SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 8 THR A 272
GLY A 184
ALA A 280
ILE A 188
 None
 0.81A 1c9sI-3fvrA:
undetectable
1c9sJ-3fvrA:
undetectable		 1c9sI-3fvrA:
14.60
1c9sJ-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 GLY A 184
ALA A 280
ILE A 188
THR A 272
 None
 0.80A 1gtnA-3fvrA:
undetectable
1gtnK-3fvrA:
undetectable		 1gtnA-3fvrA:
14.60
1gtnK-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 8 THR A 272
GLY A 184
ALA A 280
ILE A 188
 None
 0.79A 1gtnA-3fvrA:
undetectable
1gtnB-3fvrA:
undetectable		 1gtnA-3fvrA:
14.60
1gtnB-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 8 THR A 272
GLY A 184
ALA A 280
ILE A 188
 None
 0.79A 1gtnE-3fvrA:
undetectable
1gtnF-3fvrA:
undetectable		 1gtnE-3fvrA:
14.60
1gtnF-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 11 PHE A 278
ALA A 280
ALA A 191
ALA A 190
LEU A 250
 None
 1.05A 1jinA-3fvrA:
undetectable		 1jinA-3fvrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		3 / 3 TRP A 256
PHE A  24
TRP A  28
 None
 1.36A 1r15C-3fvrA:
undetectable		 1r15C-3fvrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		3 / 3 TRP A 256
PHE A  24
TRP A  28
 None
 1.37A 1r15F-3fvrA:
undetectable		 1r15F-3fvrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		3 / 3 TRP A 256
PHE A  24
TRP A  28
 None
 1.36A 1r15G-3fvrA:
undetectable		 1r15G-3fvrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		3 / 3 TRP A 256
PHE A  24
TRP A  28
 None
 1.37A 1r15H-3fvrA:
undetectable		 1r15H-3fvrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 11 GLY A 183
ALA A 187
LEU A 250
VAL A 201
VAL A 200
 None
 1.11A 1ukbA-3fvrA:
17.0		 1ukbA-3fvrA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 8 GLY A 184
ALA A 280
ILE A 188
THR A 272
 None
 0.81A 1utdF-3fvrA:
undetectable
1utdG-3fvrA:
undetectable		 1utdF-3fvrA:
14.60
1utdG-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 9 LEU A 161
HIS A  82
ALA A  84
TYR A 110
LEU A 316
 None
 1.39A 2azqA-3fvrA:
undetectable		 2azqA-3fvrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 8 ASP A 249
SER A 208
TYR A  14
HIS A 283
 None
 1.38A 2bteD-3fvrA:
undetectable		 2bteD-3fvrA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 11 LEU A 253
ALA A 157
LEU A 161
SER A 194
LEU A 193
 None
 1.34A 2c12F-3fvrA:
undetectable		 2c12F-3fvrA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 12 TYR A  49
VAL A  51
ASN A 104
GLY A  98
ILE A  99
 None
 1.34A 2dcfA-3fvrA:
undetectable		 2dcfA-3fvrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 PRO A 197
LEU A 161
ALA A 157
PHE A  88
 None
 0.95A 2vcvA-3fvrA:
undetectable		 2vcvA-3fvrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 PRO A 197
LEU A 161
ALA A 157
PHE A  88
 None
 1.02A 2vcvG-3fvrA:
undetectable		 2vcvG-3fvrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 PRO A 197
ALA A 190
ALA A 160
PHE A 113
 None
 1.02A 2vcvL-3fvrA:
undetectable		 2vcvL-3fvrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 PRO A 197
LEU A 161
ALA A 157
PHE A  88
 None
 0.92A 2vcvL-3fvrA:
undetectable		 2vcvL-3fvrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 9 TYR A 150
THR A 244
TYR A 222
LEU A 253
LEU A 250
 None
 1.28A 2zb8A-3fvrA:
2.4		 2zb8A-3fvrA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 12 GLY A 152
TYR A 148
TYR A 247
TYR A 150
SER A  67
 None
 1.50A 2zthA-3fvrA:
2.6		 2zthA-3fvrA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 12 TYR A  49
VAL A  51
ASN A 104
GLY A  98
ILE A  99
 None
 1.33A 3a65A-3fvrA:
undetectable		 3a65A-3fvrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 11 LEU A 284
ALA A 254
LEU A 250
ALA A 202
VAL A 200
 None
 0.93A 3e22B-3fvrA:
2.9		 3e22B-3fvrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 11 LEU A 284
ALA A 254
LEU A 250
ALA A 202
VAL A 200
 None
 0.94A 3e22D-3fvrA:
3.4		 3e22D-3fvrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 ASP A 249
SER A 208
TYR A  14
HIS A 283
 None
 1.29A 4arcA-3fvrA:
undetectable		 4arcA-3fvrA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 6 THR A 244
THR A 129
HIS A 133
ASN A 232
 None
 1.31A 4pfjB-3fvrA:
3.9		 4pfjB-3fvrA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 5 THR A 244
THR A 129
HIS A 133
ASN A 232
 None
 1.35A 4pgfB-3fvrA:
4.5		 4pgfB-3fvrA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 6 GLU A 169
TYR A  73
LEU A  59
PHE A 167
 None
 1.18A 4twdI-3fvrA:
undetectable
4twdJ-3fvrA:
undetectable		 4twdI-3fvrA:
24.15
4twdJ-3fvrA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		4 / 7 GLU A 243
PHE A 248
LYS A 145
TYR A 148
 None
 1.45A 4uciB-3fvrA:
undetectable		 4uciB-3fvrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		3 / 3 ASP A  77
VAL A  51
LEU A 107
 None
 0.65A 5e5jB-3fvrA:
undetectable		 5e5jB-3fvrA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 12 THR A 126
SER A  67
VAL A  38
ARG A 151
GLU A  34
 None
 1.37A 5v1tA-3fvrA:
undetectable		 5v1tA-3fvrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3fvr ACETYL XYLAN
ESTERASE
(Bacillus
pumilus) 		5 / 12 VAL A 277
THR A 272
LEU A 290
VAL A 292
GLY A 266
 None
 1.07A 6a94B-3fvrA:
undetectable		 6a94B-3fvrA:
22.25