SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		5 / 11 HIS A 206
LEU A 138
GLY A 159
PHE A 158
VAL A 132
 None
 1.45A 1axwB-3fxbA:
undetectable		 1axwB-3fxbA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 7 VAL A 284
LEU A 151
PHE A 158
LEU A 138
 None
 0.87A 1j8uA-3fxbA:
undetectable		 1j8uA-3fxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		5 / 11 VAL A 284
PHE A 158
LEU A 138
HIS A 206
GLU A 183
 None
 1.29A 1mmtA-3fxbA:
undetectable		 1mmtA-3fxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		3 / 3 THR A  67
GLU A  73
ASP A 294
 None
 0.87A 1nt2A-3fxbA:
undetectable		 1nt2A-3fxbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 6 TYR A   5
LEU A 116
ASN A 117
ASP A 240
 None
 1.42A 2w98A-3fxbA:
undetectable
2w98B-3fxbA:
undetectable		 2w98A-3fxbA:
23.32
2w98B-3fxbA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 6 ILE A 194
TYR A 190
MET A 264
ILE A 201
 None
 1.10A 3eteA-3fxbA:
undetectable
3eteE-3fxbA:
undetectable		 3eteA-3fxbA:
20.48
3eteE-3fxbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 5 ILE A 194
TYR A 190
MET A 264
ILE A 201
 None
 1.10A 3eteB-3fxbA:
undetectable
3eteC-3fxbA:
undetectable		 3eteB-3fxbA:
20.48
3eteC-3fxbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 7 MET A 264
ILE A 201
ILE A 194
TYR A 190
 None
 1.10A 3eteD-3fxbA:
undetectable
3eteF-3fxbA:
undetectable		 3eteD-3fxbA:
20.48
3eteF-3fxbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 8 ASP A 227
LEU A 230
TRP A   3
ASP A   1
 None
 1.11A 3n2oC-3fxbA:
undetectable
3n2oD-3fxbA:
undetectable		 3n2oC-3fxbA:
18.51
3n2oD-3fxbA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		5 / 12 GLY A  68
GLY A  65
GLN A  62
LEU A 150
ALA A  74
 None
 1.23A 3sxjA-3fxbA:
undetectable		 3sxjA-3fxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		5 / 12 GLY A  68
GLY A  65
GLN A  62
LEU A 150
ALA A  74
 None
 1.23A 3sxjB-3fxbA:
undetectable		 3sxjB-3fxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 8 GLN A 247
GLN A 246
ASN A 208
THR A 210
 None
 1.36A 4d1yA-3fxbA:
undetectable
4d1yB-3fxbA:
undetectable		 4d1yA-3fxbA:
20.69
4d1yB-3fxbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 5 LEU A  90
LEU A  83
MET A 303
THR A 210
 None
 1.40A 4do3A-3fxbA:
2.3		 4do3A-3fxbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 8 LEU A 230
PHE A 219
THR A   2
ASP A   1
 None
 0.97A 4drjB-3fxbA:
undetectable		 4drjB-3fxbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		5 / 12 VAL A 132
VAL A 124
PHE A 277
PHE A 143
LEU A 151
 None
 1.22A 4nc3A-3fxbA:
undetectable		 4nc3A-3fxbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 6 PHE A 277
ASP A 137
LEU A 138
THR A 202
 None
 1.20A 4paeA-3fxbA:
undetectable		 4paeA-3fxbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		4 / 6 ASN A 184
GLU A   9
GLU A   8
PHE A  66
 4CS  A 401 (-3.0A)
4CS  A 401 (-3.7A)
4CS  A 401 ( 4.6A)
4CS  A 401 (-4.4A)
 1.28A 4twdG-3fxbA:
undetectable
4twdH-3fxbA:
undetectable		 4twdG-3fxbA:
23.12
4twdH-3fxbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ruegeria
pomeroyi) 		5 / 12 VAL A 170
SER A 191
ILE A 194
GLU A 183
THR A 127
 None
 1.25A 5w8aA-3fxbA:
undetectable		 5w8aA-3fxbA:
20.86