SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 11 GLU A 142
LEU A 146
PHE A 145
ILE A  82
LEU A  79
 SAM  A 300 ( 4.6A)
None
None
None
None
 1.18A 1jomA-3fzgA:
undetectable		 1jomA-3fzgA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 GLU A 129
ASN A 126
TRP A 125
 None
 1.03A 1r15C-3fzgA:
undetectable		 1r15C-3fzgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 GLU A 129
ASN A 126
TRP A 125
 None
 1.01A 1r15D-3fzgA:
undetectable		 1r15D-3fzgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 GLU A 129
ASN A 126
TRP A 125
 None
 1.01A 1r15E-3fzgA:
undetectable		 1r15E-3fzgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 GLU A 129
ASN A 126
TRP A 125
 None
 1.01A 1r15F-3fzgA:
undetectable		 1r15F-3fzgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 6 TYR A 133
ASP A 112
ASN A 118
GLU A 127
 None
 1.31A 1rjdA-3fzgA:
8.4		 1rjdA-3fzgA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 6 TYR A 133
ASP A 112
ASN A 118
GLU A 127
 None
 1.31A 1rjdB-3fzgA:
8.7		 1rjdB-3fzgA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 11 PHE A 177
ILE A 157
TYR A 159
LEU A 146
ILE A 150
 None
 1.35A 1yatA-3fzgA:
undetectable		 1yatA-3fzgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		6 / 12 ASP A 112
GLY A 114
GLY A 116
ILE A 138
ASP A 139
LEU A 185
 None
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-3.7A)
None
None
 0.78A 2nxeA-3fzgA:
10.6		 2nxeA-3fzgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 ASP A 112
GLY A 114
GLY A 116
ASP A 139
LEU A 185
 None
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
None
None
 0.78A 2nxeB-3fzgA:
11.0		 2nxeB-3fzgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 ASP A 112
GLY A 114
GLY A 116
ILE A 138
ASP A 139
 None
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-3.7A)
None
 0.63A 2nxeB-3fzgA:
11.0		 2nxeB-3fzgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		6 / 12 ASP A 112
GLY A 114
ASP A 137
ILE A 138
ASP A 139
LEU A 185
 None
SAM  A 300 (-3.5A)
SAM  A 300 (-2.9A)
SAM  A 300 (-3.7A)
None
None
 0.84A 3cjtC-3fzgA:
10.9		 3cjtC-3fzgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 GLY A 114
GLY A 116
ILE A 138
ASP A 139
LEU A 185
 SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-3.7A)
None
None
 0.87A 3cjtO-3fzgA:
11.2		 3cjtO-3fzgA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		12 / 12 HIS A  83
SER A  85
THR A  86
PHE A 113
GLY A 114
GLY A 116
ILE A 138
LEU A 179
LYS A 180
MET A 181
VAL A 184
GLN A 188
 SAM  A 300 (-4.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.7A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-3.7A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.0A)
None
SAM  A 300 (-3.3A)
 0.00A 3fzgA-3fzgA:
37.6		 3fzgA-3fzgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		6 / 12 HIS A  83
SER A  85
THR A  86
ILE A 138
LEU A 179
LYS A 180
 SAM  A 300 (-4.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.7A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.7A)
 0.56A 3lcvB-3fzgA:
19.9		 3lcvB-3fzgA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 HIS A  83
SER A  85
THR A  86
LEU A 185
LEU A 179
 SAM  A 300 (-4.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.7A)
None
SAM  A 300 (-4.0A)
 0.95A 3lcvB-3fzgA:
19.9		 3lcvB-3fzgA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 ARG A  89
ASP A 137
GLN A 188
 SAM  A 300 (-2.9A)
SAM  A 300 (-2.9A)
SAM  A 300 (-3.3A)
 0.52A 3lcvB-3fzgA:
19.9		 3lcvB-3fzgA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 6 LEU A 179
GLU A 247
PRO A 209
ARG A  89
 SAM  A 300 (-4.0A)
None
None
SAM  A 300 (-2.9A)
 1.32A 3ltwA-3fzgA:
undetectable		 3ltwA-3fzgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 8 PHE A  96
ILE A 110
ILE A 157
PHE A 101
 None
 0.87A 3uqbA-3fzgA:
undetectable		 3uqbA-3fzgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 11 LEU A 120
LEU A 146
ILE A 150
LEU A  74
ILE A  82
 None
 1.14A 4dm8A-3fzgA:
undetectable		 4dm8A-3fzgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 PHE A 195
TYR A 136
TYR A 169
 None
SAM  A 300 (-4.7A)
None
 0.96A 4ffwA-3fzgA:
undetectable		 4ffwA-3fzgA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 5 PRO A 119
ASP A 112
ILE A 143
VAL A 168
 None
 1.38A 4hytA-3fzgA:
2.9		 4hytA-3fzgA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 PHE A  96
SER A 207
LEU A 178
GLU A 142
ASP A 137
 None
None
None
SAM  A 300 ( 4.6A)
SAM  A 300 (-2.9A)
 1.29A 4qb9E-3fzgA:
undetectable		 4qb9E-3fzgA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 THR A 155
HIS A  83
LEU A 146
 None
SAM  A 300 (-4.4A)
None
 0.61A 5axdA-3fzgA:
4.6		 5axdA-3fzgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 THR A 155
HIS A  83
LEU A 146
 None
SAM  A 300 (-4.4A)
None
 0.63A 5axdC-3fzgA:
4.5		 5axdC-3fzgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 GLY A 114
GLY A 116
ASP A 137
GLU A 165
LEU A 179
 SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-2.9A)
None
SAM  A 300 (-4.0A)
 1.07A 5bw4A-3fzgA:
3.8		 5bw4A-3fzgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 GLU A 142
HIS A  83
ASP A 112
 SAM  A 300 ( 4.6A)
SAM  A 300 (-4.4A)
None
 0.80A 5c0oG-3fzgA:
10.3		 5c0oG-3fzgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 GLY A 114
GLY A 116
ASP A 137
ILE A 138
LEU A 185
 SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-2.9A)
SAM  A 300 (-3.7A)
None
 0.63A 5wy0A-3fzgA:
11.0		 5wy0A-3fzgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3fzg 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 GLY A 114
ASP A 137
ILE A 138
ASP A 139
LEU A 185
 SAM  A 300 (-3.5A)
SAM  A 300 (-2.9A)
SAM  A 300 (-3.7A)
None
None
 0.57A 6bq4A-3fzgA:
8.4		 6bq4A-3fzgA:
18.97