SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 195
PHE A 165
LEU A 182
LEU A 180
PHE A 171
 None
 1.13A 1dtlA-3fxiA:
undetectable		 1dtlA-3fxiA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 4 THR A 577
LEU A 576
LEU A 564
GLN A 562
 NAG  A 761 (-3.8A)
None
None
None
 1.20A 1fbmA-3fxiA:
undetectable		 1fbmA-3fxiA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 315
GLY A 343
GLY A 363
ILE A 320
LEU A 350
 None
 1.04A 1p91B-3fxiA:
undetectable		 1p91B-3fxiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 7 SER A 368
PHE A 396
PHE A 387
LEU A 434
 None
 1.12A 1qcaA-3fxiA:
undetectable		 1qcaA-3fxiA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 6 LEU A 290
LEU A 315
LEU A 303
LEU A 280
 None
 1.02A 2ab2A-3fxiA:
undetectable		 2ab2A-3fxiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 8 PHE A 532
LEU A 511
LEU A 525
LEU A 549
 None
 0.98A 2bfpA-3fxiA:
undetectable		 2bfpA-3fxiA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
 None
 1.12A 2bxeB-3fxiA:
undetectable		 2bxeB-3fxiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 7 LEU A 519
LEU A 495
ILE A 466
SER A 441
 None
 1.22A 2hc4A-3fxiA:
undetectable		 2hc4A-3fxiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		6 / 12 MET A 243
LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 1.05A 2hrcA-3fxiA:
undetectable		 2hrcA-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.92A 2hrcB-3fxiA:
undetectable		 2hrcB-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 1.06A 2hrcB-3fxiA:
undetectable		 2hrcB-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 310
LEU A 335
PHE A 313
SER A 314
ILE A 300
 None
 1.13A 2oipA-3fxiA:
undetectable		 2oipA-3fxiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 601
LEU A 574
LEU A 549
ILE A 594
LEU A 511
 None
 0.94A 2pnjA-3fxiA:
undetectable		 2pnjA-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		6 / 12 MET A 243
LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 1.17A 2pnjA-3fxiA:
undetectable		 2pnjA-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 MET A 243
LEU A 277
PHE A 304
LEU A 280
VAL A 255
 None
 1.10A 2pnjB-3fxiA:
undetectable		 2pnjB-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.90A 2po5A-3fxiA:
undetectable		 2po5A-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 0.92A 2po5A-3fxiA:
undetectable		 2po5A-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 11 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.95A 2po5B-3fxiA:
undetectable		 2po5B-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 11 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 0.97A 2po5B-3fxiA:
undetectable		 2po5B-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.81A 2po7A-3fxiA:
undetectable		 2po7A-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.84A 2po7B-3fxiA:
undetectable		 2po7B-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 1.00A 2qd4A-3fxiA:
undetectable		 2qd4A-3fxiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.81A 2qd4B-3fxiA:
undetectable		 2qd4B-3fxiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 ILE A  93
PHE A 144
LEU A 107
VAL A 132
LEU A 131
 None
 1.40A 2w98A-3fxiA:
undetectable		 2w98A-3fxiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 8 VAL A 475
SER A 528
TYR A 451
VAL A 524
 None
NAG  A 731 ( 4.1A)
None
None
 0.90A 2y05A-3fxiA:
undetectable
2y05B-3fxiA:
undetectable		 2y05A-3fxiA:
18.57
2y05B-3fxiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 ILE A 146
LEU A 131
ALA A 133
THR A 136
LEU A 117
 None
 1.15A 3a50A-3fxiA:
undetectable		 3a50A-3fxiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 5 SER A  71
LEU A 117
GLY A 120
GLU A  94
 None
 0.98A 3aiaA-3fxiA:
undetectable
3aiaB-3fxiA:
undetectable		 3aiaA-3fxiA:
17.43
3aiaB-3fxiA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 5 LEU A 401
GLN A 393
THR A 398
LEU A 446
 None
 1.23A 3ce6D-3fxiA:
undetectable		 3ce6D-3fxiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 GLY A 261
ILE A 285
LEU A 307
LEU A 250
LEU A 231
 None
 1.16A 3cs8A-3fxiA:
undetectable		 3cs8A-3fxiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 5 PHE A 492
PHE A 483
THR A 459
LEU A 476
 None
 1.05A 3t3zC-3fxiA:
undetectable		 3t3zC-3fxiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		3 / 3 PHE A 263
SER A 183
SER A 211
 None
 0.97A 3ufgB-3fxiA:
undetectable		 3ufgB-3fxiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 7 ILE A 556
SER A 559
PHE A 567
LEU A 564
 None
 0.90A 3v7pA-3fxiA:
undetectable		 3v7pA-3fxiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 6 PRO A 489
LEU A 508
ASN A 486
GLU A 485
 None
 0.83A 3zqtA-3fxiA:
undetectable		 3zqtA-3fxiA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 5 LEU A 473
ILE A 454
MET A 478
PHE A 443
 None
 1.01A 4dc3B-3fxiA:
undetectable		 4dc3B-3fxiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
 None
 0.98A 4o2bB-3fxiA:
undetectable		 4o2bB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 5 GLY A  70
LEU A 101
ILE A  48
LEU A  85
 None
 0.84A 4o8fA-3fxiA:
undetectable		 4o8fA-3fxiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		3 / 3 THR A 459
ASN A 409
PHE A 408
 None
 0.67A 4pd9A-3fxiA:
undetectable		 4pd9A-3fxiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 350
PHE A 330
LEU A 307
LEU A 280
ALA A 276
 None
 1.36A 4rtbA-3fxiA:
undetectable		 4rtbA-3fxiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
 None
 1.08A 4x1yB-3fxiA:
undetectable		 4x1yB-3fxiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 9 THR A 459
ILE A 454
GLY A 480
LEU A 508
LEU A 488
 None
 1.36A 4ze0A-3fxiA:
undetectable		 4ze0A-3fxiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 197
SER A 172
HIS A 179
VAL A 157
LEU A 182
 None
None
NAG  A 721 (-4.1A)
None
None
 1.20A 5ergB-3fxiA:
undetectable		 5ergB-3fxiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 404
SER A 416
GLU A 369
PHE A 396
GLY A 397
 None
 1.35A 5il1A-3fxiA:
undetectable		 5il1A-3fxiA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 231
LEU A 180
LEU A 210
ASN A 185
ILE A 190
 None
 1.11A 5itzB-3fxiA:
undetectable		 5itzB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
 None
 1.01A 5itzB-3fxiA:
undetectable		 5itzB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
 None
 1.00A 5mioB-3fxiA:
undetectable		 5mioB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 SER A 445
GLU A 425
LEU A 424
GLU A 422
LEU A 421
 None
 0.95A 5nwvA-3fxiA:
undetectable		 5nwvA-3fxiA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		3 / 3 CYH A 246
MET A 215
ASN A 216
 None
 1.30A 5qh8A-3fxiA:
undetectable		 5qh8A-3fxiA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		3 / 3 ARG A 355
PHE A 330
LEU A 372
 None
 0.86A 5veuA-3fxiA:
undetectable		 5veuA-3fxiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		3 / 3 TYR A 451
ASP A 405
ASP A 453
 None
 0.62A 5x6yA-3fxiA:
undetectable		 5x6yA-3fxiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 4 PHE A 326
LEU A 380
LEU A 337
VAL A 370
 None
 1.06A 5xxiA-3fxiA:
undetectable		 5xxiA-3fxiA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 12 CYH A 246
PHE A 237
MET A 215
LEU A 260
LEU A 283
 None
 1.42A 5y2oA-3fxiA:
undetectable		 5y2oA-3fxiA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 LEU A 307
ILE A 247
LEU A 250
PHE A 223
LEU A 228
 None
 1.22A 5y7pB-3fxiA:
undetectable		 5y7pB-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.23A 5y7pB-3fxiA:
undetectable		 5y7pB-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.23A 5y7pD-3fxiA:
undetectable		 5y7pD-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 LEU A 307
ILE A 247
LEU A 250
PHE A 223
LEU A 228
 None
 1.20A 5y7pH-3fxiA:
undetectable		 5y7pH-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		5 / 10 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.21A 5y7pH-3fxiA:
undetectable		 5y7pH-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 5 HIS A 148
ALA A 121
SER A 123
GLY A 124
 None
 1.29A 5yodB-3fxiA:
undetectable		 5yodB-3fxiA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens) 		4 / 7 ALA A  97
ILE A 108
PHE A 122
LEU A 107
 None
 0.87A 6b5vA-3fxiA:
undetectable
6b5vB-3fxiA:
undetectable		 6b5vA-3fxiA:
7.63
6b5vB-3fxiA:
7.63