SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  62
SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.95A 1n5xA-3fxaA:
undetectable		 1n5xA-3fxaA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  62
SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.95A 1n5xB-3fxaA:
undetectable		 1n5xB-3fxaA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 10 VAL A 162
LEU A 107
VAL A  49
GLY A  51
SER A  55
 None
 1.19A 1pxxD-3fxaA:
undetectable		 1pxxD-3fxaA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 7 LEU A  24
VAL A  27
THR A  28
VAL A 124
 None
 0.85A 2qblA-3fxaA:
undetectable		 2qblA-3fxaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 ALA A 155
GLU A 147
VAL A 144
LEU A  24
PRO A  25
 None
 1.15A 2qk8A-3fxaA:
undetectable		 2qk8A-3fxaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A  47
ILE A  40
SER A 165
PHE A  66
THR A 120
 None
 1.08A 2w9sC-3fxaA:
undetectable		 2w9sC-3fxaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 8 SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.74A 3ax7A-3fxaA:
undetectable		 3ax7A-3fxaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 8 SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.73A 3ax9A-3fxaA:
undetectable		 3ax9A-3fxaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLU A 147
SER A 143
VAL A  27
 None
 0.83A 3eeoA-3fxaA:
3.6		 3eeoA-3fxaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 5 ILE A  21
THR A  28
PHE A 140
PHE A 166
 None
 1.20A 3em0A-3fxaA:
undetectable		 3em0A-3fxaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 5 PRO A  25
SER A  22
LEU A  33
SER A 165
 None
 1.43A 3ijxH-3fxaA:
undetectable		 3ijxH-3fxaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 5 PRO A  25
SER A  22
LEU A  33
SER A 165
 None
 1.45A 3iluH-3fxaA:
undetectable		 3iluH-3fxaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 173
ILE A  40
LEU A  62
ASN A  67
ILE A  96
 None
 1.02A 3uwlB-3fxaA:
undetectable		 3uwlB-3fxaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		4 / 8 ILE A  40
SER A 119
LEU A  97
ILE A 122
 None
 0.96A 4xtaB-3fxaA:
undetectable		 4xtaB-3fxaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 173
ILE A  40
LEU A  62
ASN A  67
ILE A  96
 None
 0.98A 6qxsB-3fxaA:
undetectable		 6qxsB-3fxaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3fxa SIS DOMAIN PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 173
ILE A  40
LEU A  62
ASN A  67
ILE A  96
 None
 0.98A 6qxsD-3fxaA:
undetectable		 6qxsD-3fxaA:
23.40