SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3fxd PROTEIN ICMQ
PROTEIN ICMR
(Legionella
pneumophila) 		5 / 12 GLU B  40
ARG A  45
ILE B  41
ILE A  13
ALA B  83
 None
 1.16A 1kijB-3fxdB:
undetectable		 1kijB-3fxdB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3fxd PROTEIN ICMQ
PROTEIN ICMR
(Legionella
pneumophila) 		4 / 8 VAL B  56
PHE A  31
PRO A  25
TRP A  26
 None
 1.32A 3v35A-3fxdB:
undetectable		 3v35A-3fxdB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3fxd PROTEIN ICMQ
PROTEIN ICMR
(Legionella
pneumophila;
Legionella
pneumophila) 		5 / 9 GLY A  24
ILE A  35
GLY A  36
LEU A  39
ILE B  42
 None
 0.98A 5vkqC-3fxdA:
4.0
5vkqD-3fxdA:
4.0		 5vkqC-3fxdA:
2.94
5vkqD-3fxdA:
2.94