SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		5 / 9 SER A 234
LEU A   7
ILE A 263
ILE A  51
GLY A  45
 None
None
None
None
PO4  A 274 (-3.7A)
 1.17A 3cv9A-3fzqA:
undetectable		 3cv9A-3fzqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		5 / 12 ASN A  80
VAL A 110
ILE A 104
ILE A 156
SER A  82
 None
 1.23A 3kpbA-3fzqA:
undetectable		 3kpbA-3fzqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 7 ILE A 273
LEU A 267
LEU A   9
VAL A  55
 None
 1.00A 3r9vA-3fzqA:
undetectable
3r9vB-3fzqA:
undetectable		 3r9vA-3fzqA:
23.05
3r9vB-3fzqA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 5 SER A 243
ASP A  17
ASP A  54
ILE A  22
 None
 1.27A 3uj7B-3fzqA:
undetectable		 3uj7B-3fzqA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 6 GLU A  76
GLY A  75
LEU A  78
TYR A  73
 None
 1.04A 3w9tB-3fzqA:
undetectable		 3w9tB-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		3 / 3 ASP A  17
GLY A 128
TYR A  20
 None
 0.75A 3w9tC-3fzqA:
undetectable		 3w9tC-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 6 GLU A  76
GLY A  75
LEU A  78
TYR A  73
 None
 1.03A 3w9tE-3fzqA:
undetectable		 3w9tE-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 6 GLU A  76
GLY A  75
LEU A  78
TYR A  73
 None
 1.02A 3w9tF-3fzqA:
undetectable		 3w9tF-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		3 / 3 ASP A  17
GLY A 128
TYR A  20
 None
 0.74A 3w9tG-3fzqA:
undetectable		 3w9tG-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		5 / 12 PHE A 221
LEU A  58
VAL A  40
ILE A  30
LEU A 267
 None
 1.47A 4k38B-3fzqA:
undetectable		 4k38B-3fzqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		5 / 12 PHE A 221
LEU A  58
VAL A  40
ILE A  30
LEU A 267
 None
 1.42A 4k39A-3fzqA:
undetectable		 4k39A-3fzqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		5 / 12 ASP A 185
TYR A 190
SER A 188
ALA A 116
ALA A 101
 None
 1.18A 5cxvA-3fzqA:
undetectable		 5cxvA-3fzqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 8 ASP A  12
ILE A 138
ARG A  46
TYR A 190
 PO4  A 274 (-3.7A)
None
None
None
 1.05A 6hisA-3fzqA:
undetectable
6hisB-3fzqA:
undetectable		 6hisA-3fzqA:
16.39
6hisB-3fzqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 8 ASP A  12
ILE A 138
ARG A  46
TYR A 190
 PO4  A 274 (-3.7A)
None
None
None
 1.04A 6hisB-3fzqA:
undetectable
6hisC-3fzqA:
undetectable		 6hisB-3fzqA:
16.39
6hisC-3fzqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 8 ASP A  12
ILE A 138
ARG A  46
TYR A 190
 PO4  A 274 (-3.7A)
None
None
None
 1.03A 6hisC-3fzqA:
undetectable
6hisD-3fzqA:
undetectable		 6hisC-3fzqA:
16.39
6hisD-3fzqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 8 ASP A  12
ILE A 138
ARG A  46
TYR A 190
 PO4  A 274 (-3.7A)
None
None
None
 1.06A 6hisD-3fzqA:
undetectable
6hisE-3fzqA:
undetectable		 6hisD-3fzqA:
16.39
6hisE-3fzqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3fzq PUTATIVE HYDROLASE
(Clostridioides
difficile) 		4 / 8 TYR A 190
ASP A  12
ILE A 138
ARG A  46
 None
PO4  A 274 (-3.7A)
None
None
 1.04A 6hisA-3fzqA:
undetectable
6hisE-3fzqA:
undetectable		 6hisA-3fzqA:
16.39
6hisE-3fzqA:
16.39