SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DTL_A_BEPA204_1 (CARDIAC TROPONIN C)	3fwb	CELL DIVISION CONTROL PROTEIN 31 (Saccharomyces cerevisiae)	5 / 11	PHE A 105 ILE A 113 LEU A 118 LEU A 125 MET A 137	None	0.34A	1dtlA-3fwbA: 11.5	1dtlA-3fwbA: 30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LXF_C_BEPC92_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3fwb	CELL DIVISION CONTROL PROTEIN 31 (Saccharomyces cerevisiae)	6 / 12	PHE A 105 ILE A 113 LEU A 118 LEU A 125 MET A 137 ILE A 138	None	0.86A	1lxfC-3fwbA: 7.7	1lxfC-3fwbA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RJD_A_TFPA203_1 (CALMODULIN)	3fwb	CELL DIVISION CONTROL PROTEIN 31 (Saccharomyces cerevisiae)	4 / 8	PHE A 105 ILE A 113 LEU A 118 MET A 137	None	0.42A	4rjdA-3fwbA: 13.0	4rjdA-3fwbA: 26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Y_D_9CRD501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3fwb	CELL DIVISION CONTROL PROTEIN 31 (Saccharomyces cerevisiae)	5 / 12	ILE A 25 ALA A 28 LEU A 52 ALA A 51 ILE A 83	None	0.97A	6a5yD-3fwbA: undetectable	6a5yD-3fwbA: 20.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DTL_A_BEPA204_1","CARDIAC TROPONIN C","3fwb","CELL DIVISION CONTROL PROTEIN 31","Saccharomyces cerevisiae",5,"PHE A 105;ILE A 113;LEU A 118;LEU A 125;MET A 137","None","0.34A","1dtlA-3fwbA:11.5","1dtlA-3fwbA:30.00"],["1LXF_C_BEPC92_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","3fwb","CELL DIVISION CONTROL PROTEIN 31","Saccharomyces cerevisiae",6,"PHE A 105;ILE A 113;LEU A 118;LEU A 125;MET A 137;ILE A 138","None","0.86A","1lxfC-3fwbA:7.7","1lxfC-3fwbA:24.10"],["4RJD_A_TFPA203_1","CALMODULIN","3fwb","CELL DIVISION CONTROL PROTEIN 31","Saccharomyces cerevisiae",4,"PHE A 105;ILE A 113;LEU A 118;MET A 137","None","0.42A","4rjdA-3fwbA:13.0","4rjdA-3fwbA:26.76"],["6A5Y_D_9CRD501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","3fwb","CELL DIVISION CONTROL PROTEIN 31","Saccharomyces cerevisiae",5,"ILE A  25;ALA A  28;LEU A  52;ALA A  51;ILE A  83","None","0.97A","6a5yD-3fwbA:undetectable","6a5yD-3fwbA:20.75"]]