARG A 208 LEU A 33 PHE A 194 LEU A 27	None	1.19A	5iy5P-3fvqA: undetectable 5iy5W-3fvqA: undetectable	5iy5P-3fvqA: 21.10 5iy5W-3fvqA: 11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDX_C_CHDC308_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 5	ARG A 208 LEU A 33 PHE A 194 LEU A 27	None	1.25A	5xdxC-3fvqA: undetectable 5xdxJ-3fvqA: undetectable	5xdxC-3fvqA: 21.04 5xdxJ-3fvqA: 11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDX_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	4 / 5	ARG A 208 LEU A 33 PHE A 194 LEU A 27	None	1.25A	5xdxP-3fvqA: undetectable 5xdxW-3fvqA: undetectable	5xdxP-3fvqA: 21.04 5xdxW-3fvqA: 11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Z_D_9CRD501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3fvq	FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC (Neisseria gonorrhoeae)	5 / 12	ILE A 7 ILE A 35 LEU A 5 ILE A 217 LEU A 20	None	1.16A	6a5zD-3fvqA: undetectable	6a5zD-3fvqA: 16.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EJF_A_ADNA2001_1","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"ARG A 228;GLU A 225;ALA A 236;ALA A 235","None","1.05A","2ejfA-3fvqA:undetectable","2ejfA-3fvqA:20.65"],["2NYR_B_SVRB401_2","NAD-DEPENDENT DEACETYLASE SIRTUIN-5;NAD-DEPENDENT DEACETYLASE SIRTUIN-5","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"PHE A  53;GLN A  55;ASN A  74;ASN A  21","None","1.17A","2nyrA-3fvqA:undetectable","2nyrA-3fvqA:22.19"],["2NYU_A_SAMA201_0","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",5,"GLY A 274;ALA A 248;GLY A 271;ALA A 270;LEU A 233","None","1.03A","2nyuA-3fvqA:undetectable","2nyuA-3fvqA:19.39"],["2QEU_A_ACTA141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",3,"VAL A  86;ASP A 163;GLU A  88","None; CA A 360 ( 4.0A);None","0.70A","2qeuA-3fvqA:undetectable","2qeuA-3fvqA:21.02"],["2QEU_C_ACTC141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",3,"VAL A  86;ASP A 163;GLU A  88","None; CA A 360 ( 4.0A);None","0.68A","2qeuC-3fvqA:undetectable","2qeuC-3fvqA:21.02"],["3ELZ_C_CHDC151_0","ILEAL BILE ACID-BINDING PROTEIN","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",5,"ILE A   7;ILE A  61;GLY A  52;VAL A 193;LEU A  20","None","1.23A","3elzC-3fvqA:undetectable","3elzC-3fvqA:15.28"],["3EM0_A_CHDA151_0","ILEAL BILE ACID-BINDING PROTEIN","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",5,"ILE A   7;ILE A  61;GLY A  52;VAL A 193;LEU A  20","None","1.19A","3em0A-3fvqA:undetectable","3em0A-3fvqA:15.28"],["3Q1E_C_T44C128_1","5-HYDROXYISOURATE HYDROLASE;5-HYDROXYISOURATE HYDROLASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"LEU A  82;PRO A 157;LEU A 159;LEU A 162","None","0.85A","3q1eA-3fvqA:undetectable;3q1eC-3fvqA:undetectable","3q1eA-3fvqA:16.42;3q1eC-3fvqA:16.42"],["3Q1E_C_T44C128_1","5-HYDROXYISOURATE HYDROLASE;5-HYDROXYISOURATE HYDROLASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"LEU A 162;LEU A  82;PRO A 157;LEU A 159","None","0.87A","3q1eA-3fvqA:undetectable;3q1eC-3fvqA:undetectable","3q1eA-3fvqA:16.42;3q1eC-3fvqA:16.42"],["3VW1_B_CVIB301_0","PUTATIVE REGULATORY PROTEIN","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",5,"LEU A 185;ILE A 160;ALA A 152;PHE A 166;LEU A 169","None","1.09A","3vw1B-3fvqA:undetectable","3vw1B-3fvqA:20.85"],["4DO3_B_0LAB602_1","FATTY-ACID AMIDE HYDROLASE 1","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"LEU A  33;LEU A  25;ILE A  23;MET A 212","None","0.98A","4do3B-3fvqA:undetectable","4do3B-3fvqA:22.16"],["4EQ4_A_SALA601_1","4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"LEU A 173;THR A 126;ILE A 128;GLY A 142","None","0.97A","4eq4A-3fvqA:0.7","4eq4A-3fvqA:20.30"],["4WNV_D_QI9D602_0","CYTOCHROME P450 2D6","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"LEU A  47;THR A 220;VAL A 193;PHE A  34","None","1.04A","4wnvD-3fvqA:undetectable","4wnvD-3fvqA:23.35"],["5GWX_A_SAMA301_1","GLYCINE SARCOSINE N-METHYLTRANSFERASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",3,"ARG A  80;ASN A  74;ASP A  57","None","0.85A","5gwxA-3fvqA:2.2","5gwxA-3fvqA:23.26"],["5HS6_A_J3ZA302_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE 14","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"GLN A 282;TYR A 283;LEU A 259;LEU A 262","None","1.13A","5hs6A-3fvqA:undetectable","5hs6A-3fvqA:22.10"],["5IGP_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",5,"VAL A  86;ALA A 147;ALA A 148;VAL A  90;GLY A 142","None","1.42A","5igpA-3fvqA:undetectable","5igpA-3fvqA:23.14"],["5IY5_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"ARG A 208;LEU A  33;PHE A 194;LEU A  27","None","1.19A","5iy5P-3fvqA:undetectable;5iy5W-3fvqA:undetectable","5iy5P-3fvqA:21.10;5iy5W-3fvqA:11.85"],["5XDX_C_CHDC308_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"ARG A 208;LEU A  33;PHE A 194;LEU A  27","None","1.25A","5xdxC-3fvqA:undetectable;5xdxJ-3fvqA:undetectable","5xdxC-3fvqA:21.04;5xdxJ-3fvqA:11.85"],["5XDX_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",4,"ARG A 208;LEU A  33;PHE A 194;LEU A  27","None","1.25A","5xdxP-3fvqA:undetectable;5xdxW-3fvqA:undetectable","5xdxP-3fvqA:21.04;5xdxW-3fvqA:11.85"],["6A5Z_D_9CRD501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","3fvq","FE(3+) IONS IMPORT ATP-BINDING PROTEIN FBPC","Neisseria gonorrhoeae",5,"ILE A   7;ILE A  35;LEU A   5;ILE A 217;LEU A  20","None","1.16A","6a5zD-3fvqA:undetectable","6a5zD-3fvqA:16.19"]]