SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		5 / 11 ALA A  56
LEU A  96
ALA A 100
LEU A   1
THR A 103
 None
 1.26A 1tz8A-3fynA:
undetectable
1tz8B-3fynA:
undetectable		 1tz8A-3fynA:
20.11
1tz8B-3fynA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		4 / 6 LEU A  96
ALA A 100
LEU A   1
THR A 103
 None
 1.08A 3cfqA-3fynA:
undetectable		 3cfqA-3fynA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		5 / 12 LEU A  43
ALA A  39
ALA A  35
PRO A  32
GLU A 154
 None
 1.24A 3cwkA-3fynA:
undetectable		 3cwkA-3fynA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		5 / 12 PHE A  85
ALA A 100
GLY A  93
ALA A  91
ILE A  55
 None
None
ACT  A 202 (-3.7A)
None
None
 0.93A 3lbdA-3fynA:
undetectable		 3lbdA-3fynA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		4 / 8 PHE A  86
VAL A  87
ILE A  55
ALA A   8
 None
ACT  A 202 ( 4.9A)
None
None
 0.80A 4eyzA-3fynA:
undetectable		 4eyzA-3fynA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		4 / 8 PHE A  86
VAL A  87
ILE A  55
ALA A   8
 None
ACT  A 202 ( 4.9A)
None
None
 0.81A 4eyzB-3fynA:
undetectable		 4eyzB-3fynA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3
(uncultured
bacterium) 		4 / 8 VAL A  62
ILE A  52
VAL A 104
THR A 103
 None
 0.66A 4ma7A-3fynA:
undetectable		 4ma7A-3fynA:
17.58