SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 12 GLY A 528
ALA A 529
ILE A 498
ALA A 515
VAL A 532
 None
 1.08A 2b7zA-3fwzA:
undetectable		 2b7zA-3fwzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 12 GLY A 424
GLU A 447
ASN A 467
ALA A 468
LEU A 432
 AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.0A)
AMP  A 601 (-3.9A)
None
 1.08A 3ckkA-3fwzA:
6.8		 3ckkA-3fwzA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 12 GLY A 424
GLU A 447
SER A 449
ALA A 468
ILE A 489
 AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
None
AMP  A 601 (-3.9A)
AMP  A 601 (-3.6A)
 0.78A 3id6C-3fwzA:
7.8		 3id6C-3fwzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		4 / 7 ALA A 482
VAL A 414
VAL A 444
LEU A 421
 None
 0.82A 3o14A-3fwzA:
undetectable		 3o14A-3fwzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 12 ALA A 477
ILE A 498
GLU A 494
VAL A 423
ILE A 489
 None
None
AMP  A 601 (-3.6A)
AMP  A 601 ( 4.9A)
AMP  A 601 (-3.6A)
 1.13A 4aztA-3fwzA:
6.0		 4aztA-3fwzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 12 ILE A 524
GLY A 492
HIS A 516
ALA A 513
ALA A 529
 None
 1.06A 5n0oB-3fwzA:
undetectable		 5n0oB-3fwzA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 12 ILE A 524
GLY A 492
HIS A 516
ALA A 513
ALA A 529
 None
 0.99A 5n0tB-3fwzA:
2.8		 5n0tB-3fwzA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		4 / 7 ARG A 514
ILE A 489
THR A 525
ARG A 537
 AMP  A 601 (-3.0A)
AMP  A 601 (-3.6A)
None
None
 1.02A 5vc0A-3fwzA:
undetectable		 5vc0A-3fwzA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 11 VAL A 423
GLY A 424
GLU A 447
ALA A 468
LEU A 487
 AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.9A)
None
 1.06A 5x6yA-3fwzA:
4.8		 5x6yA-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 10 VAL A 423
GLY A 424
GLU A 447
ALA A 468
LEU A 487
 AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.9A)
None
 1.09A 5x6yB-3fwzA:
4.0		 5x6yB-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 11 VAL A 423
GLY A 424
GLU A 447
ALA A 468
LEU A 487
 AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.9A)
None
 1.23A 5x6yC-3fwzA:
3.1		 5x6yC-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3fwz INNER MEMBRANE
PROTEIN YBAL
(Escherichia
coli) 		5 / 11 VAL A 423
GLY A 424
GLU A 447
SER A 449
ALA A 468
 AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
None
AMP  A 601 (-3.9A)
 0.90A 5x6yC-3fwzA:
3.1		 5x6yC-3fwzA:
11.19