SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  38
GLY A  40
GLU A  59
LEU A  64
ASP A  84
None
0.85A 1jg3A-3fydA:
10.8
1jg3A-3fydA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  38
GLY A  40
GLU A  59
LEU A  64
ASP A  84
None
0.83A 1jg3B-3fydA:
10.9
1jg3B-3fydA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 8 GLU A  36
GLY A  38
GLU A  59
LEU A  64
ASP A  84
None
0.58A 1jg4A-3fydA:
11.1
1jg4A-3fydA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
4 / 7 VAL A  98
LEU A 124
LEU A  44
VAL A  57
None
0.87A 1jgsA-3fydA:
undetectable
1jgsA-3fydA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
11 / 12 PHE A  12
GLU A  36
GLY A  38
GLY A  40
ILE A  60
ASP A  61
LEU A  64
ASP A  84
ASN A 101
PRO A 103
ILE A 106
None
1.03A 1qaoA-3fydA:
23.2
1qaoA-3fydA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
10 / 12 PHE A  12
GLU A  36
GLY A  38
GLY A  40
ILE A  60
ASP A  61
LEU A  64
ILE A  58
ASN A 101
PRO A 103
None
1.09A 1qaoA-3fydA:
23.2
1qaoA-3fydA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  42
ILE A  60
ASP A  61
ASP A  84
PRO A 103
None
0.71A 1sqfA-3fydA:
11.5
1sqfA-3fydA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
4 / 4 SER A 107
ILE A 110
VAL A  98
THR A  45
None
1.01A 1u70A-3fydA:
undetectable
1u70A-3fydA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
7 / 12 GLY A  40
LEU A  64
ASP A  84
PRO A 103
ILE A 106
MET A 125
SER A 175
None
0.91A 1zq9A-3fydA:
27.9
1zq9A-3fydA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
3 / 3 GLY A  38
GLU A  59
ASN A 101
None
0.64A 1zq9A-3fydA:
27.9
1zq9A-3fydA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
7 / 12 GLY A  38
GLY A  40
LEU A  64
ASP A  84
ASN A 101
ILE A 106
PHE A 167
None
0.75A 1zq9B-3fydA:
28.0
1zq9B-3fydA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
7 / 12 GLY A  40
LEU A  64
ASP A  84
ASN A 101
PRO A 103
ILE A 106
PHE A 167
None
1.04A 1zq9B-3fydA:
28.0
1zq9B-3fydA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 11 GLU A  36
GLU A  59
ILE A  60
ASP A  61
ASP A  84
PRO A 103
None
0.50A 2admA-3fydA:
13.2
2admA-3fydA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLU A  36
GLU A  59
ILE A  60
ASP A  84
PRO A 103
None
0.52A 2admB-3fydA:
13.2
2admB-3fydA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 12 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
ASN A 101
None
0.88A 2nxeA-3fydA:
14.3
2nxeA-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 12 GLY A  40
LEU A 124
GLY A  38
LEU A  44
ILE A 110
ASN A 101
None
1.38A 2nxeA-3fydA:
14.3
2nxeA-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
ILE A  60
ASP A  61
ASN A 101
None
0.70A 2nxeB-3fydA:
14.3
2nxeB-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
None
0.86A 2nxeB-3fydA:
14.3
2nxeB-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
ILE A  60
ASP A  61
ASN A 101
None
0.71A 2zbpA-3fydA:
14.0
2zbpA-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
None
0.84A 2zbpA-3fydA:
14.0
2zbpA-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
LEU A  44
ASN A 101
PRO A 103
None
0.83A 2zulA-3fydA:
13.2
2zulA-3fydA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
4 / 6 GLY A  38
ILE A  58
GLU A  59
ILE A  60
None
0.56A 3a7eA-3fydA:
13.4
3a7eA-3fydA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 ILE A  37
GLY A  38
ILE A  60
ASP A  61
ASP A  84
None
0.65A 3bwcA-3fydA:
11.1
3bwcA-3fydA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
ILE A  60
ASP A  61
ASN A 101
None
0.78A 3cjtG-3fydA:
14.3
3cjtG-3fydA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
None
0.83A 3cjtG-3fydA:
14.3
3cjtG-3fydA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 12 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
ASN A 101
None
0.89A 3cjtO-3fydA:
14.3
3cjtO-3fydA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
LEU A  44
ASN A 101
PRO A 103
None
0.79A 3dmhA-3fydA:
11.4
3dmhA-3fydA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 11 GLU A  36
GLY A  38
GLY A  40
ILE A  58
ASP A  84
ALA A  85
None
0.86A 3dxyA-3fydA:
10.5
3dxyA-3fydA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 11 GLU A  36
GLY A  38
ILE A  58
GLU A  59
ASP A  84
ALA A  85
None
0.50A 3dxyA-3fydA:
10.5
3dxyA-3fydA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
8 / 12 GLY A  38
GLY A  40
GLU A  59
ASP A  61
ASP A  84
ALA A  85
PRO A 103
ILE A 106
None
0.60A 3fuuA-3fydA:
26.8
3fuuA-3fydA:
28.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
11 / 11 GLY A  38
GLY A  40
GLU A  59
ILE A  60
ASP A  61
LEU A  64
ASP A  84
ALA A  85
ASN A 101
PRO A 103
ILE A 106
None
0.33A 3grvA-3fydA:
41.7
3grvA-3fydA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
12 / 12 LEU A  13
GLU A  36
GLY A  38
GLY A  40
GLU A  59
ILE A  60
ASP A  61
LEU A  64
ASP A  84
ALA A  85
ASN A 101
PRO A 103
None
0.35A 3gryA-3fydA:
40.6
3gryA-3fydA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
8 / 12 LEU A  44
GLY A  40
GLU A  59
ILE A  60
ASP A  61
LEU A  64
ASP A  84
PRO A 103
None
1.49A 3gryA-3fydA:
40.6
3gryA-3fydA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  38
GLU A  59
ASP A  84
ALA A  85
ILE A  37
None
1.36A 3id5B-3fydA:
14.5
3id5B-3fydA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  38
THR A  45
GLU A  59
ASP A  84
ALA A  85
None
1.37A 3id5B-3fydA:
14.5
3id5B-3fydA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  38
GLU A  59
ASP A  84
ALA A  85
ILE A  37
None
1.36A 3id5F-3fydA:
14.5
3id5F-3fydA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  38
THR A  45
GLU A  59
ASP A  84
ALA A  85
None
1.37A 3id5F-3fydA:
14.5
3id5F-3fydA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
3 / 3 GLU A  36
LEU A  48
LEU A  74
None
0.59A 3ohtA-3fydA:
undetectable
3ohtA-3fydA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
3 / 3 GLU A  36
LEU A  48
LEU A  74
None
0.61A 3ohtB-3fydA:
undetectable
3ohtB-3fydA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 11 GLY A  40
ASP A  61
ASN A 101
PRO A 103
TYR A 104
None
0.87A 3v8vB-3fydA:
11.5
3v8vB-3fydA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
3 / 3 GLU A  59
ASP A  61
ASP A  84
None
0.27A 4gc9A-3fydA:
26.0
4gc9A-3fydA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
GLY A  40
ASP A  84
ALA A  85
ILE A 106
None
0.85A 4krhA-3fydA:
8.6
4krhA-3fydA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
4 / 6 ASN A  69
ILE A  78
ILE A  80
VAL A  57
None
1.00A 4olmA-3fydA:
undetectable
4olmA-3fydA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 LYS A  50
LEU A  48
ASN A  51
ALA A  26
ALA A  22
None
1.22A 4x1iB-3fydA:
undetectable
4x1iB-3fydA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
3 / 3 TYR A 143
TYR A 187
GLN A 151
None
1.13A 5jsdA-3fydA:
undetectable
5jsdB-3fydA:
undetectable
5jsdA-3fydA:
16.11
5jsdB-3fydA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
3 / 3 TYR A 143
TYR A 187
GLN A 151
None
1.13A 5jsdB-3fydA:
undetectable
5jsdC-3fydA:
undetectable
5jsdB-3fydA:
16.11
5jsdC-3fydA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
4 / 7 GLY A  38
GLU A  59
ASP A  84
ASN A 101
None
0.74A 5mvsA-3fydA:
3.3
5mvsA-3fydA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
4 / 8 GLY A  38
GLU A  59
ASP A  84
ASN A 101
None
0.73A 5mvsB-3fydA:
10.6
5mvsB-3fydA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 9 LEU A  90
VAL A  98
LEU A  35
ILE A 106
ALA A 100
None
1.09A 5og9A-3fydA:
undetectable
5og9A-3fydA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 LEU A  90
VAL A  98
LEU A  35
ILE A 106
ALA A 100
None
1.11A 5og9B-3fydA:
undetectable
5og9B-3fydA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 LEU A  44
PHE A 167
ALA A 166
ALA A 160
ILE A 158
None
0.91A 5veuB-3fydA:
undetectable
5veuB-3fydA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
ILE A  60
ASP A  61
ASP A  84
ALA A  85
None
0.77A 6bq4A-3fydA:
12.2
6bq4A-3fydA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
5 / 12 GLY A  38
ILE A  60
ASP A  61
ASP A  84
ALA A  85
None
0.80A 6bq4B-3fydA:
12.0
6bq4B-3fydA:
13.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
6 / 12 LEU A  44
ILE A  58
GLY A  40
ILE A  60
ASP A  61
LEU A  64
None
1.33A 6iftA-3fydA:
28.7
6iftA-3fydA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
9 / 12 PHE A  12
GLU A  36
ILE A  37
GLY A  38
GLY A  40
ILE A  60
ASP A  61
LEU A  64
PRO A 103
None
0.57A 6iftA-3fydA:
28.7
6iftA-3fydA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococc
us
jannaschii)
7 / 12 PHE A  12
LEU A  13
GLU A  36
GLY A  38
ILE A  60
ASP A  61
LEU A  64
None
0.61A 6iftA-3fydA:
28.7
6iftA-3fydA:
37.87