SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		5 / 9 VAL A 154
LEU A 155
VAL A 159
GLY A 161
ALA A 164
 None
 1.29A 1pxxB-3fwyA:
undetectable		 1pxxB-3fwyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 SER A  49
LEU A  77
SER A  48
ASP A 153
GLU A 116
 None
None
None
MG  A 401 ( 4.0A)
None
 1.30A 2j1gE-3fwyA:
undetectable
2j1gF-3fwyA:
undetectable		 2j1gE-3fwyA:
20.07
2j1gF-3fwyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 SER A  49
LEU A  77
ASP A 153
GLU A 116
 None
None
MG  A 401 ( 4.0A)
None
 1.17A 2j2pE-3fwyA:
undetectable
2j2pF-3fwyA:
undetectable		 2j2pE-3fwyA:
20.07
2j2pF-3fwyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 SER A  49
SER A  48
ASP A 153
GLU A 116
 None
None
MG  A 401 ( 4.0A)
None
 1.17A 2j2pE-3fwyA:
undetectable
2j2pF-3fwyA:
undetectable		 2j2pE-3fwyA:
20.07
2j2pF-3fwyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A  35
ILE A 190
ASN A 188
LEU A 205
GLY A 207
 None
 1.10A 3nrrA-3fwyA:
undetectable		 3nrrA-3fwyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A  35
ILE A 190
ASN A 188
LEU A 205
GLY A 207
 None
 1.05A 3nrrB-3fwyA:
3.5		 3nrrB-3fwyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 ALA A 262
ILE A 240
LEU A 250
GLU A 265
 None
ADP  A 501 (-3.6A)
None
None
 0.90A 3r9sA-3fwyA:
undetectable		 3r9sA-3fwyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 SER A 183
MET A 187
ASP A  68
 None
None
MG  A 401 ( 4.5A)
 0.93A 4mm4B-3fwyA:
undetectable		 4mm4B-3fwyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
(Rhodobacter
sphaeroides) 		4 / 4 LEU A  51
MET A 234
ILE A  57
LEU A 250
 None
 1.42A 5nfpA-3fwyA:
undetectable		 5nfpA-3fwyA:
20.24