SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.26A 1hvyA-3fz4A:
undetectable		 1hvyA-3fz4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.26A 1hvyC-3fz4A:
undetectable		 1hvyC-3fz4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.15A 1ju6A-3fz4A:
undetectable		 1ju6A-3fz4A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.14A 1ju6D-3fz4A:
undetectable		 1ju6D-3fz4A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		3 / 3 TRP A  45
THR A   3
TYR A   5
 None
 1.27A 2a3bA-3fz4A:
undetectable		 2a3bA-3fz4A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 LEU A  84
ASN A  83
LEU A  85
ALA A  82
LEU A  73
 None
 1.33A 2aa6A-3fz4A:
undetectable		 2aa6A-3fz4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 ILE A  92
LEU A  51
LEU A  96
ILE A 103
LEU A  46
 None
None
None
FMT  A 205 (-4.6A)
None
 1.07A 3a50C-3fz4A:
undetectable		 3a50C-3fz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 ILE A  92
LEU A  51
LEU A  96
ILE A 103
LEU A  46
 None
None
None
FMT  A 205 (-4.6A)
None
 1.04A 3a50E-3fz4A:
undetectable		 3a50E-3fz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 ILE A  92
LEU A  51
LEU A  96
ILE A 103
LEU A  46
 None
None
None
FMT  A 205 (-4.6A)
None
 1.01A 3vrmA-3fz4A:
undetectable		 3vrmA-3fz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		4 / 8 LEU A  97
ASP A  26
TYR A  27
PHE A   4
 NA  A 201 (-4.6A)
None
None
None
 1.00A 4drjB-3fz4A:
undetectable		 4drjB-3fz4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.14A 5x66A-3fz4A:
undetectable
5x66B-3fz4A:
undetectable		 5x66A-3fz4A:
17.81
5x66B-3fz4A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.16A 5x66F-3fz4A:
undetectable		 5x66F-3fz4A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.23A 6r2eA-3fz4A:
undetectable		 6r2eA-3fz4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 10 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.28A 6r2eC-3fz4A:
undetectable		 6r2eC-3fz4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 10 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.23A 6r2eD-3fz4A:
undetectable		 6r2eD-3fz4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.21A 6r2eF-3fz4A:
undetectable		 6r2eF-3fz4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.21A 6r2eG-3fz4A:
undetectable		 6r2eG-3fz4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3fz4 PUTATIVE ARSENATE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 PHE A  56
ILE A  42
ASP A  88
LEU A  91
GLY A  89
 None
 1.25A 6r2eH-3fz4A:
undetectable		 6r2eH-3fz4A:
16.36