SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2
(Xenopus
laevis) 		5 / 12 ALA A 294
LEU A 265
ILE A 267
ILE A 286
LEU A 336
 None
 0.99A 1xdkF-3fy5A:
undetectable		 1xdkF-3fy5A:
11.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2
(Xenopus
laevis) 		6 / 11 PHE A 264
LEU A 265
GLY A 266
ILE A 267
SER A 268
ILE A 269
 None
 0.66A 2kawA-3fy5A:
15.3		 2kawA-3fy5A:
85.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2
(Xenopus
laevis) 		6 / 11 PHE A 264
LEU A 265
GLY A 266
ILE A 267
SER A 268
VAL A 328
 None
 0.67A 2kawA-3fy5A:
15.3		 2kawA-3fy5A:
85.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2
(Xenopus
laevis) 		5 / 9 VAL A 307
ALA A 320
ARG A 325
ILE A 269
ILE A 281
 None
 1.21A 4oknB-3fy5A:
undetectable		 4oknB-3fy5A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2
(Xenopus
laevis) 		5 / 12 GLY A 296
VAL A 255
ILE A 283
GLY A 290
ILE A 267
 None
 0.94A 5kb6B-3fy5A:
undetectable		 5kb6B-3fy5A:
13.37