SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LYS A 457
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.89A 1m17A-3fzpA:
31.8		 1m17A-3fzpA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 9 LEU A 431
VAL A 439
ALA A 455
MET A 502
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 0.80A 1xbbA-3fzpA:
33.4		 1xbbA-3fzpA:
38.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		4 / 4 LEU A 654
PRO A 625
ILE A 618
LEU A 619
 None
 0.99A 1ya4B-3fzpA:
undetectable		 1ya4B-3fzpA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		4 / 6 LEU A 431
VAL A 487
ILE A 500
ARG A 548
 AGS  A 999 ( 4.4A)
None
None
None
 0.96A 2hyyA-3fzpA:
31.8		 2hyyA-3fzpA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLU A 474
GLY A 508
LEU A 556
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 1.32A 2itzA-3fzpA:
31.6		 2itzA-3fzpA:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 9 LEU A 431
VAL A 439
ALA A 455
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
 0.76A 2xp2A-3fzpA:
13.9		 2xp2A-3fzpA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 VAL A 439
ALA A 455
LEU A 504
GLY A 508
GLU A 509
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.55A 2y7jA-3fzpA:
23.8		 2y7jA-3fzpA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 10 LEU A 431
ALA A 455
LYS A 457
VAL A 487
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.99A 3aoxA-3fzpA:
30.9		 3aoxA-3fzpA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 VAL A 439
ALA A 455
LEU A 489
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.62A 3bbtB-3fzpA:
30.3		 3bbtB-3fzpA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
GLY A 432
GLU A 441
ALA A 455
LYS A 457
VAL A 487
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
None
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-4.5A)
 0.65A 3c7qA-3fzpA:
30.9		 3c7qA-3fzpA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 9 LEU A 431
VAL A 439
VAL A 487
ILE A 500
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
None
None
AGS  A 999 (-4.5A)
 0.69A 3cs9B-3fzpA:
31.6		 3cs9B-3fzpA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
VAL A 439
ALA A 455
GLU A 474
VAL A 487
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
 0.76A 3gvuA-3fzpA:
31.0		 3gvuA-3fzpA:
38.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
VAL A 487
ILE A 500
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
None
AGS  A 999 (-4.5A)
 0.68A 3sxrA-3fzpA:
30.8		 3sxrA-3fzpA:
37.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		4 / 6 LEU A 531
PHE A 611
ALA A 612
LEU A 654
 None
 0.90A 3t3zB-3fzpA:
undetectable		 3t3zB-3fzpA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LYS A 457
GLU A 474
ILE A 500
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 1.00A 3ue4A-3fzpA:
33.1		 3ue4A-3fzpA:
41.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
MET A 502
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.74A 3ug2A-3fzpA:
31.9		 3ug2A-3fzpA:
35.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 12 ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
 0.52A 3zbfA-3fzpA:
25.8		 3zbfA-3fzpA:
39.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 9 LEU A 431
ILE A 477
MET A 478
LEU A 481
ILE A 486
 AGS  A 999 ( 4.4A)
None
None
None
None
 1.14A 3zosB-3fzpA:
30.3		 3zosB-3fzpA:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 11 LEU A 431
ALA A 455
LYS A 457
VAL A 487
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-4.5A)
 0.80A 4agdA-3fzpA:
30.5		 4agdA-3fzpA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 11 LEU A 431
GLY A 432
GLY A 434
VAL A 439
ALA A 455
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
AGS  A 999 (-3.0A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
 0.85A 4ckiA-3fzpA:
30.8		 4ckiA-3fzpA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.87A 4hjoA-3fzpA:
31.0		 4hjoA-3fzpA:
34.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 GLY A 432
VAL A 439
ALA A 455
LYS A 457
LEU A 489
GLU A 509
LEU A 556
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.80A 4ifgA-3fzpA:
21.3		 4ifgA-3fzpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 GLY A 432
VAL A 439
LYS A 457
LEU A 489
GLY A 508
GLU A 509
LEU A 556
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.73A 4ifgA-3fzpA:
21.3		 4ifgA-3fzpA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
GLY A 434
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.0A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.64A 4mkcA-3fzpA:
32.1		 4mkcA-3fzpA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 11 LEU A 431
GLY A 432
VAL A 439
ALA A 455
LYS A 457
ASN A 554
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
 0.88A 4o0sA-3fzpA:
24.9		 4o0sA-3fzpA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		4 / 6 VAL A 439
ALA A 455
LYS A 457
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
 0.66A 4o0uA-3fzpA:
8.7		 4o0uA-3fzpA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LYS A 457
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.88A 4wkqA-3fzpA:
31.3		 4wkqA-3fzpA:
35.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 9 LEU A 431
VAL A 439
ALA A 455
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
 0.73A 5aaaA-3fzpA:
32.1		 5aaaA-3fzpA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 10 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
None
 0.97A 5aabA-3fzpA:
31.7		 5aabA-3fzpA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 10 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
None
 1.07A 5aacA-3fzpA:
31.5		 5aacA-3fzpA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
 0.84A 5h2uA-3fzpA:
29.0		 5h2uA-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
 0.86A 5h2uA-3fzpA:
29.0		 5h2uA-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
VAL A 439
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.08A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
AGS  A 999 ( 3.9A)
 1.10A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 VAL A 439
ALA A 455
ILE A 500
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.08A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 ALA A 455
ILE A 500
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.09A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
ALA A 455
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.07A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
ALA A 455
LYS A 457
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.05A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 ALA A 455
ILE A 500
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.05A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.06A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LEU A 504
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.01A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 GLY A 432
VAL A 439
ALA A 455
LYS A 457
GLU A 474
GLY A 508
GLU A 509
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-3.8A)
 0.76A 5mafA-3fzpA:
23.7		 5mafA-3fzpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 10 LEU A 431
VAL A 439
ALA A 455
VAL A 487
MET A 502
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 0.77A 5n3hA-3fzpA:
22.0		 5n3hA-3fzpA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.81A 5y7zA-3fzpA:
22.3		 5y7zA-3fzpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.81A 5y7zA-3fzpA:
22.3		 5y7zA-3fzpA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 GLY A 432
VAL A 439
ALA A 455
LYS A 457
LEU A 556
ASP A 567
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.85A 5yu9B-3fzpA:
25.1		 5yu9B-3fzpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
ASP A 567
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.94A 5yu9D-3fzpA:
29.9		 5yu9D-3fzpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		3 / 3 MET A 610
ASP A 549
ARG A 600
 None
 1.21A 5z6kA-3fzpA:
undetectable		 5z6kA-3fzpA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 9 ALA A 551
MET A 610
ASP A 549
LYS A 585
ILE A 597
 None
 1.48A 5z6lA-3fzpA:
undetectable		 5z6lA-3fzpA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		3 / 3 GLN A 624
TRP A 591
VAL A 613
 None
 1.07A 6auuA-3fzpA:
undetectable		 6auuA-3fzpA:
24.59