SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN
(Leishmania
major) 		4 / 8 SER A  -2
THR A  77
MET A  76
LEU A  31
 None
 1.02A 1lhvA-3fwtA:
undetectable		 1lhvA-3fwtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN
(Leishmania
major) 		4 / 6 PHE A  42
TYR A  23
THR A   5
VAL A   7
 None
 1.25A 3lb3A-3fwtA:
undetectable		 3lb3A-3fwtA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN
(Leishmania
major) 		3 / 3 THR A  40
SER A  20
ASP A  13
 None
 0.83A 5kvaA-3fwtA:
undetectable		 5kvaA-3fwtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN
(Leishmania
major) 		3 / 3 THR A  40
SER A  20
ASP A  13
 None
 0.82A 5kvaB-3fwtA:
undetectable		 5kvaB-3fwtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN
(Leishmania
major) 		5 / 12 GLU A  29
LEU A  19
ALA A  22
THR A  85
ARG A  79
 None
 1.18A 5nd3B-3fwtA:
undetectable		 5nd3B-3fwtA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN
(Leishmania
major) 		4 / 6 ILE A  80
TYR A  23
LEU A   3
VAL A  97
 None
 1.29A 6f6jA-3fwtA:
undetectable		 6f6jA-3fwtA:
undetectable