SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fxq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		4 / 6 PRO A 177
MET A 178
ALA A 181
GLU A 186
 None
BME  A1003 ( 4.8A)
None
None
 1.42A 1qhyA-3fxqA:
undetectable		 1qhyA-3fxqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		4 / 4 LEU A 111
ILE A 291
ILE A 102
ALA A 103
 None
 0.82A 2i30A-3fxqA:
undetectable		 2i30A-3fxqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		4 / 6 TYR A 130
THR A 147
ALA A 145
PRO A 198
 None
None
None
CL  A4002 (-3.7A)
 1.34A 2ql8A-3fxqA:
undetectable
2ql8B-3fxqA:
undetectable		 2ql8A-3fxqA:
19.31
2ql8B-3fxqA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		8 / 8 HIS A 150
ARG A 199
ALA A 203
ILE A 204
ASN A 207
ARG A 211
PRO A 266
PRO A 268
 CL  A4002 (-4.2A)
None
CL  A4002 ( 4.0A)
FMT  A3001 (-4.1A)
None
None
None
None
 0.54A 3fxrA-3fxqA:
35.9		 3fxrA-3fxqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		5 / 8 HIS A 150
ARG A 199
ALA A 203
ILE A 204
PRO A 268
 CL  A4002 (-4.2A)
None
CL  A4002 ( 4.0A)
FMT  A3001 (-4.1A)
None
 1.50A 3fxrA-3fxqA:
35.9		 3fxrA-3fxqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		4 / 6 LEU A  19
SER A  18
ARG A  20
LEU A  49
 None
 1.07A 3ravA-3fxqA:
undetectable		 3ravA-3fxqA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		5 / 12 LEU A 265
ILE A 170
LEU A 239
ILE A 259
PHE A 209
 None
 0.88A 4y0rA-3fxqA:
undetectable		 4y0rA-3fxqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		4 / 9 ILE A  94
PHE A  96
VAL A 280
ILE A 288
 None
 0.98A 5lg3I-3fxqA:
undetectable		 5lg3I-3fxqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		5 / 12 ILE A 270
ILE A  94
LEU A 111
PHE A 118
VAL A 123
 None
 0.93A 5mueA-3fxqA:
undetectable		 5mueA-3fxqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3fxq LYSR TYPE REGULATOR
OF TSAMBCD
(Comamonas
testosteroni) 		5 / 12 ILE A 270
ILE A  94
LEU A 111
PHE A 118
VAL A 123
 None
 0.93A 5mugA-3fxqA:
undetectable		 5mugA-3fxqA:
18.83