SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 VAL A  37
VAL A  41
TRP A  38
 None
 0.99A 1av2A-3fz0A:
undetectable
1av2B-3fz0A:
undetectable		 1av2A-3fz0A:
7.69
1av2B-3fz0A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 ALA A  23
VAL A 129
ILE A  18
THR A  10
ILE A   8
 None
 0.86A 1c6yA-3fz0A:
undetectable		 1c6yA-3fz0A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 ALA A  19
ILE A  18
CYH A  12
GLY A  13
 None
 0.81A 1sv9A-3fz0A:
undetectable		 1sv9A-3fz0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 VAL A  37
VAL A  41
TRP A  38
 None
 0.72A 1w5uA-3fz0A:
undetectable
1w5uB-3fz0A:
undetectable		 1w5uA-3fz0A:
7.69
1w5uB-3fz0A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ARG A 311
GLU A 309
ALA A 176
ALA A 175
 None
 1.07A 2ejfA-3fz0A:
undetectable		 2ejfA-3fz0A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 VAL A  41
TRP A  38
VAL A  37
 None
 0.73A 2izqC-3fz0A:
undetectable
2izqD-3fz0A:
undetectable		 2izqC-3fz0A:
7.69
2izqD-3fz0A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A  81
GLY A  14
GLY A  87
LEU A 250
LEU A 131
 None
 1.05A 2nxeB-3fz0A:
4.0		 2nxeB-3fz0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 7 ALA A 130
GLY A 132
ASP A   9
VAL A  37
LEU A 128
 None
CA  A 400 ( 4.4A)
None
None
None
 1.26A 2uyqA-3fz0A:
2.6		 2uyqA-3fz0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 134
ALA A 138
ILE A 159
ALA A 130
ASP A 183
 None
 1.08A 3axtA-3fz0A:
4.2		 3axtA-3fz0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 TYR A  57
ALA A  19
MET A  24
ASP A   9
LEU A 131
 None
 1.42A 3ou6D-3fz0A:
2.5		 3ou6D-3fz0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 132
ASN A 163
ALA A 107
ALA A 108
TRP A  38
 CA  A 400 ( 4.4A)
None
None
None
None
 1.00A 3p2kA-3fz0A:
2.9		 3p2kA-3fz0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 LEU A 151
ILE A 159
LEU A 141
LEU A 112
ILE A 114
 None
 1.17A 4dm8A-3fz0A:
undetectable		 4dm8A-3fz0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ARG A 330
LYS A 327
LYS A 328
 None
 1.44A 4k50A-3fz0A:
undetectable		 4k50A-3fz0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ARG A 330
LYS A 327
LYS A 328
 None
 1.40A 4k50I-3fz0A:
undetectable		 4k50I-3fz0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 LEU A  22
LEU A 349
LEU A 346
THR A 214
VAL A 340
 None
 1.38A 4mk4A-3fz0A:
2.9		 4mk4A-3fz0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 PHE A 178
LEU A 134
VAL A  37
GLY A  14
ASP A  16
 BTB  A 401 (-3.9A)
None
None
None
CA  A 400 (-2.3A)
 1.44A 4mubA-3fz0A:
undetectable		 4mubA-3fz0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ALA A  23
VAL A 129
ILE A  18
THR A  10
ILE A   8
 None
 1.01A 4njuB-3fz0A:
undetectable		 4njuB-3fz0A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ALA A  23
VAL A 129
ILE A  18
THR A  10
ILE A   8
 None
 1.02A 4njuD-3fz0A:
undetectable		 4njuD-3fz0A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A  23
VAL A 129
ILE A  18
THR A  10
ILE A   8
 None
 0.92A 4njvD-3fz0A:
undetectable		 4njvD-3fz0A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 191
TRP A 196
VAL A 189
GLY A 187
ALA A 186
 None
 1.08A 4rrxA-3fz0A:
undetectable		 4rrxA-3fz0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 191
TRP A 196
VAL A 189
GLY A 187
ALA A 186
 None
 1.08A 4rrxB-3fz0A:
undetectable		 4rrxB-3fz0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 VAL A 200
ILE A 159
LEU A 128
PHE A 148
GLY A 187
 None
 1.01A 5mxbA-3fz0A:
undetectable		 5mxbA-3fz0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU A 349
ALA A 348
PHE A 345
VAL A 278
ILE A  18
 None
 1.15A 5om2A-3fz0A:
undetectable
5om2B-3fz0A:
undetectable		 5om2A-3fz0A:
12.32
5om2B-3fz0A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 VAL A  31
ILE A  34
ILE A  50
LEU A  53
THR A  25
 None
 0.85A 5uvmB-3fz0A:
undetectable		 5uvmB-3fz0A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 161
LEU A 131
THR A  35
ALA A 281
VAL A 282
 None
 0.87A 5x66F-3fz0A:
undetectable		 5x66F-3fz0A:
20.81