SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 7 PHE A   6
PRO A 172
ALA A  19
PHE A 113
 None
 1.15A 1lqtA-3fz5A:
undetectable		 1lqtA-3fz5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 7 PHE A   6
PRO A 172
ALA A  19
PHE A 113
 None
 1.13A 1lquA-3fz5A:
undetectable		 1lquA-3fz5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		5 / 11 ILE A 168
ALA A 163
GLY A 160
GLU A 161
GLU A   5
 None
 1.48A 1n6cA-3fz5A:
undetectable		 1n6cA-3fz5A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 5 ALA A 109
TRP A  35
LEU A  34
ALA A 105
 None
 1.23A 2jstA-3fz5A:
undetectable
2jstB-3fz5A:
undetectable		 2jstA-3fz5A:
13.07
2jstB-3fz5A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 8 ARG A  36
TYR A  95
ASP A 103
GLU A  23
 None
 1.27A 3dh0A-3fz5A:
undetectable		 3dh0A-3fz5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		5 / 11 ILE A 147
ALA A 151
LEU A 152
THR A 155
VAL A 156
 None
 1.01A 4g1bB-3fz5A:
undetectable		 4g1bB-3fz5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 6 ASP A 114
LEU A  75
PHE A  16
ILE A  22
 CA  A 202 (-2.4A)
None
None
None
 1.11A 4y4dA-3fz5A:
undetectable		 4y4dA-3fz5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 4 LEU A 175
ARG A  31
ILE A   4
ILE A 194
 None
 0.99A 5dzk2-3fz5A:
undetectable
5dzkM-3fz5A:
undetectable
5dzkN-3fz5A:
undetectable		 5dzk2-3fz5A:
1.36
5dzkM-3fz5A:
22.02
5dzkN-3fz5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 5 LEU A 175
ARG A  31
ILE A   4
ILE A 194
 None
 1.02A 5dzk4-3fz5A:
undetectable
5dzkg-3fz5A:
undetectable
5dzkm-3fz5A:
undetectable
5dzkn-3fz5A:
undetectable		 5dzk4-3fz5A:
1.36
5dzkg-3fz5A:
23.63
5dzkm-3fz5A:
22.02
5dzkn-3fz5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Rhodobacter
sphaeroides) 		4 / 4 ILE A   4
ILE A 194
ARG A  31
LEU A 175
 None
 1.14A 5dzkh-3fz5A:
undetectable
5dzkn-3fz5A:
undetectable
5dzkv-3fz5A:
undetectable		 5dzkh-3fz5A:
22.02
5dzkn-3fz5A:
22.02
5dzkv-3fz5A:
1.36