SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 9 THR A  65
LEU A  27
VAL A  26
ASP A  68
ILE A  40
 None
 1.39A 1gebA-3fwwA:
undetectable		 1gebA-3fwwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		4 / 8 ALA A 336
LEU A 315
ALA A 330
THR A 313
 None
 0.87A 1ie4B-3fwwA:
undetectable
1ie4D-3fwwA:
undetectable		 1ie4B-3fwwA:
16.21
1ie4D-3fwwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 9 THR A 170
GLY A 171
LEU A 102
LEU A 118
THR A 113
 None
 1.22A 2npnA-3fwwA:
undetectable		 2npnA-3fwwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		4 / 5 ARG A 237
ASP A 261
ILE A 279
GLU A 236
 None
 1.35A 2xrzA-3fwwA:
undetectable
2xrzB-3fwwA:
undetectable		 2xrzA-3fwwA:
22.70
2xrzB-3fwwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 MET A  86
GLN A  76
ALA A  12
PHE A  93
GLY A  56
 None
 1.43A 3aobC-3fwwA:
undetectable		 3aobC-3fwwA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 ALA A 330
LEU A 298
ILE A 309
THR A 313
ILE A 272
 None
 1.01A 3gcsA-3fwwA:
undetectable		 3gcsA-3fwwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 THR A 170
THR A 130
GLU A 167
LEU A 173
ILE A 202
 None
 1.23A 3gwxB-3fwwA:
undetectable		 3gwxB-3fwwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 11 GLY A 225
GLU A 224
ARG A 237
LEU A 232
LEU A 108
 None
 1.27A 3ndvA-3fwwA:
undetectable
3ndvB-3fwwA:
undetectable		 3ndvA-3fwwA:
24.22
3ndvB-3fwwA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		3 / 3 GLU A 236
LEU A  30
LEU A  23
 None
 0.71A 3ohtA-3fwwA:
undetectable		 3ohtA-3fwwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		3 / 3 GLU A 236
LEU A  30
LEU A  23
 None
 0.69A 3ohtB-3fwwA:
undetectable		 3ohtB-3fwwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 9 ILE A 109
GLN A 115
LEU A 114
VAL A 215
LEU A 129
 None
 1.21A 4g1bC-3fwwA:
2.2		 4g1bC-3fwwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		4 / 5 LEU A 186
TRP A 183
ILE A 126
ASN A 169
 None
 1.41A 4i00A-3fwwA:
undetectable		 4i00A-3fwwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.84A 4o2bD-3fwwA:
undetectable		 4o2bD-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.96A 4o2bD-3fwwA:
undetectable		 4o2bD-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		3 / 3 PRO A 122
VAL A 215
HIS A 216
 None
 0.81A 4pevC-3fwwA:
2.6		 4pevC-3fwwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 332
ALA A 336
LEU A 355
THR A 382
ALA A 330
 None
 1.27A 4x1iB-3fwwA:
undetectable		 4x1iB-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 1.02A 4x20B-3fwwA:
undetectable		 4x20B-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 1.01A 4x20B-3fwwA:
undetectable		 4x20B-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 VAL A 131
LEU A 114
LEU A 102
ILE A 172
VAL A 106
 None
 0.96A 4y0sA-3fwwA:
undetectable		 4y0sA-3fwwA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		3 / 3 TYR A 197
THR A  82
THR A 199
 None
 0.79A 5aoxB-3fwwA:
undetectable		 5aoxB-3fwwA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		3 / 3 TYR A 197
THR A  82
THR A 199
 None
 0.77A 5aoxE-3fwwA:
undetectable		 5aoxE-3fwwA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.92A 5eypB-3fwwA:
undetectable		 5eypB-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		4 / 8 VAL A 401
ILE A 378
ALA A 370
THR A 395
 None
 0.72A 5og9A-3fwwA:
undetectable		 5og9A-3fwwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 GLY A  14
GLY A  83
GLY A  81
GLU A 195
ILE A 198
 None
 0.93A 5wz2C-3fwwA:
undetectable		 5wz2C-3fwwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3fww BIFUNCTIONAL PROTEIN
GLMU
(Yersinia
pestis) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.96A 5xiwB-3fwwA:
undetectable		 5xiwB-3fwwA:
15.24