SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		4 / 6 ALA A1990
LEU A2042
ASP A2038
LEU A2035
 None
 0.67A 1mt1D-3fyqA:
undetectable
1mt1E-3fyqA:
undetectable		 1mt1D-3fyqA:
19.80
1mt1E-3fyqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 0.99A 3ln1A-3fyqA:
undetectable		 3ln1A-3fyqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 0.99A 3ln1B-3fyqA:
undetectable		 3ln1B-3fyqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 0.99A 3ln1C-3fyqA:
undetectable		 3ln1C-3fyqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		4 / 8 SER A2111
THR A1984
ALA A2056
ALA A2057
 None
 0.92A 3ns1L-3fyqA:
undetectable		 3ns1L-3fyqA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		3 / 3 SER A2080
GLY A2079
GLN A2086
 None
 0.60A 3v4tH-3fyqA:
undetectable		 3v4tH-3fyqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ILE A2090
VAL A2093
LEU A2137
LEU A2001
ALA A2070
 None
 1.26A 4m11D-3fyqA:
undetectable		 4m11D-3fyqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ASP A2038
VAL A2096
ALA A2099
VAL A1994
GLY A2101
 None
 1.20A 4mm6A-3fyqA:
undetectable		 4mm6A-3fyqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 1.00A 5jw1A-3fyqA:
undetectable		 5jw1A-3fyqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 1.07A 5kirA-3fyqA:
undetectable		 5kirA-3fyqA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		5 / 12 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 1.10A 5kirB-3fyqA:
undetectable		 5kirB-3fyqA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		4 / 8 ALA A1990
VAL A1994
THR A2063
GLY A2101
 None
 1.00A 5v0vA-3fyqA:
4.3		 5v0vA-3fyqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		3 / 3 THR A2140
ALA A2092
LYS A2094
 None
 0.63A 6fgcA-3fyqA:
undetectable		 6fgcA-3fyqA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3fyq CG6831-PA (TALIN)
(Drosophila
melanogaster) 		3 / 3 THR A2140
ALA A2092
LYS A2094
 None
 0.58A 6fgdA-3fyqA:
undetectable		 6fgdA-3fyqA:
19.24