SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 ASP A 638
LEU A 694
LEU A 692
 CA  A 823 ( 4.6A)
None
None
 0.73A 1ikeA-3fw0A:
undetectable		 1ikeA-3fw0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 744
ALA A 693
LEU A 694
PRO A 696
ILE A 740
 None
 1.21A 1mx8A-3fw0A:
undetectable		 1mx8A-3fw0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 ASP A 638
LEU A 694
LEU A 692
 CA  A 823 ( 4.6A)
None
None
 0.77A 1np1B-3fw0A:
undetectable		 1np1B-3fw0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 10 ALA A 640
THR A 598
HIS A 585
HIS A 786
HIS A 690
 None
None
HG  A 821 (-3.4A)
HG  A 821 ( 3.5A)
HG  A 821 (-3.6A)
 1.23A 1r55A-3fw0A:
undetectable		 1r55A-3fw0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 PHE A 531
GLN A 516
ASN A 804
ASN A 733
 None
HH3  A   1 ( 4.7A)
None
None
 1.26A 2nyrA-3fw0A:
undetectable		 2nyrA-3fw0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 LEU A 512
VAL A 806
ILE A 530
ILE A 572
 None
 0.78A 2piwA-3fw0A:
undetectable		 2piwA-3fw0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 5 PHE A 662
PHE A 606
PHE A 633
ILE A 562
 None
 1.35A 2v0mD-3fw0A:
undetectable		 2v0mD-3fw0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 4 PRO A 610
TYR A 595
GLY A 593
THR A 591
 None
 1.50A 3ib0A-3fw0A:
undetectable		 3ib0A-3fw0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 10 ASP A 652
VAL A 660
GLY A 621
ILE A 619
VAL A 648
 None
 1.08A 4dqcA-3fw0A:
undetectable		 4dqcA-3fw0A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 ARG A 706
TYR A 654
ASP A 800
ARG A 533
 HH3  A   1 (-3.2A)
HH3  A   1 ( 3.9A)
None
HH3  A   1 (-2.7A)
 1.30A 4kr4C-3fw0A:
undetectable		 4kr4C-3fw0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 PRO A 514
SER A 518
PHE A 531
ASP A 560
LEU A 563
 None
 1.45A 5ef8B-3fw0A:
undetectable		 5ef8B-3fw0A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 9 SER A 628
PRO A 626
PHE A 547
SER A 657
ASN A 656
 None
 1.46A 5l1fB-3fw0A:
undetectable		 5l1fB-3fw0A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 PHE A 581
ASN A 579
ARG A 533
GLY A 534
 None
None
HH3  A   1 (-2.7A)
None
 0.82A 5o4yA-3fw0A:
undetectable		 5o4yA-3fw0A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 GLY A 673
PHE A 686
VAL A 605
PRO A 636
GLY A 653
 None
 1.13A 5tuiB-3fw0A:
undetectable		 5tuiB-3fw0A:
23.31