SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		5 / 11 LEU A 108
LEU A 178
MET A 140
LEU A 135
VAL A  65
 None
 1.28A 1ee2A-3fvwA:
3.4		 1ee2A-3fvwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		5 / 11 LEU A 108
LEU A 178
MET A 140
LEU A 135
VAL A  65
 None
 1.26A 1ee2B-3fvwA:
3.5		 1ee2B-3fvwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		5 / 12 ILE A  82
VAL A 107
LEU A  90
LEU A   6
ILE A   8
 None
 1.16A 1kqwA-3fvwA:
undetectable		 1kqwA-3fvwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		6 / 10 LEU A  89
PHE A  46
VAL A  86
GLY A  84
LEU A  93
SER A  94
 None
 1.29A 2v3kA-3fvwA:
undetectable		 2v3kA-3fvwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		4 / 7 ASP A  91
PHE A  46
ASN A  88
PHE A  45
 None
 1.25A 2v7uB-3fvwA:
undetectable		 2v7uB-3fvwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		3 / 3 PHE A  46
ASN A  88
PHE A  45
 None
 1.03A 2zbuD-3fvwA:
3.1		 2zbuD-3fvwA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		5 / 9 ALA A 175
ILE A  29
VAL A  35
ALA A  70
ILE A   5
 None
 1.07A 4lbgB-3fvwA:
undetectable		 4lbgB-3fvwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		5 / 12 VAL A 143
ASP A 144
ASP A 110
HIS A 141
ALA A 181
 None
 1.33A 5hnzB-3fvwA:
undetectable		 5hnzB-3fvwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE
(Streptococcus
mutans) 		3 / 3 GLY A 148
GLN A 174
LYS A 167
 None
 0.93A 5imsB-3fvwA:
2.2		 5imsB-3fvwA:
15.21