SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 GLY A 262
LEU A  88
GLN A 123
THR A 267
GLY A 266
 None
 1.49A 1kvlA-3fysA:
undetectable		 1kvlA-3fysA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 11 ILE A  66
GLY A  94
SER A  93
LEU A  88
HIS A  87
 None
None
PLM  A 501 (-2.8A)
None
None
 1.41A 1kyvA-3fysA:
undetectable
1kyvB-3fysA:
undetectable		 1kyvA-3fysA:
21.15
1kyvB-3fysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 11 ILE A  66
LEU A  69
GLY A  94
LEU A  88
HIS A  87
 None
 1.35A 1kyvA-3fysA:
undetectable
1kyvB-3fysA:
undetectable		 1kyvA-3fysA:
21.15
1kyvB-3fysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		4 / 6 ALA A 122
LEU A 121
ILE A 232
SER A 119
 None
None
PLM  A 501 (-4.0A)
PLM  A 501 ( 4.7A)
 0.94A 1sbrA-3fysA:
undetectable
1sbrB-3fysA:
undetectable		 1sbrA-3fysA:
20.39
1sbrB-3fysA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 ILE A 232
LEU A 121
PHE A 125
ALA A 229
ALA A 230
 PLM  A 501 (-4.0A)
None
None
None
None
 0.96A 2oc8A-3fysA:
undetectable		 2oc8A-3fysA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 TYR A  49
GLY A 270
GLY A 266
LEU A 274
GLY A 272
 None
 0.77A 3axzA-3fysA:
undetectable		 3axzA-3fysA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 9 ILE A 203
ILE A 189
MET A 160
ILE A 213
ILE A 210
 None
None
BR  A 702 (-4.8A)
None
None
 1.23A 3p4wB-3fysA:
undetectable		 3p4wB-3fysA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 ILE A 203
ILE A 189
MET A 160
ILE A 213
ILE A 210
 None
None
BR  A 702 (-4.8A)
None
None
 1.23A 3p4wD-3fysA:
undetectable		 3p4wD-3fysA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 ILE A 203
ILE A 189
MET A 160
ILE A 213
ILE A 210
 None
None
BR  A 702 (-4.8A)
None
None
 1.23A 3p4wE-3fysA:
undetectable		 3p4wE-3fysA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 VAL A 161
ALA A 273
GLY A 272
ALA A 263
HIS A 268
 None
None
None
None
PLM  A 501 (-3.8A)
 1.00A 3qxyA-3fysA:
undetectable		 3qxyA-3fysA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 GLN A 123
LEU A 121
ILE A 232
LEU A 269
CYH A 120
 None
None
PLM  A 501 (-4.0A)
PLM  A 501 ( 4.6A)
PLM  A 501 ( 3.9A)
 1.46A 4k38A-3fysA:
undetectable
4k38D-3fysA:
undetectable		 4k38A-3fysA:
22.14
4k38D-3fysA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 TYR A 260
CYH A 120
ALA A 122
GLN A 123
GLY A 262
 None
PLM  A 501 ( 3.9A)
None
None
None
 1.43A 4lb9A-3fysA:
0.0		 4lb9A-3fysA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		6 / 8 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
ALA A 229
 None
 1.35A 4m48A-3fysA:
undetectable		 4m48A-3fysA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.35A 4mm4A-3fysA:
undetectable		 4mm4A-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 9 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.04A 4mm5A-3fysA:
undetectable		 4mm5A-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 11 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.28A 4mm9A-3fysA:
undetectable		 4mm9A-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 11 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 0.98A 4mmaA-3fysA:
undetectable		 4mmaA-3fysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 9 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.05A 4mmbA-3fysA:
undetectable		 4mmbA-3fysA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.35A 4mmcA-3fysA:
undetectable		 4mmcA-3fysA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 PRO A 226
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 0.99A 4mmdB-3fysA:
undetectable		 4mmdB-3fysA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 9 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.37A 4mmfB-3fysA:
undetectable		 4mmfB-3fysA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		3 / 3 PRO A 141
VAL A   5
HIS A  24
 None
 0.82A 4pevC-3fysA:
2.6		 4pevC-3fysA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.08A 4xp1A-3fysA:
undetectable		 4xp1A-3fysA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
 None
 1.34A 4xpbA-3fysA:
undetectable		 4xpbA-3fysA:
21.46