SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 GLN A 343
LEU A 301
LEU A 307
ALA A 314
ILE A 294
 None
 1.01A 2bxcA-3fxgA:
undetectable		 2bxcA-3fxgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 8 GLY A 169
THR A 173
ALA A 174
ALA A 175
 None
 0.38A 2ej3A-3fxgA:
undetectable		 2ej3A-3fxgA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 7 ILE A  37
LEU A 362
PHE A 359
LEU A 346
 None
 0.86A 3adxA-3fxgA:
undetectable		 3adxA-3fxgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 LEU A  67
VAL A  77
GLY A  78
ASP A 141
ILE A 388
 None
 1.19A 3bf1A-3fxgA:
undetectable
3bf1B-3fxgA:
undetectable		 3bf1A-3fxgA:
19.96
3bf1B-3fxgA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 THR A  81
LEU A  67
VAL A  77
GLY A  78
ILE A 388
 None
 1.18A 3bf1A-3fxgA:
undetectable
3bf1B-3fxgA:
undetectable		 3bf1A-3fxgA:
19.96
3bf1B-3fxgA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 4 LEU A 308
ASP A 297
VAL A 321
THR A 340
 None
 1.24A 3cyxB-3fxgA:
undetectable		 3cyxB-3fxgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 SER A 330
GLN A 334
PHE A 333
 None
 0.79A 3g4lC-3fxgA:
undetectable		 3g4lC-3fxgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 PRO A 338
PHE A 333
ALA A 311
 None
 0.63A 3itaD-3fxgA:
0.7		 3itaD-3fxgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 ARG A  55
ASP A 297
GLN A 343
 None
 0.86A 3lcvB-3fxgA:
undetectable		 3lcvB-3fxgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 LYS A 125
ARG A 124
ASP A 256
 None
 1.26A 3o7wA-3fxgA:
undetectable		 3o7wA-3fxgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 5 ASP A 297
GLU A 247
THR A 168
SER A  65
 None
MG  A 501 (-3.2A)
None
None
 1.29A 3p2kC-3fxgA:
undetectable		 3p2kC-3fxgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 ASP A  38
GLY A  33
GLY A  32
SER A  54
THR A  56
 None
 1.04A 3uboB-3fxgA:
undetectable		 3uboB-3fxgA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 5 ARG A 106
LEU A 143
VAL A 146
ASP A 104
 None
 0.61A 3ufnA-3fxgA:
undetectable
3ufnB-3fxgA:
undetectable		 3ufnA-3fxgA:
14.61
3ufnB-3fxgA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 CYH A 190
ASN A 227
LYS A  47
 None
 1.18A 4k50A-3fxgA:
0.0		 4k50A-3fxgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 ASP A 193
TRP A 246
SER A  46
 None
 0.87A 4lrhA-3fxgA:
undetectable		 4lrhA-3fxgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 SER A  46
GLU A 248
GLU A 344
 None
 0.69A 4ymgB-3fxgA:
undetectable		 4ymgB-3fxgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 6 ASP A 164
TYR A 331
PRO A 367
LEU A 379
 None
 1.34A 5bmvB-3fxgA:
undetectable		 5bmvB-3fxgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 ALA A  88
PRO A  86
GLY A  82
GLY A  84
GLY A  64
 None
 0.92A 5c0oH-3fxgA:
undetectable		 5c0oH-3fxgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 GLY A  82
GLY A  24
THR A  81
VAL A 134
ASP A  26
 None
 1.03A 5njvD-3fxgA:
undetectable		 5njvD-3fxgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 8 GLU A 248
THR A  43
PRO A  44
ILE A  60
 None
 1.00A 6a4iA-3fxgA:
undetectable		 6a4iA-3fxgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		3 / 3 ASN A 290
VAL A 235
HIS A 265
 None
 0.72A 6a5yD-3fxgA:
undetectable		 6a5yD-3fxgA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 8 GLY A 126
ILE A 129
ASP A 297
PRO A 296
 None
 0.76A 6ag0A-3fxgA:
7.6		 6ag0A-3fxgA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 9 ALA A 130
VAL A  92
ALA A  88
VAL A  68
GLY A  85
 None
 1.09A 6bklA-3fxgA:
undetectable
6bklB-3fxgA:
undetectable
6bklC-3fxgA:
undetectable
6bklD-3fxgA:
undetectable		 6bklA-3fxgA:
4.13
6bklB-3fxgA:
4.13
6bklC-3fxgA:
4.13
6bklD-3fxgA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		5 / 12 LEU A 110
LEU A  91
VAL A  92
ILE A 135
ASP A 136
 None
 1.07A 6bxmA-3fxgA:
undetectable		 6bxmA-3fxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 6 LEU A 291
TYR A 166
ASP A 221
GLU A 247
 None
None
MG  A 501 (-2.8A)
MG  A 501 (-3.2A)
 1.49A 6djzC-3fxgA:
undetectable		 6djzC-3fxgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3fxg RHAMNONATE
DEHYDRATASE
(Fusarium
graminearum) 		4 / 4 LEU A 143
ASP A 104
PRO A 105
ARG A 106
 None
 1.20A 6fgdA-3fxgA:
undetectable		 6fgdA-3fxgA:
23.35